Conserved Protein Domain Family
AdeC

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cd01295: AdeC 
Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source in bacteria and archea.
Statistics
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PSSM-Id: 238620
Aligned: 25 rows
Threshold Bit Score: 477.872
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
active site
Feature 1:active site [active site]
Evidence:
  • Comment:active site is based on homology to other members of the amidohydrolase family

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                   # #                                                               
Q58854     53 DLKGKYLSPTFIDGHIHIESSHLIPsEFEKFVLKSGVSKVVIDPHEIANIAGKe-GILFmln---daKILDVYVMLPSCV 128 Methanocaldococcus...
NP_356229  78 DAGGAYVSPGLIDTHMHIESSMITPaAYAAAVVARGVTTIVWDPHEFGNVHGVd-GVRWaaka-ienLPLRAILLAPSCV 155 Agrobacterium tume...
NP_562184  50 DGEDKYIIPGLIDIHMHIESSMTIPrEFSKAAIKHGVTTVVADPHEIANVFGVr-GIEEfik---fkGNLDIFYGIPSSV 125 Clostridium perfri...
NP_102016  81 DAGGRYLVPGLCDAHMHVESGMVTVtEFCRAVIPHGTTSMFIDPHEIANVLGLp-GVRLmhde-avaMPINVHVQMPSCV 158 Mesorhizobium loti
NP_814949  50 NAENQWMIPGLIDAHMHIESSMTTPtIFSKAVVRYGVTTVIADAHEMANVFGLe-GLKAfma---aeTELDIFHAIPSSV 125 Enterococcus faeca...
NP_614112  94 IDVDGIICPGFVDAHVHVESSGLRPaRYAEIVVREGTTAVVWDPHEVVNVSGEl-GLEWavktaeeaLPFKFYIALPSCV 172 Methanopyrus kandl...
NP_436190  65 DAADRYLTPGMIDGHLHVECSKLSLtSFAKAVLPLGTTSIVSGLDQIIVVGGPd-AAREflde-vrqTPLKVFWGAPCKT 142 Sinorhizobium meli...
NP_769805  79 DAAGAIIAPGLVDPHIHIESSMVTAcAYAEAALLNGTTTIFCDSHEIGNVMDVa-GVEAmled-arqAPLSIFLTVPSTV 156 Bradyrhizobium jap...
NP_241503  74 DCGQQVIVPGYIEHHAHPFQLYNPH-SFANYAAAMGTTTLINDNLMFFLALEKkkALSMies--ldeLPSSMYWWCRYDP 150 Bacillus halodurans
O34909     73 DCEGKYIVPGYIEPHAHPFQIYNPQ-TLAEYVSQYGTTTFVNDNLFLLLQSGKkkALTIlne--lkkQPVQYFWWSRYDL 149 Bacillus subtilis
Feature 1                                                                        #            
Q58854    129 PATnle--tsGAEITAENIEELILld-nvLGLGEVmnypa-vinedEEMLKKIEVAKky--nkLIDGHCPKLk-gWELNK 201 Methanocaldococcus...
NP_356229 156 PSApgl-ergGADFDAAILADLLSwp-eiGGIAEImnmrg-vierdPRMSGIVQAGLaa--ekLVCGHARGLk-nADLNA 229 Agrobacterium tume...
NP_562184 126 PSTssslettGEKITHNEVKRLLEyd-niICLGEVmnfkdliedddSNINKIINISKek--niPLEGHCPKIq-gVDLSL 201 Clostridium perfri...
NP_102016 159 PSApgl-ehaGAELTVADVAEAMTwe-niIGLGEVmnfpg-vaandPVMSGEIAATVra--gkTVGGHYASRdlgLPFHG 233 Mesorhizobium loti
NP_814949 126 PSTtpelettGGIIGLAEVAELLKep-kvICLGEAmnfkgisyepdSLIRQIIDLCQkqrptmPLEGHCPKIe-dQELAD 203 Enterococcus faeca...
