Conserved Protein Domain Family
ACAD_FadE2

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cd01155: ACAD_FadE2 
Acyl-CoA dehydrogenases similar to fadE2
FadE2-like Acyl-CoA dehydrogenase (ACAD). Acyl-CoA dehydrogenases (ACAD) catalyze the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACAD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. ACAD's are generally homotetramers and have an active site glutamate at a conserved position.
Statistics
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PSSM-Id: 173844
View PSSM: cd01155
Aligned: 10 rows
Threshold Bit Score: 721.869
Threshold Setting Gi: 13879647
Created: 26-Mar-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:FAD binding site [chemical binding site]
Evidence:
  • Comment:based on similarity to other acyl-CoA dehydrogenases

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     
NP_104278   7 ERLKPIHARVAAMVRDEIMPLDKEFLGEvgkagdrwvysprqseilEGLKKTARERGLWNFWLTGSERGYgl-------- 78   Mesorhizobium loti
XP_236582 376 RRGQEVLTRVKQFMKQHVFPAEKEVAEYyaqngnsae-kwehplviEKLKEMAKAEGLWNLFLPAVSGLS---------- 444  Norway rat
AAH45470  364 SKGQAVLQHVKRFMRKHVLPAEQEVKEYyathkdtae-rwctppviEELKAKARAVGLWNLFLPEVSDLS---------- 432  zebrafish
NP_625964   7 AHTEELRARLLAFMDEYVYPAEQVAHEQrarlasp----wdtpqvvEDLKAEARRQGLWNLFLPDAEHGAgl-------- 74   Streptomyces coel...
XP_326674  15 ERAKKTLDVVARFVEEDCIPADTVYEAQigvgdarw---eahpqilEDLKAKAKSLGLWNMFLPKGHYKEspg------- 84   Neurospora crassa
AAM14036  404 RKVLELRQKLIKFMETHIYPMENEFSKLaqsdmrw-----tvhpqeEKLKEMAKREGLWNLFVPVDSAARarrelaaten 478  thale cress
D89057    573 LKAQKYYEIVREIIQNDVIPLEQELLEYyeegphrw---tiphpkiEKLKEKSKSLGAWNLFISEHIDPEqkyg------ 643  Caenorhabditis el...
AAG05938    7 PKVQELRERVSAFMEAHVYPAEAVFERQvaegdrw-----qptaimEELKAKAKAEGLWNLFLPESEYGAgl-------- 73   Pseudomonas aerug...
AAK44387    7 AKAIDYRTRLSDFMTEHVFGAEADYDDYrraagpad---htappiiEELKTKAKDRGLWNLFLSAESGLT---------- 73   Mycobacterium tub...
NP_115545 377 RKGQEVLIKVKHFMKQHILPAEKEVTEFyvqnensvd-kwgkplviDKLKEMAKVEGLWNLFLPAVSGLS---------- 445  human
Feature 1                                                                                     
NP_104278  79 -----------------sTVEYAYLAEEMGKA-HLGAETFNCSAPDTGNMEVLERYGSADHKKEWLEPLLDGKIRSAYLM 140  Mesorhizobium loti
XP_236582 445 ------------------QVDYALIAEETGKC-FFAPDVFNCQAPDTGNMEVLHLYGSEQQKQQWLEPLLRGDITSVFCM 505  Norway rat
AAH45470  433 ------------------QLDYAYIAEETGHC-YYAPEVFNCQAPDTGNMEVLHLFGTEEQKRMWLEPLLRGDIRSCFCM 493  zebrafish
NP_625964  75 -----------------tNLQYAPLAEITGRSpQLAPTATNCAAPDTGNMEVLAQFADEAQRKQWLEPLLAGEIRSAFAM 137  Streptomyces coel...
XP_326674  85 ----------------ftNLEYGLMAEWLGKS-RVASEAVNCSAPDTGNMEVLAKYGNEEQKAKWLKPLMDGKIRSAFLM 147  Neurospora crassa
AAM14036  479 khnlsgksfdqlfgegltNLEYGYLCEIMGRS-VWAPQVFNCGAPDTGNMEVILRYGNKEQISEWLIPLLEGRIRSGFAM 557  thale cress
D89057    644 --------------kgltNVEYAHICELMGRS-IFAPEVFNCQAPDTGNMEVLIKYGSEEQKSKWLTPLLNGEIKSCFAM 708  Caenorhabditis el...
