Conserved Protein Domain Family
DszC

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cd01163: DszC 
Dibenzothiophene (DBT) desulfurization enzyme C
DszC is a flavin reductase dependent enzyme, which catalyzes the first two steps of DBT desulfurization in mesophilic bacteria. DszC converts DBT to DBT-sulfoxide, which is then converted to DBT-sulfone. Bacteria with this enzyme are candidates for the removal of organic sulfur compounds from fossil fuels, which pollute the environment. An equivalent enzyme tdsC, is found in thermophilic bacteria. This alignment also contains a closely related uncharacterized subgroup.
Statistics
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PSSM-Id: 173852
View PSSM: cd01163
Aligned: 15 rows
Threshold Bit Score: 416.724
Threshold Setting Gi: 32404522
Created: 26-Mar-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Flavin binding
Feature 1:Flavin binding site [chemical binding site]
Evidence:
  • Comment:based on similarity to acyl-CoA dehydrogenases

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                       
BAC20182     20 EVARELTRKWQATVVERDKAGGSAtEEREDLRASGLLsvtvPRHLGGWGADWpTALEVVREIakvDGSLGHLFGYHLSTP 99  Bacillus subtilis
XP_322874    39 QRAKDVAAVLAPDAAAREKANRTPrAEVALLKHSGLLkilgPKEYGGGEQPWsVAYQAIREVakgDGSIGMLLGYHLLWA 118 Neurospora crassa
ZP_00032686  22 RDLASLLDALHASAAQRDLEGGHAaQEKQWIADAGLLtlavPREFGGLGARWpDIYETVRKIaqvDSALAHLLGFTCLQV 101 Burkholderia fun...
ZP_00057322  32 TRAAEVGAILAADAVERDRAGQTPyAEVQLLKDSGLVtllgPVEYGGGGQTWeTAYRVTREVskaDGSIGQLLGYHYLWS 111 Thermobifida fusca
BAC66052     14 AIARELAGQFAQTAVERDDRGGTPkAERDALRDSGLLslviPQAFGGQGASWhDTFAVVREFarvDSSIAHVFGFHHLML 93  Pseudomonas putida
NP_105924    36 AIAHALAAEFVKESSRRDRERVWPvAELDAFSQSGLWsinvPKAFGGPEVSYaTLAKVIEIIsaaDSSIGQIAQNHLGVV 115 Mesorhizobium loti
ZP_00024019  71 QRAQALLPRIAEGAAIRELQRDLPyAFAREVANAGLLtfriPKVYGGPGGTLrDAIRFVIELaavDSNLAQALRPNFGLV 150 Ralstonia metall...
ZP_00032429  28 RRFAPVFARIAEGALEREQRRELAyEPVEWLREAGYTrlrvPKRYGGEGISLtQFFALVTRLgeaDSNLPQILRAHGGFI 107 Burkholderia fun...
NP_600240     7 SHFAPALERIRSGAVEREQQRALPvEEIKELVELGFTglrvPEELGGAGASLeSVVELLIEIagaDSNIAQALRGHFAFV 86  Corynebacterium ...
NP_251014    25 QRFRPIFARIAEGAVERERQRELPhEAIAWLKQAGFGavrvPREHGGAGASLpQLVQLLIELaeaDSNITQALRGHFAFV 104 Pseudomonas aeru...
Feature 1                                                                      # #              
BAC20182    100 AVIDLWgsPEQSERLLRQLAENNWWTGNASSEnnshi--lewkVTATPTd--dGGYLLNGIKHFSSGAkGSDLLLVFGVI 175 Bacillus subtilis
XP_322874   119 FSSSILgtPSQITKWTALITSQNLFVGGAVNPrd-------sdLVITADpnnsAKIIFNGSKHFTTGAaVSDLIVLEGSL 191 Neurospora crassa
ZP_00032686 102 VSVNVWgnPEQRARFLSGTVENRWWWGNAVNPld-------trLIATASg--dGGYLLDGQKGFCSGTrGSQMMTVSAQD 172 Burkholderia fun...