NP_614112 173 PALgppyetvEGEITVDVARKFAShp-mvVSVGELmdvag-vmegeKDEFIELKSLYg----lTVDGHAPGLt-gFEAMR 245 Methanopyrus kandl...
NP_436190 143 PYTmpr-stvGHYFSPKDHRDTHHwp-ecVGIWETvrefi--qeedEDVLQAIEIGQan--rlPVLGCCPMTr-gARLNG 215 Sinorhizobium meli...
NP_769805 157 PATsaeletaGGDLTPDKIAGLFDrwpeaVALGEKmdfvp-vtmgdERSHAILAAALkr--grPVSGHVYGR---EFVAA 230 Bradyrhizobium jap...
NP_241503 151 QTEmn---deEGHFLNSKIKEWLEhp-lvVQGGELtswpk-vitgdDGILHWMQETRrl--rkPIEGHFPGAs--EKTLT 221 Bacillus halodurans
O34909    150 QTEvl---neDHVLPFDVRKQWIEhp-dvIQGGEMtgwpr-lvdgdDLMLHCMQATKkq--rkRIEGHFPGAs--DKTLT 220 Bacillus subtilis
Feature 1               #                                                       #             
Q58854    202 YIs-hGIMSDHESVDedeALEKLRLGLKLMIREgta----skNIYLLNickki---kdfrnIMLVSDDVCIKDLd--GYM 271 Methanocaldococcus...
NP_356229 230 FMa-aGVSSDHELVSgedLMAKLRAGLTIELRGshdh--llpEFVAALntlgh----lpqtVTLCTDDVFPDDLlqgGGL 302 Agrobacterium tume...
NP_562184 202 YIy-rGVNGDHTQQSvgsLQEKIQNGMFIEMQHksm---tleNIKFLIennl------yehFALVTDDVMADKLv-kGHL 270 Clostridium perfri...
NP_102016 234 YVa-gGPEDDHEGTRaedAIARVRQGMKAMLRLgsa----wyDVASQIkavteg-gidprnFILCTDDSHSGTLvheGHM 307 Mesorhizobium loti
NP_814949 204 FLy-sGITSDHTHQFpktLKEKIEAGVFIQFQNksi---tpeNIQVIVdndf------ynyASIITDDVMADDLl-kGHL 272 Enterococcus faeca...
NP_614112 246 YFa-aGPETDHECSTaeeFTSRRELGVWTFVRQgss----skDMEVALetle-----dlrgVCFVTDDLHVKDMd-eISL 314 Methanopyrus kandl...
NP_436190 216 YMq-sGVRADHESYTpeeMLEKLRAGMHVVVREssishflsdNLRIVTemgvk----alrrISFCTDDVVASDIlsrGHL 290 Sinorhizobium meli...
NP_769805 231 YAa-sGVTDTHEAIDrdiADDLLDAGVWVFLRGgppt-tpwhSLPQAIrtitel-gashkrTAVCTDDRDADDLl-lFGL 306 Bradyrhizobium jap...
NP_241503 222 QMsllGVTSDHEAMTgeeVIRRLDLGYMTSLRHssi----rsDLAKILremkelgiddfsrCMLTTDGSPPSFYe-qGIM 296 Bacillus halodurans
O34909    221 KMklfGADCDHEAMTgdeVMRRLELGYYVSLRNssi----rpDVRKILqelhekgfryydhFFYTTDGATPNFYk-gGMT 295 Bacillus subtilis
Feature 1                                                                                     
Q58854    272 LNILRKATNyvs-piEAIQMVTINPANYfgf--dvGIKAGNE-ASFVIFEDLDNFKVYNIVIKGrflddvlnelnknkkr 347 Methanocaldococcus...
NP_356229 303 DDVVRRLVRyglkpeWALRAATLNAAQRlgr-sdlGLIAAGRrADIVVFEDLNGFSARHVLASGravaeggrmlvdiptc 381 Agrobacterium tume...
NP_562184 271 DEILKEAVKlgmsieNAIYASTYTPARRmnl-ldrGTIAPGKlADFILLDSIEDFNIYEVYKNGemvfnrdkglkeeffe 349 Clostridium perfri...
NP_102016 308 DRVVRHAIQqglkpvTAIQMATINTAQHfrlereiGSIAPGRlADLLIVSDLAAMTIDEVYARGvrlakggkldidipay 387 Mesorhizobium loti
NP_814949 273 NENVKKAVHaglpieKAIYMATYTPAKRmgl-hdrGEIAPGKkADFLLLNDLESFDINTVYKSGkvvfekgepfhypeki 351 Enterococcus faeca...
NP_614112 315 RKIVGRAIEagfdplESLSAVTLNPSLCygl--qsGRLVPGFhADIVVVEDLDENMELTDVWIGgkrservrfrdaeael 392 Methanopyrus kandl...
NP_436190 291 DNMVRMAMAmgispmAAIQMATINGAEAlridhkvGSISPGRtADILIVNDLRDFRIEAVVANGtvaardgrmvvklvpp 370 Sinorhizobium meli...
NP_769805 307 DWVVREAVKagmspeQAWSMGSLHGATRfgmegdiGGLGGGRrADLVLMDDQLKPQCTWYGGELvvehgkitprldqals 386 Bradyrhizobium jap...
NP_241503 297 DRLIKIALDegippkDAYGMATYYVARYygldyelGMIAPGRiAHLNFLDNVFNPVPTSVLAKGqwvvrdgqrygsdsvf 376 Bacillus halodurans
O34909    296 NELIRIALEegvpaiDAYNMASFNIAKYyqmddylGVVGPGRlASLNILEDPLNPNPVTVLSKGtilrengcdlkaftkt 375 Bacillus subtilis
Feature 1                                                                                     
Q58854    348 kipeklmntlkyqyknegdflikgid-----ykerdgfirvikplkdsliteelifsteeikillnenainkIFVIERHK 422 Methanocaldococcus...
NP_356229 382 dttvlkgsmklplrmandflvks-----------qgakvrlatidrprftqwgeteadvkdgfvvppegatmISVTHRHG 450 Agrobacterium tume...
NP_562184 350 dkskldyrfynsielnnitkeslevkvpnkyknkvncrtmkvlknttfteegevtlnvynnilqweksscalIAVFERYG 429 Clostridium perfri...
NP_102016 388 dypktakntvklgkklragdfditapk--ganevrvrvigvienqaptraleadlpvedglvamdrrndvcqIALVERHR 465 Mesorhizobium loti
NP_814949 352 eefpatyqqtiqckklteedlllkvat---tketvrcnviqkqeigtfteritkeipvengllqwqkancalLIVMERYG 428 Enterococcus faeca...
NP_614112 393 pdvelsvdprevsfqdgky------------------evrcvglvrgsirteeivreitvkdgavkdddvafLVVTDRYG 454 Methanopyrus kandl...
NP_436190 371 qrsagllrsvkttpvtaadiavpftgt--tpfaevlaiavtpekvfvrtrrdvrlpvvdgkiladasqnvqyVTVVERYG 448 Sinorhizobium meli...
NP_769805 387 qryqypkaayatvklpekvkltpelp----akactvnaiktalpgitlihekvaiepakdwptlfaryglcfVTVVERHG 462 Bradyrhizobium jap...
NP_241503 377 pwedfgmkrltidwdlsvdelh-------------fsmpmgielvnsvilkpyqvsveasrdtlaedhdecfFLLLDKHG 443 Bacillus halodurans
O34909    376 dwhkgglvplelsydmtmddlq-------------fsmpmgvkmrnavimepymieidnsmeqlsfdhdesyLTMLDRHG 442 Bacillus subtilis
Feature 1                                                                                     
Q58854    423 ntgn-igkGLIYNFLEe--GALASSYaHDSHNVIAIGnneKDLALAVNKLKDIGGGFIAAKDGevVEYLPLPVGGIMGdd 499 Methanocaldococcus...
