1BMO


Conserved Protein Domain Family
FSL_SPARC
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cd01328: FSL_SPARC 
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Follistatin-like SPARC (secreted protein, acidic, and rich in cysteines) domain; SPARC/BM-40/osteonectin is a multifunctional glycoprotein which modulates cellular interaction with the extracellular matrix by its binding to structural matrix proteins such as collagen and vitronectin. The protein it composed of an N-terminal acidic region, a follistatin (FS) domain and an EF-hand calcium binding domain. The FS domain consists of an N-terminal beta hairpin (FOLN/EGF-like domain) and a small hydrophobic core of alpha/beta structure (Kazal domain) and has five disulfide bonds and a conserved N-glycosylation site. The FSL_SPARC domain is a member of the superfamily of kazal-like proteinase inhibitors and follistatin-like proteins.
Links
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Statistics
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PSSM-Id: 238649
Aligned: 10 rows
Threshold Bit Score: 123.357
Created: 16-Jun-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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N-glycosylation
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:N-glycosylation site [posttranslational modification site]
Evidence:
  • Structure:1BM0; BM-40 glycosylated at conserved Asn residue.
  • Comment:Two N-acetylglucosamine sugars contact the linker segment connecting the FS and EC domains and may contribute to stabilization between domains.
  • Citation:PMID 9233787
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                   #                                 
1BMO_A      1 PCQNHHCKHGKVCELDENnTPMCVCQDptsCPAPIGef-eKVCSNDNKTFDSSCHFFATKCTLEGTKKGh------KLHL 73  human
P34714     52 PCEDHQCGWGKECVVGKKgEPTCECISk--CPELDGdpmdKVCANNNQTFTSLCDLYRERCLCKRKSKEcskafnaKVHL 129 nematode
P36377     66 PCQNHHCKHGKVCEVDDNnSPMCVCQDpssCPAHSGvf-eKVCGTDNKTYDSSCHFFATKCTLEGTKKGh------KLHL 138 chicken
P36378     68 PCLNHHCKHGKVCEVDESnTPLCVCQDpstCPTSVGef-eKICGTDNKTYDSSCHFFATKCTLEGTKKGh------KLHL 140 African clawed frog
AAC99813   68 PCLNHHCKKGKVCEVDEEnTPMCVCQDpttCPGAVGef-eHVCATDNTTYDSSCHFFAQKCSLEGTKKGh------KLHL 140 rainbow trout
BAB20042   70 PCAKKRCGAGKECKISDSgEAECRCVEs--CLPEVDdr-rKVCTNHNETFNSDCELYRMRCLCTTGSQEclgpkysHAHI 146 Artemia franciscana
AAL49360   84 LCETMSCGAGRICQMHDE-KPKCVCIPe--CPEEVDtr-rLVCTNTNETWPSDCSVYQQRCWCDSGEPGctnpdnaHMHI 159 fruit fly
AAT01212  133 PCDLFPCKPGKECYLTKTnKPKCRCIVe--CDSSETd--fRVCGTDNNTYTSECELWRTKCIMKQNKAKgv----qHLRL 204 Ciona intestinalis
XP_392466  83 PCMDKHCDAGRVCKAVDDeTAECVCIEi--CDKEIDpr-rKVCTNHNETFGSDCEVYQARCFCDTNDPRcrgtkyqHVHV 159 honey bee
AAV88596   96 PCAEKHCGAGQVCEVNEQgEGHCVCIPd--CPVEVDpr-rKVCSNHNETWGSDCEVYQMRCWCKHGMDGcrgdeysHVHI 172 desert locust

Feature 1              
1BMO_A     74 DYIGPCKYI 82  human
P34714    130 EYLGECKKL 138 nematode
P36377    139 DYIGPCKFI 147 chicken
P36378    141 DYIGPCKYI 149 African clawed frog
AAC99813  141 DYIGPCKFI 149 rainbow trout
BAB20042  147 EYYGECRDM 155 Artemia franciscana
AAL49360  160 DYYGACHEP 168 fruit fly
AAT01212  205 DYYGDCKEI 213 Ciona intestinalis
XP_392466 160 VYYGECRQM 168 honey bee
AAV88596  173 EYYGECRDM 181 desert locust

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