ZP_00057322 112 WAVRFLgtPQQIAAVEELATTNRYFFGGAVNPrd-------ddLVITEDg---DTLVFNGRKTFSTGSkVSDLTVLEGVL 181 Thermobifida fusca
BAC66052     94 ATVRLFsrPDQWQPWFEQTARKQWFWGNALNPld-------trTVVKHFd---GWCEFSGKKSFCSGAsDSEMLIASAVD 163 Pseudomonas putida
NP_105924   116 AAIRTVs-DADQQKLLFAEVLNGTRFGNAFSEfgskr-aadfeTRFTDAg---DHVVVNGRKFYSSGAlLAHLVPIVALD 190 Mesorhizobium loti
ZP_00024019 151 EGLLAAhdNEADRKRWFGRLLAGHIIGNGGVErggk---qgaiQATIVRh--gDHYLVNGTKYYSTGGlYADWVSSIALD 225 Ralstonia metall...
ZP_00032429 108 EALLENg-DESLRERWFTKIVQGQIVGGAVSErtgv---tnnsVRLTQTd---GAWYLDGEKYYTTGTlYADWVDVTAHD 180 Burkholderia fun...
NP_600240    87 ELLLEAp-ESEFRTHWLREVATGRLVGNAESEkrgvygdpqtfIDEVETen-gPIFVLNGTKFYTTGTyFADYTWTTALL 164 Corynebacterium ...
NP_251014   105 EDRLNAe-PGPGRDRWLRRFVEGDLVGCAWTEvgsvr--lgevLTRVSRkd-dGRWVVNGSKYYSTGSlFSDWIDLYAQR 180 Pseudomonas aeru...
Feature 1                                                                                       
BAC20182    176 pegs--pqqgAIVAAAIPTtreGVQTNDDWqaLGMRRTDSGTTEFHNVVVRPDEVLgkpnavveafla---sgrgslfgp 250 Bacillus subtilis
XP_322874   192 ssssfpesggAHIFAYVPTtdpGITFSFNWdaIGLRLTESGSAQISNVVVSWEDALgwdastkqplpdilgvpfatlllp 271 Neurospora crassa
ZP_00032686 173 pv------tgKPVFGVLPTtreGITVHEDWnpIGQRQTDSGSVSFVRVKLEPHEVMerpdtpha-----------slrtl 235 Burkholderia fun...
ZP_00057322 182 eg------tdQHIFAIVPSaqdGIVFADDWdnIGQRLTESGSVRITNVRISWDDAAgyvnrefrpl------vyntlnlp 249 Thermobifida fusca
BAC66052    164 era-----ggKLLIAAIPSgrtGISLHNDWnnIGQRQTDSGSATFERVRVEHNELLldpgplstp--------faalrpl 230 Pseudomonas putida
NP_105924   191 de-------gRAWYAIADRgapGLTVIDDWssFGQRTTLSGTVIIDNVKVPKTFLVpgykgydr----------ptadga 253 Mesorhizobium loti
ZP_00024019 226 ea-------gKETHFTVPReraGMELVDDFdtIGQRLTASGTTRFTNMRVETDEVRgsflprdr----------rnpvsp 288 Ralstonia metall...
ZP_00032429 181 g--------tSDVRVLVETgtpGLERIDDWdgFGQRLTGSGTARFTRVPVSPDNLYrrynaaepr--------rnsllta 244 Burkholderia fun...
NP_600240   165 rnln---gqeTLVSLPVDLhapGVDVVDDWsgFGQKLTASGTTTFKDLEVDPRWIIprtdapt-------------lvwt 228 Corynebacterium ...
NP_251014   181 dd------tgADVIAAIRTdqpGVRQSDDWdgFGQRTTGSGTSLFEDAEVEEENLIdfasrfk-------------yqta 241 Pseudomonas aeru...
Feature 1                                                                                       
BAC20182    251 ivQLVFATVYLGIARGALETAREYTRTQARPWtpagvt---------qavedPYTIRSYGEFGIELQAGDAAAREAAQLL 321 Bacillus subtilis
XP_322874   272 tiQLVFTNFYLGIALAALDRAAAYTRKSTRPWpylsggeretvapaekatdeFYILSTYGTHHAHLLAATALVDQANERL 351 Neurospora crassa
ZP_00032686 236 isQLVLTNLFVGIAQGALDEARAYVTQHGKAWiysgvd---------katddPYLIQRFGEMRLQAVSAEALATRAAWLL 306 Burkholderia fun...
