Conserved Protein Domain Family
ADGF

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cd01321: ADGF 
Adenosine deaminase-related growth factors (ADGF), a novel family of secreted growth-factors with sequence similarty to adenosine deaminase.
Statistics
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PSSM-Id: 238646
Aligned: 15 rows
Threshold Bit Score: 441.711
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
active site
Feature 1:active site [active site]
Evidence:
  • Comment:active site is based on homology to other members of the adenosine deaminase family

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                      # #                                            
AAD52851   77 PAMH-FFKAKHIIEn--SMVFKFLKKMPKGgALHLHALGSVSPEWIIKNITYlpglkkcinranapvltfrpnaephmck 153 Glossina morsitans...
CAD37012   97 PGMM-FTLAKETMEa--TKLWRIVRKMPKGaLLHSHCDAMVDFDFLLGVVLEtegmgiatpergglgteerrreaevvvk 173 Neurospora crassa
EAA63979   74 PGMS-FTLSRDRMQk--TALWKIVSAMPKGcLLHAHMEAMIDIDWMIEQAIElpgyyisspvplcprtgsagkwsepfqf 150 Aspergillus nidula...
P15287     87 PAAS-FYRSKDFIDt--TFAYKIIQDMPKGgALHLHDLAIASLDWVVKNATYrdnvymcmdkdndvnlrvlqlippdpfc 163 California sea hare
EAA04809   74 AGMH-FFDAKPFIEn--STVFEALKLMPKGaILHLHNSAAVSSSWVIKNLTYraeaklcnvddryyftvrplnfcpenqt 150 Anopheles gambiae ...
Q9NZK5     82 PSMH-FFQAKHLIEr--SQVFNILRMMPKGaALHLHDIGIVTMDWLVRNVTYrphchicftprgimqfrfahptprpsek 158 human
P58781     75 PSMH-FFKAKRLIDq--SPVFNLIQKMPKGaALHVHDFAMVSVDWLVKNVTYrencyvcftdkqtvqfifssgppasssh 151 zebrafish
EAA62652   82 PHPS-RMSNRDRVRvesSDLWSIVRRLPKGsLLHGHLPAMVDMDFLIDQAFAtpgihvsaprplltqgdfqdapfafryc 160 Aspergillus nidula...
BAB18576  132 SQPPpFLKHLNIID---TNLYAALKSMPKGgLLHVHDSGMLRMEILIDLIYRdnlwvcvnleqdfedfrfsryfphippa 208 fruit fly
AAO52254  113 SGVN-FFIEKQIIEn-eSTIFKIIQNMPKGsALHVHQDSSATYDYLISVGSYlpncyiyltydvndanngtfhfydsqpt 190 Dictyostelium disc...
Feature 1                                                                                     
AAD52851  154 fdytdvnde-------------------------------rksenaeeydkklaaafnlftptpekdyptintvwgRFVQ 202 Glossina morsitans...
CAD37012  174 fvgelerkvdaksiwagdeegggggyepgtfinlveaadafpdggrkgflqwlksrcilsqtdaieqrhgsaeiwrKFIR 253 Neurospora crassa
EAA63979  151 syrprlgsganarngsepeisiwqagytpgrlvpvaaaakmypggveafkawavsrmtineeealehhhgiddvwdKFRS 230 Aspergillus nidula...
P15287    164 vwklvater-------------------------------ansgdveafddwlkknisylstdpvtqyatvdsvwvRFNK 212 California sea hare
EAA04809  151 rpinqlrk--------------------------------erkddidtfdiwlesfismklkptrigyastdelwlDFES 198 Anopheles gambiae ...
Q9NZK5    159 cskwilledy-----------------------------rkrvqnvtefddsllrnftlvtqhpeviytnqnvvwsKFET 209 human
P58781    152 csswtllrsl-----------------------------rekikntteldnsfirnltlftedpdraypnqdtvweRFEQ 202 zebrafish
EAA62652  161 srsdgghtdkr--------------------------slwadsyepstmidlqsaaasfpdkksgfrqwlksrctlASDQ 214 Aspergillus nidula...
BAB18576  209 edyqcnwml-------------------------------msnffqlesrlefenrlrkiltvrpegykssselvrHLRR 257 fruit fly
AAO52254  191 dsnwklls---------------------------------tiregvsnvesfdqqlldsltligqdygdyvslwrKFDG 237 Dictyostelium disc...
Feature 1                                                                                     
AAD52851  203 MFFGLWDALHYLPAAKAFYWRLLEELYEDNVMYAELRVELFrlyte----ngrldREQSILQLWEVTEQFKKEhpd--fl 276 Glossina morsitans...
