Conserved Protein Domain Family
ACAD_fadE5

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cd01153: ACAD_fadE5 
Putative acyl-CoA dehydrogenases similar to fadE5
Putative acyl-CoA dehydrogenase (ACAD). Mitochondrial acyl-CoA dehydrogenases (ACAD) catalyze the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. The mitochondrial ACD's are generally homotetramers and have an active site glutamate at a conserved position.
Statistics
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PSSM-Id: 173842
View PSSM: cd01153
Aligned: 8 rows
Threshold Bit Score: 589.36
Threshold Setting Gi: 34540558
Created: 26-Mar-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:FAD binding site [chemical binding site]
Evidence:
  • None

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                       
NP_532104    28 ILNEAARFAETVLEPlntpaDREGCTVVDGRVrvptg--fadaFRRHAGDGWLamdvPERFGGQALPlvlqaacaplfe- 104 Agrobacterium tu...
NP_519883    41 ALDTCERIATDLFAPhnkknDQQEPHFDGTAVhiipe--vktaLDAFNKAGLMaagqDFERGGMQLPtvvekagfgffka 118 Ralstonia solana...
NP_214758    41 MLAEVSRLAEGPVAEsfvegDRNPPVFDPKTHsvmlpesfkksVNAMLEAGWDkvgiDEALGGMPMPkavvwalhehil- 119 Mycobacterium tu...
NP_733617    41 VLEELTRLSENELAEsfadaDRNPPVFDPETNtapvpasfkksYQAFMDSEYWrlglPEEIGGTTSPrsliwayaelil- 119 Streptomyces coe...
NP_106251    41 ILAEGAKLAENVMHPlnrvgDMEGCVRHDDGSvttpk-gfkeaFDQYREGGWMglaaPVEFGGQGLPyavhtavaeymvs 119 Mesorhizobium loti
ZP_00054042  35 VLTHAAAMVDEVIAPldplgDTEGTKLVDGRVvmpqp--fveaYRQFAGDGWQglavPEEDGGQGLPhilasalsemlsg 112 Magnetospirillum...
NP_713856    55 VLETVGDLAGNILSPhvadlDREGLKFKNGKVefppk--mlelVSKVIEAGVQaygfSRKYGGLGIPwtvksfiseify- 131 Leptospira inter...
NP_905037    54 VLEIVGEICGDIIAPnaesvDHEGPTLHDGRVayaag--tkqnLKAITDAGLMgismPRRYGGLNFPitpyimaadivs- 130 Porphyromonas gi...
Feature 1                                                   # ##    ##                          
NP_532104   105 rgcvalmmasgsTRAACHLLAEtAEGAVADEWVPRLAAgeWAATICISEPDAGSDLARLRSRAVFR-----EGAWRIEGR 179 Agrobacterium tu...
NP_519883   119 anvgtssypfltIGNANLLLAH-GTPAQIETFVQPELEgrFYGTMCLSEPQAGSSLSDIATRAEYEgesplGPQYRLTGN 197 Ralstonia solana...
NP_214758   120 -ganpavwmyagGAGFAQILYH-LGTEEQKKWAVLAAErgWGSTMVLTEPDAGSDVGAARTKAVQQa----DGSWHIDGV 193 Mycobacterium tu...
NP_733617   120 -ganpavwmyssGPAFAGILFE-EGNEVQKHIASIAVEkqWGSTMVLTEPDAGSDVGAGRTKAVEQa----DGSWHIEGV 193 Streptomyces coe...
NP_106251   120 anmslmmypgltQGAIAAIITH-GTDEQKAKWLPKMVEgaWTGTMNLTEPHCGTDLGLLRTKAVPDg----NGTYKISGQ 194 Mesorhizobium loti
ZP_00054042 113 acityqmvlslaHGAMRTLAAS-GSEAQRAAWIPRLAAgeVLATMCLTEAQAGSDLGLVRTMASPQa----DGSWSISGG 187 Magnetospirillum...
NP_713856   132 rvdaslaiaigcVNLAEILERH-ATEQMKSDWIPHFADgkFVCAMGLTEPDHGSDLSNLRTKATKDk----NGNWTLNGT 206 Leptospira inter...
NP_905037   131 radagfeniwglQDCAETLYEF-GNEDQRERFIPRVCAg-ETMSMDLTEPDAGSDLQAVMLKATYSe---aDGCWYLNGV 205 Porphyromonas gi...
Feature 1         # #                                                                           
NP_532104   180 KIWISFGdhd-maMRIGHCLLARTge-----etGTRGLSLFLVPDeidg-------ernGVTVErieeKMGLHGSPTCAL 246 Agrobacterium tu...
NP_519883   198 KMWISAGeha-lsDNIVHLVLAKIpgpdgkpipGVKGISLFIVPKflvgadg-algernDVALAglnhKMGYRGTTNCLL 275 Ralstonia solana...
NP_214758   194 KRFITSGdsgdlfENIFHLVLARPega----gpGTKGLSLYFVPKflfdvetgepgernGVFVTnvehKMGLKVSATCEL 269 Mycobacterium tu...
NP_733617   194 KRFITSGehd-msENILHYVLARPega----gpGTKGLSLFLVPKyefdfetgelgernGVYATnvehKMGLKASNTCEM 268 Streptomyces coe...
NP_106251   195 KIFISAGehd-msENIVHLVLARIega----peGVKGISLFIVPKfkldasg-npgernTLSCGsieeKMGIHGNSTCVM 268 Mesorhizobium loti
ZP_00054042 188 KIFISGGdqnltgGKIMHLVLARTpda----paGVKGLSLFLCPShldd------gtrnAIQVVrleeKMGMHASPTCQV 257 Magnetospirillum...
NP_713856   207 KRFITHGcgf-gdLPAVLLTLARSgei----nsGARGLSFFLVQSt-------------DVQIAgienKLGLHCSPTCEV 268 Leptospira inter...
NP_905037   206 KRFITNG------DSHIHLVLARSeeg----ttDARGLSMFIYDHrd-----------gGVTVRrtenKMGIKGAPTCEL 264 Porphyromonas gi...
Feature 1                                                                                       
NP_532104   247 RFDGARGL----------------LLGEEGRGL-AQLFAMIELMRLQTGCQGLGLASAAIDIAETYAQERQQggdp---- 305 Agrobacterium tu...
NP_519883   276 NFGEGTQFrpkgpdgqpragaigyLVGEPHQGL-ACMFHMMNEARIGVGMGATMLGYTGYLHALDYARNRPQgrpigpag 354 Ralstonia solana...
NP_214758   270 AFGQHGVPak------------gwLVGEVHNGI-AQMFEVIEQARMMVGTKAIATLSTGYLNALQYAKSRVQgadltqm- 335 Mycobacterium tu...
NP_733617   269 TFGDRHPAkg-------------wLIGDKHDGI-RQMFRIIEFARMMVGTKAISTLSTGYLNALEYAKERVQgpdlanf- 333 Streptomyces coe...
NP_106251   269 NYDEAEGT----------------LLGEENGGL-KAMFTMMNEARLGVGLQGLSLSEIAYQNAVAYAKDRLQgrslsga- 330 Mesorhizobium loti
ZP_00054042 258 AFDGAKAE----------------IIGAPGEGL-ARMFTMMNAERLDVAVQGVGLAEVALQRSLAYANERKQgrag---- 316 Magnetospirillum...
NP_713856   269 VFENSPGL----------------LIGEEGYGLiKYTMGMLNGARMGIAQQSTGLATAAYYEALKYAKERTQfgktl--- 329 Leptospira inter...
NP_905037   265 VFKNAKAE----------------LCGDRKMGLiKYVMALMNGARLGIMAQSVGLSEAAFREAHSYALDRKQfgkpi--- 325 Porphyromonas gi...
Feature 1                                                                                       
NP_532104   306 ---akpAVAIAHHPDIRRQLQEARLRTETLRAATLELATVMDLarmepkeel------rgdlqalsrWLLPLVKNFGADA 376 Agrobacterium tu...
NP_519883   355 kdaaspQVRIVDHADVRRMLLAQKAYVEGALGLNLYCAKLVDEergaesegdad---aratlgllldILTPIAKSWPSQW 431 Ralstonia solana...
NP_214758   336 tdktapRVTITHHPDVRRSLMTQKAYAEGLRALYLYTATFQDAavaevvhgvd-----aklavkvndLMLPVVKGVGSEQ 410 Mycobacterium tu...
NP_733617   334 mdkaapKVTITHHPDVRRSLMTQKAYAEGMRALVMYTASVQDEiqvkeanged-----asaehalndLLLPVVKGYGSEK 408 Streptomyces coe...
NP_106251   331 kapdkkADPIIVHPDIRRSLMTMKAFNEAGRALALWTAIKSDIahrsaddkd------rqaaddytgLMTPVVKGVLTDK 404 Mesorhizobium loti
ZP_00054042 317 --kdagPDFIAKHGDVRRMLLTQMALAMGCRAMVMRTLVDLELgekp----------------almeLMTPVCKAFATEA 378 Magnetospirillum...
NP_713856   330 --ieipAVKKILDRIERETYAMRCLTLEGSRVMDRYYWRAIRLekqgatekeikndtvvrywekianILTPISKFYCSES 407 Leptospira inter...
NP_905037   326 --iafaPVYEMLSLIRAKADASRAMLYETSRFVDMYKVLEDISherkltseera---emkhfsrladAYTPMGKGMTSEF 400 Porphyromonas gi...
Feature 1                                      #      # #            
NP_532104   377 GFTVSNQAIQILGGAGYTREWpLEQYLRDARVMTIYEGTTGMQAIDLLTRRLW 429 Agrobacterium tumefaciens str. C58 (U. Wash...
NP_519883   432 CLEANSLAIQVHGGYGYTREYnVEQFYRDNRLNPIHEGTHGIQGLDLLGRKVV 484 Ralstonia solanacearum
NP_214758   411 AYAKLTESLQTLGGSGFLQDYpIEQYIRDAKIDSLYEGTTAIQAQDFFFRKIV 463 Mycobacterium tuberculosis H37Rv
NP_733617   409 AYEQLAQSLQTFGGSGFLQEYpIEQYIRDAKIDTLYEGTTAIQGQDFFFRKIV 461 Streptomyces coelicolor A3(2)
NP_106251   405 GFDHAVMAQQVFGGHGYIEEHgMSQFVRDARIAMIYEGANGIQALDLVGRKLG 457 Mesorhizobium loti
ZP_00054042 379 AMEAADHAIQVHGGYGFLREYrVEQILRDGRITRIYEGTNGIQAATVAGRVIR 431 Magnetospirillum magnetotacticum
NP_713856   408 CLKTVSDALQVHGGSGYTEDYdISRIYRDARIVTIYDGTSQIQINACIGGITS 460 Leptospira interrogans serovar lai str. 56601
NP_905037   401 ANQNVYDCVQIHGGSGFMKDYtCERLYRDVRITNIYEGTTQLQVVAAIRHITT 453 Porphyromonas gingivalis W83

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