Conserved Protein Domain Family
NcnH

?
cd01159: NcnH 
Naphthocyclinone hydroxylase
Naphthocyclinone is an aromatic polyketide and an antibiotic, which is active against Gram-positive bacteria. Polyketides are secondary metabolites, which have important biological functions such as antitumor, immunosupressive or antibiotic activities. NcnH is a hydroxylase involved in the biosynthesis of naphthocyclinone and possibly other polyketides.
Statistics
?
PSSM-Id: 173848
View PSSM: cd01159
Aligned: 12 rows
Threshold Bit Score: 374.378
Threshold Setting Gi: 4240433
Created: 26-Mar-2010
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Conserved Features/SitesClick to see Conserved Features Help
 
Flavin binding
Feature 1:Flavin binding site [chemical binding site]
Evidence:
  • Comment:based on similarity to acyl-CoA dehydrogenases

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                       
NP_355476    48 SRVAGIADLFRSSARQTEEARRVPaSHIEALRGIGYFDIVkPRAFNGkggdfaELVEANIELsaaCASTGWVAGlLSAHQ 127 Agrobacterium tu...
NP_857240    14 AAIDDLLPEIRDRAQATEDLRRLPdETVKALDDVGFFTLLqPQQWGGlqcdpaLFFEATRRLasvCGSTGWVSSiVGVHN 93  Mycobacterium bo...
AAG44124     36 QRARDLAELAGKHAGDADRERRLHpDVVRAVAEAGFGRHFvPVRWGGadgtfaDLLAAVARVgegCTSAAWVAAlAATVP 115 Streptomyces arenae
AAD13564     25 SAAEDVAALAGDQAARADETRRLDpDVMKVVLGRRFARHFvPVEHGGaagtftELTEALVTVgtaCAASSWSASiVAGVG 104 Streptomyces cya...
NP_822484    20 ERVRALRPLIRENALRAERERRVPdEVVEALTGTGIHRMNvPRRYGGhqtplrTQVDAFAEIaaeCASTAWMTLsQAGVS 99  Streptomyces ave...
NP_934384    10 EKLNAILPTIAKNAQQAEQDRTPPeENIRLLREIGFFRAFqPKAYGGleislpEFTDCVAALagaCGGTAWGASlLATHS 89  Vibrio vulnificu...
AAA85688     19 AKAEEIGRIAEEEAGEADRNACFSdRVARAIKEAGFHKLMrPKQYGGlqvdlrTYGEIVRTVarySVAAGWLTYfYSMHE 98  Geobacillus stea...
ZP_00095865  52 ARAAAMVPTLRERAPEAERECRIPaQTIRDFQDAGFFRILqPARYGGyemdpqAFYAVQMKVaegCMSSAWVLGvVAVHN 131 Novosphingobium ...
NP_772255    23 VGIRELAPEIKARAAEIEAARRIPpDLVERLRSIGLFRMFvPHSHGGlelefpAGLEVIKTLarlDGSIGWIAAvAGVSS 102 Bradyrhizobium j...
CAA06672     23 AEAVKIAPVVAEAAPEALELRRAPdRSVEALINGGLTVMSlPVEHGGwraptaVQAEVMATLteaDGSFAWVTSiYNAVG 102 Rhodococcus opacus
NP_521780    12 QVVEDLAPKLAAKSVFIEQARHLPqEIADELAARGLYRMLtPRSFGGhevdimTFASVIERLaraDASAAWCTFiSCTSA 91  Ralstonia solana...
NP_768703    30 DNLSPLLVEIRARRNEFGPAQEIPkEIIDGFRRIGIYRAMvAKRFGGeertpaEFCRQIERIseaDGSAGWVAS-FGDGA 108 Bradyrhizobium j...
Feature 1                                                            # #                        
NP_355476   128 WLLAMfPEEAQADVWGEnpd--allCGSYAPvKMAEAAd----GGYRLSGKWAFASGCeNAQWSLCAAILppkg------ 195 Agrobacterium tu...
NP_857240    94 WHLALfDQRAQEEVWGEdps--triSSSYAPmGAGVVVd----GGYLVNGSWNWSSGCdHASWTFVGGPVikdg------ 161 Mycobacterium bo...
AAG44124    116 RMAAHlPRQGQAEVWSDgpd--tllVGALMPlGRAERAa----GGWRLTGTWSYVSGVdFSDWALVCARTaed------- 182 Streptomyces arenae
AAD13564    105 RMAGFlPAEGRAEVWKDgpd--avvVGSLAPlGRAKAVp----GGWRLSGTWPSISVVdFSDWALVRAVVads------- 171 Streptomyces cya...
NP_822484   100 YIAALfPDEAQDEFFTGpggpdvriGGTLIPgATAVPYg----GGYRVSGTSAFATGChHADWHLLTTAVaaadgq---l 172 Streptomyces ave...