NP_356229 451 maepttktGFLTGWGRw-nGAFATTVsHDSHNLTVFGgnaGDMALAANAVIGTGGGMAVASEGkvTAILPLPLSGLVSda 529 Agrobacterium tume...
NP_562184 430 knnn-isfGLVEGEIIk-eGAIATTWaHDHHNLMVMGrniSDMTIAANEVINSRGGYVVSKNNevIAKLELPIGGIISde 507 Clostridium perfri...
NP_102016 466 gtgg-vtnAFVSGFGYmgdCAMASSVaHDAHHIICVGtnkQDMALAVNRLGQVGGGVVLFSKGkeLALVEMPIAGLMSde 544 Mesorhizobium loti
NP_814949 429 kngn-isfSLMDQPLSe-kGAIATTWaHDHHNLMVMGntiEDILLAQNELLAMQGGYLVASDQqvMATCPLPIGGILSqa 506 Enterococcus faeca...
NP_614112 455 qgs--wsiGFVEGFEEl-dCAVVSTVaHDSHNVVVAGrrlDDVRRALQLVSEVGGCVGAVAGDr-AEFVRLDVAGLMSss 530 Methanopyrus kandl...
NP_436190 449 ktln-rpvAFVSGFNLk-sGAIASSTaPDDNNIICIGadpQDMAIAINHLVANNGGQVVVDKGevVEFLHLPIGGIVSdi 526 Sinorhizobium meli...
NP_769805 463 ksagnvayGLLKDFGLk-rGAVASSVgHDSHNIIVAGtnePDMQVAIAAIKEHQGAVCVVADGkvRALVPLPIAGLLSdk 541 Bradyrhizobium jap...
NP_241503 444 kwk---ipTMIKGFAKk-vSGLASSF-STTGDIILIGkciQDMIVAFNALKQQGGGIVLVENGevISNIPLEIMGLLSsk 518 Bacillus halodurans
O34909    443 kwr---vnTMIKGFASs-vQGFVSSF-TTTGDIVAIGknkADMLLAFARMKEIGGGIVLAENGniLHEIPLALCGCASse 517 Bacillus subtilis
Feature 1                                                           
Q58854    500 --gKYIAEKInaLYKKIEGWSsf-eNPFLSMS--FFSLPVIPELk-iTDKGLVK 547 Methanocaldococcus jannaschii
NP_356229 530 -plEEVARAFedLREAVGKVVew-qPPYLVFKacFGATLACNIGphqTDMGIAD 581 Agrobacterium tumefaciens str. C58 (Cereon)
NP_562184 508 -piEIIGEKLgeVRNAMRDLGynhmNEIMSFS--TLSLPVSPALk-iTDKGLID 557 Clostridium perfringens str. 13
NP_102016 545 -raEIVAAKAekLTEAMRKMGcslnNAYMQHS--LLALVVIPELr-iSDVGLID 594 Mesorhizobium loti
NP_814949 507 -piEQLGASLqkVRQAMQALGyqnmNEIMSFS--TLSLPVSPAIk-vTDFGMMD 556 Enterococcus faecalis V583
NP_614112 531 -dpEEVKKSYedVLELIRSSSgvdwDPFQALS--FVTLPVVPELr-lTDRGLVK 580 Methanopyrus kandleri AV19
NP_436190 527 dpaEMAAFELr-LDEAARRLGcdlpWPFMYMF--VLQITAIPDYa-mTDLGVVD 576 Sinorhizobium meliloti
NP_769805 542 -rvTEVAEEVkvLKKEWAEAGc--tIPYMGFN--LIPLSVIPEIr-iTDKGLVL 589 Bradyrhizobium japonicum USDA 110
NP_241503 519 -pmEEVMEEEkkFVKALRERGyehdDPIYSLL--FFSSTHLPYIr-vTQRGIYD 568 Bacillus halodurans
O34909    518 -ayEDVLEKEqkLRDLLTERGyefcDPIYTLL--FLQSTHLPYIr-iTPRGIFD 567 Bacillus subtilis

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