Conserved Protein Domain Family
LCAD

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cd01160: LCAD 
Long chain acyl-CoA dehydrogenase
LCAD is an acyl-CoA dehydrogenases (ACAD), which is found in the mitochondria of eukaryotes and in some prokaryotes. It catalyzes the alpha, beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of LCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. LCAD acts as a homodimer.
Statistics
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PSSM-Id: 173849
View PSSM: cd01160
Aligned: 5 rows
Threshold Bit Score: 604.108
Threshold Setting Gi: 27376092
Created: 26-Mar-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:FAD binding site [chemical binding site]
Evidence:
  • Comment:based on similarity to other acyl-CoA dehydrogenases

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                       
ZP_00031355  18 EEHSMLRDVIRRFIAKEVLPFADQWEINGyvpRELLRKMGEQGFLgirqSEAFGGAam-nVLGTVVLAEELGRstFGGFA 96  Burkholderia fun...
NP_767621    39 AEHDAFRDVMRRFVEKEISPFAHEWDEAGefpRALYRKAAEIGLLglgfPEEYGGIaa-dQFMKIVASQELAQagAGGVS 117 Bradyrhizobium j...
AAH44447     67 EEHDLFRQNVRRFFQEEVAPYHAQWEKAGevsREVWEKAGEHGLLgvytPEEHGGIgg-dLLSAAIVWEEQMY--SNCSG 143 zebrafish
P28330       55 PEHDIFRKSVRKFFQEEVIPHHSEWEKAGevsREVWEKAGKQGLLgvniAEHLGGIgg-dLYSAAIVWEEQAY--SNCSG 131 human
NP_630859    10 PDHEAFRDTVRAFLAKEVAPHHQRWERNGvvdREVWYSAGRQGLLgpavDQEYGGGgsddFRYSAVLIEEFAR--AGASG 87  Streptomyces coe...
Feature 1                                             # ##    ##                       # #      
ZP_00031355  97 ITVLVHTdMASPHLQHAGNPAQLERLMPDLVAGrKIAAVAMTEAGAGSDLASMRTTARLDGDHYVLNGAKMFITNGvHGD 176 Burkholderia fun...
NP_767621   118 ASLMSHT-IGSPPIARAARPEVKARVLPQVLAGeKISALAITEPGGGSDVANLRTRARRDGDHYVVSGEKTFITSGmRAD 196 Bradyrhizobium j...
AAH44447    144 PGFSLHSeIVMPYISHYGSKAQIERYIPQMAAGkCIGAIAMTEPGAGSDLQGAKTFAKKDGTDWILNGSKVFITNGwMSD 223 zebrafish
P28330      132 PGFSIHSgIVMSYITNHGSEEQIKHFIPQMTAGkCIGAIAMTEPGAGSDLQGIKTNAKKDGSDWILNGSKVFISNGsLSD 211 human
NP_630859    88 LALSLHNdIVGPYLTRLATEEQKRRWLPGFVSGdIVTAIAMTEPGAGSDLQGIRTTATDRGDHYLLNGSKTFISNGiLAD 167 Streptomyces coe...
Feature 1                                                                                       
ZP_00031355 177 IYFVAAKTggpg-rshGGISMFIVEKgmpGFSVARpLSKQGWLSSDTAELVFDECRVPVqnLLGEENKGFYSLVRNLQNE 255 Burkholderia fun...
NP_767621   197 YLTVAVRTgge---gaGGVSLLLIAGdtpGLSRTK-LKKMGWWASDTATLHFDDCRVPAenLIGEEGQGFKIIMQNFNSE 272 Bradyrhizobium j...
AAH44447    224 VVIVVAVTdreaktaaHGISLFLVDRgtkGYQKGRkLEKLGLKAQDTAELFFEDVRLPAeaLLGQVNKGFYYLMNELPQE 303 zebrafish
P28330      212 VVIVVAVTnheapspaHGISLFLVENgmkGFIKGRkLHKMGLKAQDTAELFFEDIRLPAsaLLGEENKGFYYIMKELPQE 291 human
NP_630859   168 LVVVVARTtpe--ggsAGQSLLVVERgadGFERGRnLAKIGQQAQDTAELFFNDVHVPKenLLGEENRAFTYLMGNLAQE 245 Streptomyces coe...
Feature 1                                                                                       
ZP_00031355 256 RITLGAQALGEASRAIEITLDYVTQRTAFGQTLWEKQAIRQKMAMLLAKVEAARQLLYNTAWRDAQgqtvVAEVSMIKAL 335 Burkholderia fun...
NP_767621   273 RMGMAAGCTAFARVCLDEAIAYAKERKTFGKPLAQHQVIRHKIVDMAQKVAASQAMLEMLAWRLEQgespVAEICMMKNQ 352 Bradyrhizobium j...
AAH44447    304 RLLIAVMGLASCEFMFEESRNYVMQRKAFGRTIADLQVVQHKLAELKTEICVGRAFIDSCLQLHSEkkldSSTASMAKYW 383 zebrafish
P28330      292 RLLIADVAISATEFMFEETRNYVKQRKAFGKTVAHLQTVQHQLAELKTHICVTRAFVDNCLQLHEAkrldSATACMAKYW 371 human
NP_630859   246 RLAIAVGAAAATEEILDITTRYVKEREAFGRPLAKLQHVRFEIAEMATEAAVTRTFLDRCVTEHVAgrldPVHASMAKWW 325 Streptomyces coe...
Feature 1                                         #      # #            
ZP_00031355 336 CGELVNEVMYACQQFHGGFGYMReapIERMVRDARVQSIGGGATEVMLEEVAKRMV 391 Burkholderia fungorum
NP_767621   353 ATQTMAFCASEAVQIFGGAGFMRgikAERIYREVKVNAIGGGTEEIMKDLASRQMG 408 Bradyrhizobium japonicum USDA 110
AAH44447    384 ATDLQNRVATQCLQLHGGWGYMWeypIAKAFADARVQPIYGGTNEIMKELISRNIV 439 zebrafish
P28330      372 ASELQNSVAYDCVQLHGGWGYMWeypIAKAYVDARVQPIYGGTNEIMKELIAREIV 427 human
NP_630859   326 ATELQKRVVDRCLQLHGGYGYMSeyrVARAFLDGRIQTIYGGTTEIMKEIIGRSLL 381 Streptomyces coelicolor A3(2)

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