ZP_00057322 250 aiQLVFTNLYLGIAQGALETAAAYTRSTTRPWpyggdnk-------esavdeWYILEAYGDLQSKLWSVEALTDQVGTQL 322 Thermobifida fusca
BAC66052    231 iaQLHFANLFLGIAEGAFEEARQYTLKESRPWfrssaa---------ssaedPYVLRHYGEFWVGLESVRLLIERAARQL 301 Pseudomonas putida
NP_105924   254 ifQIIQVAVDTGIAQAAIDETVHFVRTRSRAWidsgvd---------nawddPYTIQAVGDLTLRLHAAQALLEKAGLAI 324 Mesorhizobium loti
ZP_00024019 289 vfQLFLAATEAGIARNALNDAVWFARNKARPIkhssae---------rsvddPYVQETIGQISAEVFAAEAATLRAADTI 359 Ralstonia metall...
ZP_00032429 245 yyQALHIANLAGISRAALRDAVAFTQARTRTFgvpgas---------sprdnPLVHRVVGRLASLAYSTQSISTSLARAI 315 Burkholderia fun...
NP_600240   229 ylQLSLLTVLVGSAAAAVDEVVARAQSSTRNAwnpgv----------errsdPAATIAIGDARSRVTVIRGALLDATRHV 298 Corynebacterium ...
NP_251014   242 fyQLVLLAVLAGTGRAALRDVAAEVRGRTRIYshgnap---------rvsqdPQVQQVVGRIAARVYAAEAATLCAAEAA 312 Pseudomonas aeru...
Feature 1                                                                                       
BAC20182    322 QTAWdkgda---------ltpqeRGELAVQVAGVKAIATKAGLDVTSRIFEVIGARGTHPNYGFDRFWRNIRtHTLHDPV 392 Bacillus subtilis
XP_322874   352 SGLFaayagnhtrdnrgevtalqRGEISELIAAAKIVVTDVGLKVTTDVFEVTGSRATASKVGLDRFWRDLRtHTLHDPI 431 Neurospora crassa
ZP_00032686 307 DDAWqrgaa---------lspetRAQVALATSEAKIVAHRAALDVSEQLFDACGARATHAPLALDRFWRNARvHTLHDPL 377 Burkholderia fun...
ZP_00057322 323 SQILhgdrea--------vtarqRGEIAVRVAAAKQRAIDVGLEVTSRIFEVTGARATASSVGLDRFWRNLRtHSLHDPV 394 Thermobifida fusca
BAC66052    302 DAAWakeha---------ltaqeRGDLALAIGTAKVAASRHGLDICNRLFEVTGARATHASLRFDRHWRNLRtQTLHDPV 372 Pseudomonas putida
NP_105924   325 DKAVaept------------aetVAHAQIVTAEAKILSTEIAIAATNKLFELAGTRSTLAEHNLDRHWRNARtHTLHDPV 392 Mesorhizobium loti
ZP_00024019 360 DAAWadnl-----------snasLTQASIDVAQAQVFTVAAALKASELALDVGGASSCDRQYNLDRHWRNARtVANHNPR 428 Ralstonia metall...
ZP_00032429 316 DEVSvareeg-------rtgeqtYIHLDIQTFQAQQIVIEQTLQAATLLFEVGGASATSETHRFDRYWRNARvLASHNPA 388 Burkholderia fun...
NP_600240   299 SNAAtivt------------peaFNEADAIVAALWPIVSGQALVVTSNVFDAVGASAVLGEHSIDRHWRNVRtVSSNNPV 366 Corynebacterium ...
NP_251014   313 QRAYlarfvgd-----pqaekeaNIAAEIESAKAQAIVAELVLQATSELFDASGASAVGRGKQLDRHWRNARtAASHNPL 387 Pseudomonas aeru...
Feature 1                        
BAC20182    393 SYKIAEVGNYVLNQRYP 409 Bacillus subtilis
XP_322874   432 AYKRREVGRWMLLGEIP 448 Neurospora crassa
ZP_00032686 378 DYRVRDVGRYALTGTLP 394 Burkholderia fungorum
ZP_00057322 395 AYKRREVGRYTLLNEIP 411 Thermobifida fusca
BAC66052    373 DYRIHELGEWALNDKRP 389 Pseudomonas putida
NP_105924   393 RWKYSILGKYFLNGENP 409 Mesorhizobium loti
ZP_00024019 429 QWKAAAVGAWLLKDEPP 445 Ralstonia metallidurans
ZP_00032429 389 IIREAAIGDFYLNGSAH 405 Burkholderia fungorum
NP_600240   367 FLAKNAVGEYALNGTPV 383 Corynebacterium glutamicum ATCC 13032
NP_251014   388 IYKQRIVGDWEINGSEP 404 Pseudomonas aeruginosa PAO1

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