AAG05938   74 -----------------aNHEYAPLAEIMGRS-LIGPEPFNCAAPDTGNMEVLVRYGSEEQKRTWLEPLLSGEIRSAFAM 135  Pseudomonas aerug...
AAK44387   74 ------------------NLEYAPLAEMTGWSmEIAPEALNCAAPDTGNMEILHMFGTEQQRAQWLRPLLDGKIRSAFSM 135  Mycobacterium tub...
NP_115545 446 ------------------HVDYALIAEETGKC-FFAPDVFNCQAPDTGNMEVLHLYGSEEQKKQWLEPLLQGNITSCFCM 506  human
Feature 1     # #      ##                                # #                                  
NP_104278 141 TEPdVASSDATNIGMRCERQGDDYVLNGEKWWASGAgdPRCAIYIVMVRTggdg--epqHRRHSMILVPSDTkGVTKLRa 218  Mesorhizobium loti
XP_236582 506 TEPnVSSSDATNMECSIQRDGGSYIVHGKKWWSSGAgnPKCKIAVVLGRTesps--vsrHKVHSMILVPMDTpGVELIRp 583  Norway rat
AAH45470  494 TEPdVASSDATNMECTMHRDKDDFIINGKKWWSSGAgnPKCEIAIVMCRSkamdsnnkrHGVHTMILVPMSTpGVKKIRp 573  zebrafish
NP_625964 138 TEPeVASSDATNITTHIERDGDEYVVTGRKWYISGAmnPDCKIFIVMGKTdpdg--ediRRQQSMVLVRRDTpGVTVDRa 215  Streptomyces coel...
XP_326674 148 TEPqVASSDARNIEMKITKDGDHYVLNGQKWWSSGAgdPRCKVYIVMGKSdpnn--kdpYRQQSVIIVPSDTkGITIERm 225  Neurospora crassa
AAM14036  558 TEPqVASSDATNIECSIRRQGDSYVINGTKWWTSGAmdPRCRVLILMGKTdfn---apkHKQQSMILVDMRTpGISVKRp 634  thale cress
D89057    709 TEPdVASSDATNIQGSIVRVGNEYIINARKWFISNAshPKCRIAIFMGQVsgak--rsrNLQQSMILVPMQTeGVKIIRn 786  Caenorhabditis el...
AAG05938  136 TEPgVASSDATNMEARAERQGDDWVINGRKWWTSGAcdPRCKILIFMGLTnpd---aprHQQHSMILVPVDTpGVKILRp 212  Pseudomonas aerug...
AAK44387  136 TEPaVASSDARNIETTISRDGADYVINGRKWWTSGAadPRCKILIVMGRTnpd---aaaHQQQSMVLVPIDTpGVTIVRs 212  Mycobacterium tub...
NP_115545 507 TEPdVASSDATNIECSIQRDEDSYVINGKKWWSSGAgnPKCKIAIVLGRTqnts--lsrHKQHSMILVPMNTpGVKIIRp 584  human
Feature 1                                                                                     
NP_104278 219 mqVYGDDDa-PHGHMHLRFDNVRVPAs-----------nLILGEGRGFEIAQGRLGPGRIHHCMRAIGQAEMALEMLCQR 286  Mesorhizobium loti
XP_236582 584 lsVFGYMDnvHGGHWEVHFNHVRVPAsnlilgafsysvcFLTGEGRGFEISQGRLGPGRIHHCMRSVGLAERILQIMCDR 663  Norway rat
AAH45470  574 ltVFGQDDaiHGGHFEIHFDNVRVPAs-----------nIILGEGRGFEIAQKRLGPGRLHHCMRAVGLAECALELLCHR 642  zebrafish
NP_625964 216 mqVFGYEDhyHGGHAEVTFDHARVPVs-----------nLIGEEGGGFAIAQARLGPGRIHHCMRLIGMAERAIELMCRR 284  Streptomyces coel...
XP_326674 226 lsVYGYDDa-PHGHGHITFYNVRVPAa-----------nLVLGEGRGFEIIQGRLGPGRIHHAMRTIGAAERALEWMLMR 293  Neurospora crassa
AAM14036  635 ltVFGFDDa-PHGHAEISFENVVVPAk-----------nILLGEGRGFEIAQGRLGPGRLHHCMRLIGAAERGMELMAQR 702  thale cress
D89057    787 thVFGSQDa-PGGHPEITFTNVRVPVg-----------nMLLGEGKGFEIAQGRLGPGRIHHAMRLIGHAERAIDVIKDR 854  Caenorhabditis el...
AAG05938  213 lpVFGYDDa-PHGHAEVLFENVRVPYe-----------nVILGEGRGFEIAQGRLGPGRIHHCMRSIGMAERALELMCKR 280  Pseudomonas aerug...
AAK44387  213 tpVFGWQD--RHGHCEIDYHNVRVPAt-----------nLLGEEGSGFAIAQARLGPGRIHHCMRALGAAERALALMVNR 279  Mycobacterium tub...
NP_115545 585 lsVFGYTDnfHGGHFEIHFNQVRVPAt-----------nLILGEGRGFEISQGRLGPGRIHHCMRTVGLAERALQIMCER 653  human
Feature 1                                                                                     
NP_104278 287 SVR--REAFGQKLAKLGANFDIIAECRMEIEMARLLCLKAAWMIDQgdaraaAPWISQIKVIAPRVALRITDEAVQMFGA 364  Mesorhizobium loti
XP_236582 664 AVQ--REAFGKKLYEHEVVAHWIAKSRIAIEEIRLLTLKAAHSIDTlgsaaaRKEIAMIKVAAPKAVCKIADRAIQVHGG 741  Norway rat
AAH45470  643 SAQ--RQTFGKRLYQHEVVAHWIAECRITIAQTRLLTLHAAHTLDTkgnkaaRKQIAMIKVAAGRMACKVVDCAIQVYGG 720  zebrafish
NP_625964 285 AVS--REAFGKALAQQGVVHNWIADARVTVEQLRLLVLKTAWLMDTvgnrgaHTEIQAIKIATPRAVVGIIDRAIQLHGA 362  Streptomyces coel...
XP_326674 294 INDpkKTPFGKQLREHGVILEWVAKSRIDIDAARLVVLNAAIKMDEqgpkaaLTEIAQAKVLVPQTALTVIDRAVQSFGG 373  Neurospora crassa
AAM14036  703 ALS--RKTFGKFIAQHGSFVSDLAKLRVELEGTRLLVLEAADHLDKfgnkkaRGILAMAKVAAPNMALKVLDTAIQVHGA 780  thale cress
D89057    855 LLT--RIAFGRKLVQFDSLRKELALSRCEVEQARLLVLKAAHMIDTvgpkeaKSEIAMIKVVAPNMAISILDRAMQQQGA 932  Caenorhabditis el...
AAG05938  281 AVS--RTAFGKPLARLGGNIDHIADSRMEINMARLLTLQAAYMMDTvgnkiaQSEIAQIKVVAPNVALKVIDRAIQMHGG 358  Pseudomonas aerug...
AAK44387  280 VRN--RVAFGRPLAEQGVVQQAIAQSRNEIDQARLLCEKAAWTIDQhgnkeaRHLVAMIKAVAPRVACDVIDRAIQVHGA 357  Mycobacterium tub...
NP_115545 654 ATQ--RIAFKKKLYAHEVVAHWIAESRIAIEKIRLLTLKAAHSMDTlgsagaKKEIAMIKVAAPRAVSKIVDWAIQVCGG 731  human
Feature 1                                            
NP_104278 365 QGISQdtPLARSWTHLRTLRLADGPDAVHRRQVARTELK 403  Mesorhizobium loti
XP_236582 742 AGVSQdyPLANMYAIIRTLRLADGPDEVHLSAIAKMELQ 780  Norway rat
AAH45470  721 AGVSDdfPLAEMYAYARTLRIADGPDEVHLSSIALQELR 759  zebrafish
NP_625964 363 GGVSQdfPLAELYAGARTLMIADGPDEVHQRSLARRELK 401  Streptomyces coelicolor A3(2)
XP_326674 374 AGVSQdtPLANMWAQIRTLRLADGPDEVHLQQMGRNENK 412  Neurospora crassa
AAM14036  781 AGVSSdtVLAHLWATARTLRIADGPDEVHLGTIGKLELQ 819  thale cress
D89057    933 RGLTPftPLASFYVWARSLRIADGPDAVHLETIAKIEMK 971  Caenorhabditis elegans
AAG05938  359 AGVSNdfPLAYWYAMQRTLRLADGPDEVHRAAIGKFELG 397  Pseudomonas aeruginosa PAO1
AAK44387  358 AGVSDdtPLARLYGWHRAMRIFDGPDEVHLRSIARAELS 396  Mycobacterium tuberculosis CDC1551
NP_115545 732 AGVSQdyPLANMYAITRVLRLADGPDEVHLSAIATMELR 770  human

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