Conserved Protein Domain Family
AidB

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cd01154: AidB 
Proteins involved in DNA damage response, similar to the AidB gene product.
AidB is one of several genes involved in the SOS adaptive response to DNA alkylation damage, whose expression is activated by the Ada protein. Its function has not been entirely elucidated; however, it is similar in sequence and function to acyl-CoA dehydrogenases. It has been proposed that aidB directly destroys DNA alkylating agents such as nitrosoguanidines (nitrosated amides) or their reaction intermediates.
Statistics
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PSSM-Id: 173843
View PSSM: cd01154
Aligned: 9 rows
Threshold Bit Score: 561.222
Threshold Setting Gi: 15610933
Created: 26-Mar-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:FAD binding site [chemical binding site]
Evidence:
  • Comment:based on similarity to acyl-CoA dehydrogenases

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     
NP_147195   8 YLVDKPLRDTLRYFTSKe------pDLAGLGEYv-gTELYEVAYRVDRlswPVHVMWSVRGERSDTVLVDPALRRAVDRl 80  Aeropyrum pernix
NP_343016  20 FNIDKPLQKILEYFDVKa-------DFSKLGEFa-gGELYEIAEHVDKrarPIHVMWSVNGERVDEVWIDPSLRAAIKRl 91  Sulfolobus solfata...
NP_394117   4 FSDDIVLQDVLNYLGYDid-----dKLQEMGRYv-sEEMIEDSIFIDHygePVLQMWGILDNRTDGIWISRTHQNMIDRl 77  Thermoplasma acido...
NP_102440  24 WRGDPLLIQLAERFSDPvr-----kDLDGLGRFvltQEAQELARLANVe-tPKLRTHDRQGRRIDLVEFHPAYHALMRRs 97  Mesorhizobium loti
NP_499329  46 YKDDPILDRTLRRLLPEseymrvaaDLSKFGDRi-tSEVEHLGRQAELe-qPRLEHQDAWGKRVDKLIVCNEWHKLKQIc 123 Caenorhabditis ele...
P33224     21 YLSDGALCEAVTREGAGwd----sdFLASIGQQlgtAESLELGRLANVn-pPELLRYDAQGRRLDDVRFHPAWHLLMQAl 95  Escherichia coli
NP_625405  43 ASDDTVLLEGLRREGAGwa----edGLRRLGRRagsAQAQDWGDLANRh-ePVLRTHDRYGNRVDEVEYHPSWHHLMRVa 117 Streptomyces coeli...
NP_891339  32 WRLDPSLRQLLALCADTeelrhftpHFDRLGELa-gNTLDELADAADKh-pPTLAPRDRHGRDVDRIDYHPAYREMERIa 109 Bordetella bronchi...
NP_218314  37 YLTDPTLQFIMAYYLRPdelafaepHLTRIGELt-gGPVTRWAEETDRn-pPRLERYDRWGHDISRVVLPESFIQSKRAv 114 Mycobacterium tube...
Feature 1                                                                                     
NP_147195  81 myeygvn--------rhpyvggSWHEHFAGINLVgdp---gvGCILTITMQTAYALWKYg-GEELKHYYRRLAgld---- 144 Aeropyrum pernix
NP_343016  92 ikdfdin--------kfpykeeNWHKHYASIYLVsdp---giACILTITNQTAYALYKYg-SEELKKYVPYLIgds---- 155 Sulfolobus solfata...
NP_394117  78 ldmgvv---------skiasenDLMYHFISGYLIsda---glFCTLTLTGQTAYGLRKYg-DARLQQFLNHYAns----- 139 Thermoplasma acido...
NP_102440  98 vanglhssv----wengdaeigRRHQVRAARFYLtaeletghLCPITMTSASLAALMAS--PKLFREWAPRVTtrkydqs 171 Mesorhizobium loti
NP_499329 124 aeegvisig----yedsvdpfvRRIHQVAKLFLFspsa-glvSCPMAMTDGAVKTLTSL--NLYGKHKLATEAvdrlrs- 195 Caenorhabditis ele...
P33224     96 ctnrvhnl------aweedarsGAFVARAARFMLhaqveagsLCPITMTFAATPLLLQMl-PAPFQDWTTPLLsdrydsh 168 Escherichia coli
NP_625405 118 vgeglag-------apwadgrpGAHVARTAGGLVwghteaghGCPTSMTYAAVPALRAQ--PELAEVYEPLLTsreyepg 188 Streptomyces coeli...
NP_891339 110 fsefgmaaighkpgvlgwpghaSPLVKYTLTYLFsqae-fglLCPVNGNDAAVGMIQRYa-DDTLKQRMTGMLsqdm--- 184 Bordetella bronchi...
NP_218314 115 iearqavr-----ddaaragvkPSLALFAADYLLnqad-igmACALATGGNMVRSLVTAyaPPDVREFVLGKLnsg---- 184 Mycobacterium tube...
Feature 1                  # ##    ##                          # #                            
NP_147195 145 ------rppMIGATWFTEIQGGSDLGANETVARKAg-DGVWLLTG-YKYFASGAgLADIALVTARPegap----agaKGL 212 Aeropyrum pernix
NP_343016 156 ------delLFGATWFTEIQGGSDLGSNLVEAEFN--GKYWLLKGnTKYFASGVgLADLALVSARPmgsk----sgaKGL 223 Sulfolobus solfata...
NP_394117 140 -------dhWLGATYYTEIQGGSDLGANQTTAVRS--GDKYILNGeNKYFASNAgLADGAIVTARMegar----pgaKGI 206 Thermoplasma acido...
NP_102440 172 qkppvektgLTLGMGMTEKQGGTDVRANVTRAERAg-SGFYRLTG-HKWFMSAP-MSDAFLVLAQAp----------EGL 238 Mesorhizobium loti
NP_499329 196 ---rdpskaWTSGQWMTEKKGGSDVAGGCDTYAVQidKDTYRLHG-YKWFSSAV-DADVALTLARIvdsdgnalegsRGL 270 Caenorhabditis ele...
P33224    169 llpggqkrgLLIGMGMTEKQGGSDVMSNTTRAERLe-DGSYRLVG-HKWFFSVP-QSDAHLVLAQTa----------GGL 235 Escherichia coli
NP_625405 189 lrtptdkrgLLAGMGMTEKQGGSDVRTNATTATATaePGVYTLRG-HKWFTSAP-MCDVFLVLAQAa----------GGL 256 Streptomyces coeli...
NP_891339 185 ------rtlLKIGHFMTERTGGSDLAGIGTHARFD--GSAWKIYG-EKWFCSAI-DADYVLVLARPegap----agtRGL 250 Bordetella bronchi...
NP_218314 185 ------ewdGEAAQLLTERAGGSDLGALETTATRS--GDVWLLNG-FKWFASNC-AGEAFVVLAKPegap----dstRGV 250 Mycobacterium tube...
Feature 1                                                                                     
NP_147195 213 SLFAVPRyrrGGGLN-YSVRRLKDKSGTIAVPTGEVELQDSEAYLIGd---------aDKGIYYTLEDLMISRIANSAGA 282 Aeropyrum pernix
NP_343016 224 SLFLVPKknnKGEKN-FLIRRLKRKSGTNSVPTGEVEFNSSEAYLIGe---------kEYGIYYITEDLMVSRLSNAVGA 293 Sulfolobus solfata...
NP_394117 207 SVFFVPTlrsDGTRN-YEIRRIKDKLGTIMVPTGEVVLKDSEGYLLGd---------eKNGIYIALEILEVSRIDDAIAA 276 Thermoplasma acido...
NP_102440 239 SCFLVPRvlgDGSGNgFRFQRLKDKLGNRSNASSEVEFVNAIGEMIGe---------pGAGVKTIMDMVTLTRLDCAVAS 309 Mesorhizobium loti
NP_499329 271 SLFLLKIrdeSGNLNgIQMVRLKNKLGTKQLPTAELLLDGAIAERIGd---------qGRGVAGISNMLNITRIHNAVAS 341 Caenorhabditis ele...
P33224    236 SCFFVPRflpDGQRNaIRLERLKDKLGNRSNASCEVEFQDAIGWLLGl---------eGEGIRLILKMGGMTRFDCALGS 306 Escherichia coli
NP_625405 257 SCFLVPRvlpDGTRNtFRVQRLKDKLGNRSNASSEPEFDGTVAWLVGp---------eGQGVKTIIEMVNCTRLDCVMAS 327 Streptomyces coeli...
NP_891339 251 GMFVVPRlleDGTRNrYRIARLKNKLGTRSMATGEVVFDGALAHAIGq---------gRDGIRYAVLPINASRLSHGVRA 321 Bordetella bronchi...
NP_218314 251 ATFLVLRtrrDGSRNgVRIRRLKDKLGTRSVASGEIEFVDAEAFLLSgepsadagpsdGKGLTRMMELTNRLRLGTASFA 330 Mycobacterium tube...
Feature 1                                                                                     
NP_147195 283 VGIARKAYLEAYNYAKHRRAFGKRIIEHPLVRRDLLEMEVLIEESLALTHKAVDLFEKstgdrppy-smtyhyaRLMTHI 361 Aeropyrum pernix
NP_343016 294 LGIARKSFLESYYYSQSRKAFGKALIEHPLIQKDLLEMELMIEGGMVVTFKAIDQFQKswkamppfyneqyhyaRLLTHI 373 Sulfolobus solfata...
NP_394117 277 MGIARKALWEAYFYANKRTAFGKPIIDHPLMLRDLAEMESEVEASTVLSMIAADMFNKashlkppy-ddqyhmaRAFTHM 355 Thermoplasma acido...
NP_102440 310 SAIMRAGLAEAVHHARHRQVFGSTLIEQPLMQRVLADMALDVAAATALSFRLARSFDEaasdrg-----eaafaRAMTPV 384 Mesorhizobium loti
NP_499329 342 LGYMRRIISLARDYSTKRVVFGQTQSKWPLHTTTLAKMEVDTRGSMLLLFEAARLLGLseagkss--dveammlRLITPV 419 Caenorhabditis ele...
P33224    307 HAMMRRAFSLAIYHAHQRHVFGNPLIQQPLMRHVLSRMALQLEGQTALLFRLARAWDRradak------ealwaRLFTPA 380 Escherichia coli
NP_625405 328 ATLMRKTLVEAGHHVRHRTAFGARLVDQPLMRNVLADLALESEAATALTLRLAGAADRavrgde----geaafrRIATAV 403 Streptomyces coeli...
NP_891339 322 AGMMRRCLNESLHFARRRAAFGKPVIAHPLMKRSLLKIMVPTEQALSACMFVASTMHRagaddp----rdrkivRLATAL 397 Bordetella bronchi...
NP_218314 331 LGNARRALVESLCYAGQRRAFGGALIDKPLMRRKLAEMVVDVEAALAMVFDGFGAANHrqpr--------clpqRIAVPV 402 Mycobacterium tube...
Feature 1                                            #      # #            
NP_147195 362 AKNMTAQAAARVTMLAMELFGGIGFLREyaVERWHREALITPIWEGTSNIQALDMLEAMWK 422 Aeropyrum pernix
NP_343016 374 SKHITAEIASQVSRMAMEIHGGIGFLEEfpIERLHREALITPIWEGTGNIQALEMLEAMVK 434 Sulfolobus solfataricus
NP_394117 356 AKNIASWSSDYVTRYTMEVFGGKGFLKEfpVEKFHRDSIVTSLWEGTSNIQALDFLEIVQK 416 Thermoplasma acidophilum
NP_102440 385 VKYWVCKIAPPLLYEAMECLGGNGYVEEapLARYYREAPVNAIWEGSGNVMALDVLRVLGR 445 Mesorhizobium loti
NP_499329 420 LKLYAGKQAVPMVSEGIECFGGQGYMEDtgLPTLLRDAQVTPIWEGTTNVLSLDVLRVFSG 480 Caenorhabditis elegans
P33224    381 AKFVICKRGMPFVAEAMEVLGGIGYCEEseLPRLYREMPVNSIWEGSGNIMCLDVLRVLNK 441 Escherichia coli
NP_625405 404 GKYWVTKRGPAFTAEALECLGGNGYVEEsgMPRHYREAPLLSIWEGSGNVNALDVLRALGR 464 Streptomyces coelicolor A3(2)
NP_891339 398 LKFRACRDNATVATAAMEVRGGSGYIEEwiNARLVRDAQTGLLWEGTSNINALDIVTRAVA 458 Bordetella bronchiseptica
NP_218314 403 TKLKTCRLGITVASDAIEIHGGNGYIETwpVARLLRDAQVNTIWEGPDNILCLDVRRGIEQ 463 Mycobacterium tuberculosis H37Rv

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