NP_934384    90 HQMAMfSKQAQEEFWGSnpe--ataSSSIAPfGKIEEAe----GGVIINGDMRWSSGCdHADWAILGFNRfdda------ 157 Vibrio vulnificu...
AAA85688     99 VWAAYlPPKGREEIFGQgg----llADVVAPvGRVEKDg----DGYRLYGQWNFCSGVlHSDWIGLGAMMelpd------ 164 Geobacillus stea...
ZP_00095865 132 WQLALfDPRAQEDVWGDdpa--tliSSSYMPkGKVVPVd----GGYRVSGHWGFSSGIdHCEWAFLGGQMtdpe------ 199 Novosphingobium ...
NP_772255   103 LFVAAsPPELYKRVYQDgpd--taiCGSSQPgGTAERVa----DGYRVKGRWPFASGCmHADWIGGICIVtengkpv-pg 175 Bradyrhizobium j...
CAA06672    103 HMVCAfGDQALEEFLGSeip---rsAGVFAVtGRSAAVd----GGYRVSGKWGFSSGQhHAGWIIVPGIPee-------- 167 Rhodococcus opacus
NP_521780    92 LVGAYlPTDEAARLFADpav---klAGVYAPgGRATRTerngvPGFLVSGHWNWGSGSrNANYIVGGCFIidddgkpelt 168 Ralstonia solana...
NP_768703   109 RYLAAlPDDTLRKVYANgpd--vvlAGALFPlQPARRCa----GGFVVNGVWPFASGSpGADLIGVGIKLeddp------ 176 Bradyrhizobium j...
Feature 1                                                                                       
NP_355476   196 --egkPVPAFLLVPasQYVVEDTWhvvGLAGTGSKTLVLDDVFVPEHRVLtfpdatsgctpggryya-eeslfnmplltg 272 Agrobacterium tu...
NP_857240   162 --rpvDFGSFLIPRs-EYEIKDVWyvvGLRGTGSNTLVVKDVFVPRHRFLsykamndhtagglatn--sapvykmpwgtm 236 Mycobacterium bo...
AAG44124    183 --gveVPRYFALPRe-AYAIRDTWftvGMRGTGSNTLSVDDVYVPDHRVCtraavldgdcpdapa-----dctrvplkav 254 Streptomyces arenae
AAD13564    172 --egqALRVFVVPRa-GYEIQDTWsnvGMRATGSNTLVVDDVFVPDARTFegddlfqgrprsssa-----achsvplqav 243 Streptomyces cya...
NP_822484   173 ppgppEIRWAAVPMa-ELEILDDWhvtGLAGSGSNTVVARDVFVPAHRMLavgpmlagrfpskana--ddpfyrmpvlll 249 Streptomyces ave...
NP_934384   158 --gnkIYCFGVVPRh-EYKIVDDWyaaGMKSSGTKTLVLDNVFIPEHRIEtakgmmeghsagfdlyp-dsdifytpyrpy 233 Vibrio vulnificu...
AAA85688    165 -gnspEYCLLVLPKs-DVQIVENWdtmGLRASGSNGVLVEGAYVPLHRIFpagrvmahgkpvggdydendpvyrmpfmpl 242 Geobacillus stea...
ZP_00095865 200 -tgrpDFVTFLIPRk-DFTVLPIWdtvGLGATGSHDVVVEDAFVPAYRMHrskdgfavtspglktn--daplfrlpfgqv 275 Novosphingobium ...
NP_772255   176 pqgkpLLRAVMLPAr-DWEIEDTWhvaGLEGTGSHHVTLRETLVPEANFFdldvaprqsgpl-----------yralrql 243 Bradyrhizobium j...
CAA06672    168 ---ggAPIAFLVPKa-EFEVKDDWfvtGFIGTGSNTVVLDDVFVPEYRAIpfmdivtgnyrtas------lagdtyynqp 237 Rhodococcus opacus
NP_521780   169 pagkpNVQSMVFSAe-QVTIADTWhsvGLCGTGSNEFSVEGVFVPTSRTAslvvdtplprpl----------yrfpvfgv 237 Ralstonia solana...
NP_768703   177 --agdLPRVAVIPAe-KVTIRPNWdviGLRGTGSHDVVVSDVIVPEQWTLirggpatldgpi----------yrypsvaf 243 Bradyrhizobium j...
Feature 1                                                                                       
NP_355476   273 ipscLAAAGVGAAKGALAAYVDHVGGRVTRGavaggn-nrmaefPTIQLRVAEAAASVDAACEILLRDVSRAQAlaqari 351 Agrobacterium tu...
NP_857240   237 hpttISAPIVGMAYGAYAAHVEHQGKRVRAAfagek----akddPFAKVRIAEAASDIDAAWRQLIGNVSDEYAllaagk 312 Mycobacterium bo...
