Conserved Protein Domain Family
HTH_HspR-like

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cd01279: HTH_HspR-like 
Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators
Helix-turn-helix (HTH) transcription regulator HspR and related proteins, N-terminal domain. Heat shock protein regulators (HspR) have been shown to regulate expression of specific regulons in response to high temperature or high osmolarity in Streptomyces and Helicobacter, respectively. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. A typical MerR regulator is comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their conserved N-terminal domains contain predicted winged HTH motifs that mediate DNA binding, while the dissimilar C-terminal domains bind specific coactivator molecules.
Statistics
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PSSM-Id: 133387
View PSSM: cd01279
Aligned: 3 rows
Threshold Bit Score: 124.632
Threshold Setting Gi: 2506567
Created: 30-Apr-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
DNA bindingputative dimer
Feature 1:DNA binding residues [nucleic acid binding site]
Evidence:
  • Comment:Based on sequence similarity to BmrR and the structure of Bacillus subtilis BmrR bound to DNA (1EXI).

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1       ###             #               ###                                           
P40183     17 VYVISVAAQLSGLHPQTLRQYDRLGLVSPDRTAgRGRRYSaRDIELLRQVQQLSQdEGINLAGIKRIIElenqvaeLQAR 96  Streptomyces coeli...
YP_430303   6 LYPISVVAELLGIQPGTLRVWERHKLIQPARKN-GRRLYSnNDLKRLRFIKRLID-KGFNLNSLKHYLAfypcwllEDCP 83  Moorella thermoace...
CAB08585   12 TFLISVAAELAGMHAQTLRTYDRLGLVSPRRTSgGGRRYSlHDVELLRQVQHLSQdEGVNLAGIKRIIEltsqveaLQSR 91  Mycobacterium tube...
Feature 1                       
P40183     97 AAELAAALDGAATAMRQR 114 Streptomyces coelicolor
YP_430303  84 SCSHKTERIGCAKPCWKE 101 Moorella thermoacetica ATCC 39073
CAB08585   92 LQEMAEELAVLRANQRRE 109 Mycobacterium tuberculosis H37Rv

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