CAD37012  254 CFGVIGSMLHYEPIWRRFLRRLLQQLVEDGVYWVEVRFAWQldycregcttpepdYTAMFNVIEEEVAAFKATpegssfw 333 Neurospora crassa
EAA63979  231 CFLAIGGLFFTEPIFRRCIPRLLQQLHDDGIKYVELRLAPNpfyregs-neaepdFLYFLQCFQEEVDAYMSSptgrgfw 309 Aspergillus nidula...
P15287    213 YFAQVIGLLFYAPIMRDYYRQALEEFRADNVQYIELRSQLFgffeld---gtvhdAEFGLNLYKSVTEEFQREypd--fi 287 California sea hare
EAA04809  199 CFDAMKGFLQYKPFFEAYHWQLLHEFYNDRVYYIELRMSFAkvfdaa---greygPPEVAYLLHRIVDDFRRQhpa--fq 273 Anopheles gambiae ...
Q9NZK5    210 IFFTISGLIHYAPVFRDYVFRSMQEFYEDNVLYMEIRARLLpvyels---gehhdEEWSVKTYQEVAQKFVEThpe--fi 284 human
P58781    203 VFLVAYGLVTYAPVFKDYLYEGLRQFYEDNIMYVEIRALLPqtyeld---grlndKDWSMAACQEVVNQFKKHhpd--fi 277 zebrafish
EAA62652  215 SHQIPRGSRAISDIFDRRLPIINSILQYEPILRKCLRHIFSqlaadrisdkteedYTGWFQIFQEEVEKFRGTeegkefy 294 Aspergillus nidula...
BAB18576  258 HQRIIHGLITFRPIWSEFIFTMLSDFYADGVHYVELRSSLPnmydld---gnnftILETAEALVSVSNIFKNSfkd--fi 332 fruit fly
AAO52254  238 IFGRVNGLVTYLPIATGYMEHLFQQMIQDGVQHIEVRKCFGdfydlt---gkiydDYWFVQTMEELVLTTRQKynm-sef 313 Dictyostelium disc...
Feature 1                                                                                 #  #
AAD52851  277 GVRLIYTVLRgskpgelqeyysrLKNYTTRQPdkLVGFDMVGPEDS-DLRLLSFADNLIELSDKt-------KFFFHAGE 348 Glossina morsitans...
CAD37012  334 GLRMIWTTVRafgprtiiqsmndCIATKINFPhlIAGYDLVGPEDA-GRHLTDLLPELFWFRKQcaaegveiPFFLHAGE 412 Neurospora crassa
EAA63979  310 GAKIIWTAIRsfpddlikesmihCLNSKKAYPsvITGFDFVGQEDA-GRPLVDLLPLCKWFQQQcadeqlqiPFFLHAGE 388 Aspergillus nidula...
P15287    288 GAKIILSGLRfksqeeilnevkiAMDLHKKYPdfFLGYDLVGQEDP-NFSLLHYLDALLYPSIQnpp--yrlPYFFHAAE 364 California sea hare
EAA04809  274 GVKLILAKHRnmtdgelekalqlYDSLSTTFPgfVVGFDLVGQEDI-NRSLKSFSSLLVQPPVSsg----ppKYFFHAGE 348 Anopheles gambiae ...
Q9NZK5    285 GIKIIYSDHRskdvaviaesirmAMGLRIKFPtvVAGFDLVGHEDT-GHSLRDYKEALMIPAKDgv----klPYFFHAGE 359 human
P58781    278 GARVIFTVHRkinateavktveeAMILRRNFPdvMAGFDFVGQEDL-GRPLWYFKDALSLPEDKgf----nlPYFFHAGE 352 zebrafish
EAA62652  295 GARVIWATMRglsnkdiglsmeqCLLAKKMFPefICGFDLLGPEAN-EKPLNDLLPILFWFRGRcadegveiPFMFHAGY 373 Aspergillus nidula...
BAB18576  333 GIKLIYAPSRnlndsrmdeylenARLLKLHFPnfFAGFDLNTFGDEcNLPLLENVTQLLRIGKNi-------DFYFHAGE 405 fruit fly
AAO52254  314 ALKIIGCNGRhnnqsvvydamvmSLDLRNKYPstFVGYDLVGPEDE-GYPLIYFIEQFAEIKKLgyqyqyplDYYFHAGE 392 Dictyostelium disc...
Feature 1                              #                                                      
AAD52851  349 Tn--sYGGTDLNLVDAILLNTTRIGLGYALPKHPVLMKIVKAREIPVEVCPISNQVLHlvnDLRNHPGAILLANNIPMVI 426 Glossina morsitans...
