Conserved Protein Domain Family
Riboflavin_deaminase-reductase
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cd01284: Riboflavin_deaminase-reductase 
Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the biosynthesis of riboflavin.The ribG gene of Bacillus subtilis and the ribD gene of E. coli are bifunctional and contain this deaminase domain and a reductase domain which catalyzes the subsequent reduction of the ribosyl side chain.
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Statistics
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PSSM-Id: 238611
Aligned: 33 rows
Threshold Bit Score: 119.261
Created: 3-Feb-2003
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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catalytic motifZn binding site
Feature 1:catalytic motif [active site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                     ###                               
P17618        6 MKLALDlakqgegqtesNPLVGAVVVkd-gqIVGMGAHLky--gEAHAEVHAIHMAga---------------------- 60  Bacillus subtilis
NP_282750    16 MNLALNeawkyqfltypNPAVGCVILdknekILAIKAHEka--gLAHAELNAIAHAfkslrpeislpkean----alhef 89  Campylobacter je...
Q12362      439 MEMAVKeagkc-gptktAFSVGAVLVhg-tqVLATGYSRel-pgNTHAEQCALIKYsqlhpn------------------ 497 baker's yeast
AAD08541      8 LEMCLNkawehqtlaleNPSVACMVLdknheILSLETHKka--kTPHAEVLAAQSAlkilrpslkndlekledpktlsdf 85  Helicobacter pyl...
ZP_00108473   7 MLAALAqsrkalpeclpNPPVGCVNVdv-qeIVAQGYTQvp--gKHHAEADALKRIqgk--------------------- 62  Nostoc punctiforme
CAB09771    262 MLKALNeakkc-eptdsAFCVGAVIVqn-gkIVSTGYSRer-pgNTHAEECAIEKFmlknp------------------- 319 fission yeast
ZP_00058329  12 LRTAVDlsrsc-ppsstAFSVGALIVaadgtVLADGYSRrd-dpHDHAEEVALRAVaaed-------------------- 69  Thermobifida fusca
NP_628286   235 LALACElaelc-ppsdtAFSVGAVVVaadgsELARGHSReggdpVVHAEEAALAKVdped-------------------- 293 Streptomyces coe...
NP_419702    19 ALAAAEayag---atapNPPVGCVVLdaageTLAVAAHQra--gQAHAEAAALAACrerg-------------------- 73  Caulobacter cres...
ZP_00129464  11 MLEAVAlaekgrwatspNPCVGAVLVkd-gqTVARGWHTay--gKPHAEIECLRDAarrg-------------------- 67  Desulfovibrio de...

Feature 1                          ##          #                                     
P17618       61 -------haEGADIYVtLEPCShygk--tppCAELIINSGi-kRVFVAMRdpnp-lvaGRGISmMKEAG 118 Bacillus subtilis
NP_282750    90 icknhqgvfKDSIAFVtLEPCShqgk--tppCAKLFSELGf-kKIFISVKden--kiaSGGAEfLKKQG 153 Campylobacter jejuni subsp....
Q12362      498 ---cptivpMGTVLYTtMEPCSfrlsgnepcCDRILATQGaigTVFVGVMepdtfvknNTSLNkLESHG 563 baker's yeast
AAD08541     86 lkthhdnafTDCVFLItLEPCNsygk--tpaCSELLEILKp-kRVVIATEene---akKGGLArLQKAR 148 Helicobacter pylori 26695
ZP_00108473  63 -------gfNFLKMYVtLEPCSfhgr--tpaCALAIAEDCrihEIYVSILdpdp-rnnGQGLDiLRKAG 121 Nostoc punctiforme
CAB09771    320 -----tdslEGAIMYStMEPCSkrls-kkvsCTDLIVKQKf-sTVVLGSLepdi-fvkCEGVDlLKKAG 380 fission yeast
ZP_00058329  70 ------prlAAATLYSsLEPCStras-rprsCTSLILDTPi-pRIVFAWRepel-fvdCRGAElLRAAG 129 Thermobifida fusca
NP_628286   294 ------prlPGATVYSsLEPCArras-rpapCARLILDAGv-rRVVTAWRepdtfvagADGSGvLTAAG 354 Streptomyces coelicolor A3(2)
NP_419702    74 ------aaaRIDTLLVtLEPCNhhgr--tppCVEAILASPa-rTVWIAVRdpnl-avaGGGAArLEAAG 132 Caulobacter crescentus CB15
ZP_00129464  68 ------vnpAECTLVVtLEPCNhtgk--tppCSIAVLQAGi-rHVVVGMMdpn--pvaQGGANfLRENG 125 Desulfovibrio desulfuricans...

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