Conserved Protein Domain Family
HTH_MerR-like_sg3

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cd01282: HTH_MerR-like_sg3 
Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily
Putative helix-turn-helix (HTH) MerR-like transcription regulators (subgroup 3). Based on sequence similarity, these proteins are predicted to function as transcription regulators that mediate responses to stress in eubacteria. They belong to the MerR superfamily of transcription regulators that promote transcription of various stress regulons by reconfiguring the operator sequence located between the -35 and -10 promoter elements. A typical MerR regulator is comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their N-terminal domains are homologous and contain a DNA-binding winged HTH motif, while the C-terminal domains are often dissimilar and bind specific coactivator molecules such as metal ions, drugs, and organic substrates.
Statistics
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PSSM-Id: 133388
View PSSM: cd01282
Aligned: 28 rows
Threshold Bit Score: 123.871
Threshold Setting Gi: 88855962
Created: 30-Apr-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
DNA bindingputative dimer
Feature 1:DNA binding residues [nucleic acid binding site]
Evidence:
  • Comment:Based on sequence similarity to BmrR and the structure of Bacillus subtilis BmrR bound to DNA (1EXI).

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        ###             #               ###                                            
NP_463185     1 MQIGKLAALTGVSIRMLRYYESAGLLHPSRTDTGYRSFSSEDVDIVRRILILNGAGFTLPVVCSLLNCVhag-------t 73  Salmonella typhi...
NP_629575     1 MRIGELAARAGTTTRTLRYYESRGLLPARRGGNGYRTYDEDDLKLLRQIRTLQDFGFDLEETRPFVECLraghp----eg 76  Streptomyces coe...
NP_640674     2 LRIGALAQQTGASVRSIRHYDAHGLLTSSRSANGYRVFPHACVAQVRQIQRLIATGFNLDEILGFPDCMrlve-----ga 76  Xanthomonas axon...
NP_824725     1 MRIGELGRATGATPRALRHYERAGLIASRRAANGYRVYDEGTVTRVRNIRHLLAAGLTLDDVRVFLPCLdgdmt----ag 76  Streptomyces ave...
YP_626355    10 LTIGKLAQLTGASVRSIRHYDEHGLLASVRADNGYRLFPDKAVTQVKQIQRMIATGFTLDDIRGFPDCMllie-----ga 84  Burkholderia cen...
ZP_00572756   1 MRIGELARRAGTSPRALRHYEDQGLLATRRLANGYRDYSDADLRAVEEIRALLADGFALEETRPFVECLragne----ta 76  Frankia sp. EAN1pec
YP_479283     1 MLIGELAERAGTSTRTLRYYESHGLVRPRRSANGYRVYDETELRVVHEIRALLAVGFDLNDIRPFVACLragnt----sg 76  Frankia sp. CcI3
ZP_01461457   1 MNIGELSKLSGASARSIRHYEKSGLLVSRRRSNGYRDFGPEAVPRVQHIVRMIGLGFSLEEIGTFSPCMftre-----as 75  Stigmatella aura...
YP_713167     1 MQIGELARATGTTPRALRYYEEQGLLRPSRTGAGYRVYDDGAVTTVGTIRHLLASGFTVDDLRSLLALLdqplperfqpr 80  Frankia alni ACN14a
ZP_01140072   1 MRIGELASKTGVSVRVLRHYETQGLIKSQRLSNGYRDYHFHAVERVQWVRDLLACGFSTRQIREFLPCLeng-------- 72  Geobacter uraniu...
Feature 1                                            
NP_463185    74 spCEELK-AKVREQLAQIDRQFDALSESRNLLNKFLN 109 Salmonella typhimurium LT2
NP_629575    77 dsCPASL-VVYRRKLAELDTLIEQLTSVRAQVAAQLT 112 Streptomyces coelicolor A3(2)
NP_640674    77 qmCPETA-QAHRARLQLIERQLADLERRRARLSATLA 112 Xanthomonas axonopodis pv. citri str. 306
NP_824725    77 paSARAL-GVARERLAVIDERIAAQLAVRERLAAALR 112 Streptomyces avermitilis MA-4680
YP_626355    85 rsCDQIT-DVQRERLEAIDRQIADLEKRRARLVKMLR 120 Burkholderia cenocepacia AU 1054
ZP_00572756  77 asCPDSI-EGYRRKIAQIDDYVARLLRSRERLAAQLA 112 Frankia sp. EAN1pec
YP_479283    77 hvCPDSV-LVLRRKLAEVDVCIKRLDAVRQQLQSQLA 112 Frankia sp. CcI3
ZP_01461457  76 giCPDAL-ATHQAKLADIERRISDLESRRARLVETLT 111 Stigmatella aurantiaca DW4/3-1
YP_713167    81 paCADAL-AVAVRRLDALEERIADLTALRDRLAHRLG 116 Frankia alni ACN14a
ZP_01140072  73 niDPQKCtAKHIAKLQELDEMINLLTERRRRLSERLA 109 Geobacter uraniumreducens Rf4

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