CAD37012  413 Tlg-dGDAVDHNLFDALLLGARRIGHGFSLYKHPQLIKAVKDKRVLIESCPISNEVLRltgSIMQHPLPALLARGVPCAL 491 Neurospora crassa
EAA63979  389 Clg-dGNDTDSNLVDAILLNSRRIGHAFSLYKHPLLIDLVKDKNILIEMCPISHEVLRltsNILMHPMPALQARGVAVSL 467 Aspergillus nidula...
P15287    365 Tnw-qETEVDYNLADALLLNTTRVGHGFALIKHPRFTELAKENGVAVEVNPISNQILGlvrDVRNHALVPLIADDYPIVI 443 California sea hare
EAA04809  349 Iag-yFTEADENVIDAVLLDTKRIGHGYALMKHPILWHAVQHKQIAIEVCPISNQVLGlvrDLRNHPASFYVAQNIPIVI 427 Anopheles gambiae ...
Q9NZK5    360 Tdw-qGTSIDRNILDALMLNTTRIGHGFALSKHPAVRTYSWKKDIPIEVCPISNQVLKlvsDLRNHPVATLMATGHPMVI 438 human
P58781    353 Tds-qGTDVDQNLMDALLFNTTRIGHGFALARHPVVKEMARKMYVPIEVCPISNQVLKlvsDLRDHPAAVLMAEGHPLVI 431 zebrafish
EAA62652  374 Slg-dGDQTDDNLFDAVLLGTRRISQALSLYKHPLLIDVLKSKNILIECSPSSAACLGlsnSFQSHPLPALLSRGVSVAL 452 Aspergillus nidula...
BAB18576  406 SrcpdSSRPDANLLEALLLQSKRIGNAVNLPFHPEIMKVMKRLSIAVEICPLSNHYLQyfnDFRQHPAAYLIAAGFPIVI 485 fruit fly
AAO52254  393 T----ILYNNTNLYDAILLNTKRIGHGIQLPKHPLLMDLVLKNDIGIEICPISNQILQyvsDMRAHPGLDLLNRGLPVTI 468 Dictyostelium disc...
Feature 1       ##                                                                            
AAD52851  427 SNDAPAFWgv--qgLSYDYYYTIMslasnkagLSTLKQLVFNSIKYSAlpee-----------------ekkTAEKNLEK 487 Glossina morsitans...
CAD37012  492 CNDDPAILgqdmagMTHDFWQALQgwe--nlgLAGLGSLAENSVRWAAfedqtadewardvreasmgsgtkaERLKQWAV 569 Neurospora crassa
EAA63979  468 NNDDPAVLghgkngLSHDFYQVTAafe--ntgLAGLATMAEDSIRWAAfe---------------------dETDSEWLQ 524 Aspergillus nidula...
P15287    444 SSDDPGAWea--spLSHDFYVALMdlcgrdtaLTFLKQLALNSIRYSAmsdt-----------------ekvAAKAKWTT 504 California sea hare
EAA04809  428 TSDDPGFWda--vgVSFDYYYAFMaiap-hsgLGFLKQLVWDSIRYSSlsdg-----------------erqNITATMEK 487 Anopheles gambiae ...
Q9NZK5    439 SSDDPAMFga--kgLSYDFYEVFMgiggmkadLRTLKQLAMNSIKYSTlles-----------------eknTFMEIWKK 499 human
P58781    432 SSDDPAVFga--taLSHDFYEAFMgfggmsfnLGTLKELALNSLRYSTlssq-----------------rkeEAIDALLV 492 zebrafish
EAA62652  453 SNDSPGIYglgpngLSSEFYQALLafh--smgLSGLTMMVENSIRWSCye---------------------dKSVNDWNT 509 Aspergillus nidula...
BAB18576  486 GSDYPCFWns--apLTDDFYVAFVgvisgwgdLRLLKQFALNSFLFSSlset-----------------eknMAVSKWQC 546 fruit fly
AAO52254  469 SPDDPAIFny--ggLSYDFFEVTYswg---lnLQQLKQLAINSINHSNtfnq----------------seynLLYNAWEV 527 Dictyostelium disc...
Feature 1       
AAD52851  488 QW 489 Glossina morsitans morsitans
CAD37012  570 EW 571 Neurospora crassa
EAA63979  525 GI 526 Aspergillus nidulans FGSC A4
P15287    505 QW 506 California sea hare
EAA04809  488 QW 489 Anopheles gambiae str. PEST
Q9NZK5    500 RW 501 human
P58781    493 KW 494 zebrafish
EAA62652  510 DI 511 Aspergillus nidulans FGSC A4
BAB18576  547 SW 548 fruit fly
AAO52254  528 KW 529 Dictyostelium discoideum

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