AAG44124    255 nglsFAAPVLGAAKGLLAEWTRWAAPRITGTgdgdp---rlaenALRHGVLARAAGEVDGAELLLDRTARAADTgald-- 329 Streptomyces arenae
AAD13564    244 nglsFAAPALGAARGALAVWSDYATAKFRSAprepgg--pgisrGFYATTLARAAGEIDMAYLLLDRAGRVADRgagv-- 319 Streptomyces cya...
NP_822484   250 fcawSAPVALGLARAAVAEFTERIHRRGITYtfher----qneaTVTHLQVAEAEMRVGGAELHLARLTAEIEAkarddl 325 Streptomyces ave...
NP_934384   234 facgFAAISLGIAERMLVVFAEKQKNRVRAYtgan-----vgvaTPALMRLAESTHQVAAARALLEKTWNDHKEhgerke 308 Vibrio vulnificu...
AAA85688    243 fllgFPLVSLGGDERLVSLFQERTEKRIRVFkggak----ekdsAASQRLLAEMKTELNAMEGIVEQYIRQLEAcqkegk 318 Geobacillus stea...
ZP_00095865 276 fvraVSSSSIGALQGALDLFREAGARRVSHNdass-----aaqdPATLELIAETASAIDEMKATLNRNFDHLMDvaragg 350 Novosphingobium ...
NP_772255   244 lplvHGAFVVGMAESTVDELLALANTGRQQLyaavp----mresEIFQYELGRISAELGAAQAFHEVQAASHWRhalagt 319 Bradyrhizobium j...
CAA06672    238 fvpfMCAMSVGPAIGLGRAALRAFEERVGSRgitytnyarqadaPITFHQLAEARMKLDQAKFHADRITTAVDEhaasga 317 Rhodococcus opacus
NP_521780   238 lglsIAAVALGIAHRAIESLIDLSKQKTPQGstrp-----laerSGTQLAIAYCSARLRAARAFLHEVLEDTWAvskgsd 312 Ralstonia solana...
NP_768703   244 aaqaHAVVGIGIARAAIDEVIAMAGSRASITgapv-----maerGYVQLEIAKAESMLRSARSFFYEATEELWKqaltgg 318 Bradyrhizobium j...
Feature 1                                                                  #       # #        
NP_355476   352 egraeftvddRLLSRRGQSFAVSLSLRAVQALNDSTGGVGLDLANPVQRAWRDANavgrHISMNwDAVGTMIGQSMLG 429 Agrobacterium tume...
NP_857240   313 ----eipfelRARARRDQVRATGRSIASIDRLFEASGATALSNEAPIQRFWRDAHagrvHAANDpERAYVIFGNHEFG 386 Mycobacterium bovi...
AAG44124    330 -------pllTARGGRDCALAAELLLTAADRLFRAAGTSAQVEGSPFERGWRDVSaavsHLVLRfEPAATAYAQAVLT 400 Streptomyces arenae
AAD13564    320 ------tpleAPRNTRDCALAVETSVTAVNRIFAAAGTSGHSTASSLQRFWRDANaaatHIGLQfEPAAMAYASAVSA 391 Streptomyces cyano...
NP_822484   326 ----pytpleRARIRAESGYVTRICREAVDLLAAASGASSLHQEVPMQRITRDIHalclHSFVNpTTNMEIYGRVLSG 399 Streptomyces averm...
NP_934384   309 ----ypdaetLTYWRTNQAYAVKMCIAAVDRLFEAMGGMAWFSDNEGQRLFRDSHmtgaHAYTDyDVCAQILGRQLMG 382 Vibrio vulnificus ...
AAA85688    319 t---vmndmeREQLFAWRGYVAKASANIAVRTLLTLGGNSIFKGDPVELFTRDLLavaaHPNSLwEDAMAAYGRTIFG 393 Geobacillus stearo...
ZP_00095865 351 ----qadvetRLTYRYQSAEVSGRCAALVSRIFHASGAEGIFRNRPLSRIFCDIHagrtHVANNpAKVGRNFGGVLLG 424 Novosphingobium ar...
NP_772255   320 ----lndedlVVEGTRSATWLATTCVGIADACFSLAGSSAVYDSSPLQRRLRDLHvaaqHAHAQ-QRQYVDVGKLALR 392 Bradyrhizobium jap...
CAA06672    318 ----awdvveRVRCRADIAWAIKLTREACEIVEHGSGANALRAQDKLGSILRDIRtmsvHSFLLhSTNAELYGRILAG 391 Rhodococcus opacus
NP_521780   313 ----piavshRRDIRLAATFATTESASVVDRMHRLAGGSAVYQASPIQRCLRDIHvatqHIMVS-ESTYELAGRLLLD 385 Ralstonia solanace...
NP_768703   319 -----vnlstTMQVRLAATNAARQGAEVCRISSGLAGTEALYTSSNLARAMCDSFvvaqHAALN-EGTLQSAGLALLG 390 Bradyrhizobium jap...

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap