Conserved Protein Domain Family
DHOase_IIb

?
cd01318: DHOase_IIb 
Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family.
Statistics
?
PSSM-Id: 238643
Aligned: 18 rows
Threshold Bit Score: 377.445
Created: 10-Jan-2006
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
 
active site
Feature 1:active site [active site]
Evidence:
  • Comment:active site is based on homology to other members of the amidohydrolase family

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                # #                                                                  
NP_713816  57 ETVIFPGFGDIHIHAREdesgkhtYKEDFVSASAAAVNGGVIHVADMPNNPIPPIdenSYSKKRKLAdrs-niHITLYAG 135 Leptospira interro...
Q9HIM0     45 DGAILPAATDIHVHFRTpg---etEKEDFGSGSLSAIYGGTTYVMDMPNNRFPITdynAFGDKLGSIdstsfaDFSLYSM 121 Thermoplasma acido...
Q9YFI5     54 SSLALPGVIDMHVHLRGlk---lsYKEDEVSGTAAAASGCVTLVADMPNTQPPLRtpeALREKLASLeagakvDYTVYAG 130 Aeropyrum pernix
Q9HMH9     42 DYRVLPGMIDAHVHFRQpg---feHKETWASGSRSAAAGGVTTVVDQPNTAPPTVtgdAVDEKAAHAaadsvvDWGVNGG 118 Halobacterium sp. ...
O27199     44 GYFVLPGLIDAHVHFRDpg---leYKEDFRTGSMAAAHGGFSTVLDMPNTVPPADnaaEFERKIRIGerksvvDFGLHAG 120 Methanothermobacte...
Q9UX05     43 GTLILPGAIDLHTHIRGlk---laYKEDVVSGTSEASYGGITLIGDMPNSVPFVNtmeTITAKLREFeyysrvDYFVYSG 119 Sulfolobus solfata...
Q8TSA6     49 GALTLPAGIDVHVHFREpg---mtLKENWYTGSCAAAAGGIATVIDQPNTIPPTTdrrSFEQKLKLArkksivDFGINGG 125 Methanosarcina ace...
Q8TXX9     50 RELAVPAPIDLHVHCRDph---pdYPFGFKTETRRFLLGGVATVVDMPNTRPAPTtpeTYYEKEELArenaeiEVIVAGG 126 Methanopyrus kandleri
Q8ZZC7     36 KYLILPGMVDIHVHFRDwg---lsHKETLRGGAAAALAGGVVAVGDMPNTKPHIRtadLYKKRLEEGsal-piIYKVHMG 111 Pyrobaculum aeroph...
O28034     37 KGVILPAGIDVHVHLRDfa---ekRKETIETGTLSALHGGICLVVDQPNTKPPVDdaeTYFRRMGKAeksvyvDYALNLA 113 Archaeoglobus fulg...
Feature 1                                                                     #               
NP_713816 136 IGp-----dTKPLKks-------vPYKVFMGPsigelff--hnnqtlEDTISSyvg---enVSFHCEdpeilekhqnetf 198 Leptospira interro...
Q9HIM0    122 ETgk----nAMLLDrr------siGLKVYLGGstnstgtevieegdiRKINEMny-----pVVFHGEserclkthqmeek 186 Thermoplasma acido...
Q9YFI5    131 VPrsy-geaVEMASmg------iaGFKIYPEDlvnlds----iknvlEAAEEAgi-----lVVLHPEshdmfagpdygwl 194 Aeropyrum pernix
Q9HMH9    119 VTgew--dpASLFDrsl-----faLGEVFLADstgdmg----idaalFRDACQraasedvvVTVHAEdadrfdtaaksrs 187 Halobacterium sp. ...
O27199    121 FRsvs--dvKGILRfm------paSFKVFMDLtgist------vdglFRELKDlsa--pvpVTVHCEnrdvvmksmkelk 184 Methanothermobacte...
Q9UX05    120 VTk-----dLKKVDkfp-----iaGYKIFPEDleke--------etlEVLKSMk------lKILHPEvplalrgnrk--- 172 Sulfolobus solfata...
Q8TSA6    126 VTgni--ekLRELWrlg----vtaFGEIFMAEstggln---ineetfEEALAEikkl-galATIHAEdekmrleleqllk 195 Methanosarcina ace...
Q8TXX9    127 VRds---qcTKELVeag----ayvLGEVFLATstdapa---vpwstlPEIFRElspd-gplTIFHPEldelvaerparnl 195 Methanopyrus kandleri
Q8ZZC7    112 IPq-----dLEELRaar-----ppTIKIYPEDveafg------wghiEKAAEAcasl-gcrLVLHCEdpayfkegerp-- 172 Pyrobaculum aeroph...
O28034    114 LTnsnhgkiGSIMRkiseryfvpaVGEVFIQHdsedlq---idyetlSSVYKRfeg---vvFTIHAEdpayvargsp--- 184 Archaeoglobus fulg...
Feature 1                                              #                                      
NP_713816 199 h-------edrrpaeaettatdFALYliek---ynlrGKLCHYSTgeGLNKIkfakq------kgvkvTCEVTPTHLFFD 262 Leptospira interro...
Q9HIM0    187 nl------rdhnlarpidceieAAKYvsgl---diktKIMAHVSSpdVTGNF----------------LREVTPHHLLLN 241 Thermoplasma acido...
Q9YFI5    195 r--------rvarpchaeaasvELLHdaarecgckprVHITHASCpaTVVESkkr-----------gfTVDVTPHHLFLS 255 Aeropyrum pernix
Q9HMH9    188 dad---awsayrtpeaeaaaveRAVEvgte---agatIHIAHTSTpeGVDAAaag-----------gaTCEATPHHLFLS 250 Halobacterium sp. ...
O27199    185 drsdpsayalarpplaeevsvaEVLAlsih---hehpVHICHLSTvkALQLVepfr---------eyvTCEVTPHHLLLD 252 Methanothermobacte...
Q9UX05    173 -------------lrlniwyeiGALYyvkg----yqnVHITHATNirTVRLAkel-----------gfTVDITPHHLLVD 224 Sulfolobus solfata...
Q8TSA6    196 gdvsydyhskvrpnaceasavqSALElisr---lqvrAHFCHLSTleAVGMIrkekylakrenkkplfTCEVTPHHLFLS 272 Methanosarcina ace...
Q8TXX9    196 yeh---lknrppeaettavgllAGLKvry-----psrIHLSHVTLpeSVKIAkga-----------diTVDVTPHHLFFD 256 Methanopyrus kandleri
Q8ZZC7    173 -----------piaelacvertRQMAfkt-----gvkIHLTHITLsqTAEAArg------------waTVDATPHHLLLD 224 Pyrobaculum aeroph...
O28034    185 -------------nfvfrrreaEVLAverlv--elgkFHFCHISTkdSAKEIlns-----------nsTYEVTPHHMLLS 238 Archaeoglobus fulg...
Feature 1                                              #                                      
NP_713816 263 rsmltpenrhwFQMNPPLRskedreRMLEGVkqgwIDYLATDHAPHSIEEKrkg----tsGISQLDTYSLFVTWLVLKAg 338 Leptospira interro...
Q9HIM0    242 demp---lgsfGKVNPPLRdsrtqkRLLDDYisgkFDILSSDHAPHTEDDKrefe-faksGIIGVETRVPLFLALAQKKi 317 Thermoplasma acido...
Q9YFI5    256 eeevagpthswGKVNPPLRgvgersLLTQLTieglVDAIASDHAPHSTWEKwmhpaiappGFPWLEWWPGFTAARLMRAv 335 Aeropyrum pernix
Q9HMH9    251 rddld-dlgtfGRMNPPLRsdprreALFERLadgrIDVVATDHAPHTRAEKaadiwdapsGVPGVETALPLLLGAAHRGe 329 Halobacterium sp. ...
O27199    253 sgafr-rfgtmVKTNPPLRppe-srIYPEFLd--rINIIGTDHAPHGIEEKrkgiwdappGIPNLEVVLKLLLTLVSKGr 328 Methanothermobacte...
Q9UX05    225 rek-----eclTKVNPPIRdtnerlWLLQAIn--eVDTVVSDHAPHASFEKqqpyeicppGIAALSFTVPFILTLVSKGi 297 Sulfolobus solfata...
Q8TSA6    273 akdwe-rlrafGKMNPPLRgshsikALVNGLndgtIDMVASDHAPHLESEKdldiraapsGVPGVETLMPLMLAAVRKNi 351 Methanosarcina ace...
Q8TXX9    257 vlrvd-pedpvFKVNPPLRgrhhrlGLLRAVrrgdVDVLASDHAPHILEDEfed---vpsGVTGGEIILPAALTLHRRFg 332 Methanopyrus kandleri
Q8ZZC7    225 venck--dsglCHVNPRLRtpemrkRLLAAFasglVDIYATDHAPHTLEEKrsga--pppGICSLDVALSLLLTLWKRGv 300 Pyrobaculum aeroph...
O28034    239 vedyg-rlgnlVNVNPPLReredveWLFRNFh--rIDVLASDHAPHTLEDKeag----asGFPGVETMYPLFVNLASKGy 311 Archaeoglobus fulg...
Feature 1                                                                                     
NP_713816 339 veLKTVARIcAKNPGDFvneylpekfgkgfgriepGYSANFTVLNLKkpkkflkeeiksKSGWSPFENFef--------p 410 Leptospira interro...
Q9HIM0    318 vpLDVLYRTaIENPPSIfgikk--------gkieiGYDADFMVIDFTsmkrindnrlhsKFPVSPFNGMd---------a 380 Thermoplasma acido...
Q9YFI5    336 -gLERFYSMvSQTPSTIlgvgd--------rclwdGCPATISVLQLErtrvy--hkgytKALYTPVLGMesfdcaatvir 404 Aeropyrum pernix
Q9HMH9    330 lsYERVRDVtAANPADVfglerk-------ghiaaGRDADLVLVDPDdareihgddlhsNCEWTPFEGHv---------g 393 Halobacterium sp. ...
O27199    329 msLSTIRRMlAEEPARIfglrsk-------griaeGMDADFTVIDLKetgrirsdefysKAHYTPFEGFsy--------t 393 Methanothermobacte...
Q9UX05    298 isIDRAVELiSTNPARIlnipy--------geikeNNYANFTIIQFKdwrys---tkysKVIETPLDGFpl--------r 358 Sulfolobus solfata...
Q8TSA6    352 lpLSQMIMVtSWNPAKAfgldrlg-----kgwlevGFDADLMIVDPRnlqpiradmlhsKAGWTPFEGMd---------a 417 Methanosarcina ace...
Q8TXX9    333 lsLRDAVAMiTCRPAKLlgrddl-------gevavGKRARITVVRMRefvvra-eefgeEDRKFPYDGMrm--------f 396 Methanopyrus kandleri
Q8ZZC7    301 vtLSDVVRLySHRPARFfdl------------qidVKKGYFTVVRLEeftvrg-eefagTCKHTPFEGFka--------f 359 Pyrobaculum aeroph...
O28034    312 isFKTLVEKiASNPARIfgfkgy-------geievGNYANFAVFDLKkvdeiraerlhsKCGWTPFEGFe---------a 375 Archaeoglobus fulg...
Feature 1               
NP_713816 411 GSIEAVFFLG 420 Leptospira interrogans serovar lai str. 56601
Q9HIM0    381 IFPSHVIMRG 390 Thermoplasma acidophilum
Q9YFI5    405 GKIAYTAWEG 414 Aeropyrum pernix
Q9HMH9    394 VFPAMTLVRG 403 Halobacterium sp. NRC-1
O27199    394 GGPVMTIVRG 403 Methanothermobacter thermautotrophicus str. Delta H
Q9UX05    359 ASIYMTIIQG 368 Sulfolobus solfataricus
Q8TSA6    418 VFPEYTLSRG 427 Methanosarcina acetivorans
Q8TXX9    397 GEPVKLIDGT 406 Methanopyrus kandleri
Q8ZZC7    360 GRVFATSVGG 369 Pyrobaculum aerophilum
O28034    376 VFPDKVYLRG 385 Archaeoglobus fulgidus

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap