Conserved Protein Domain Family
ACAD_fadE6_17_26

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cd01152: ACAD_fadE6_17_26 
Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26
Putative acyl-CoA dehydrogenases (ACAD). Mitochondrial acyl-CoA dehydrogenases (ACAD) catalyze the alpha, beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. The mitochondrial ACD's are generally homotetramers and have an active site glutamate at a conserved position.
Statistics
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PSSM-Id: 173841
View PSSM: cd01152
Aligned: 12 rows
Threshold Bit Score: 462.973
Threshold Setting Gi: 23017625
Created: 26-Mar-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:FAD binding site [chemical binding site]
Evidence:
  • Comment:based on similarity to other acyl-CoA dehydrogenases

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                       
NP_216450     7 PEAEAFRDRIREFVaehlppgwpgpga--------lpphereefarhWRRALAGAGLVAVSWPteYGGGGlspmeqVVLA 78  Mycobacterium tu...
ZP_00081765   7 SRESAILEEVRRFLksevtpellaesh-------hleyiyggeegrkFVRKFAANGWLTPCWPeeYGGLNssemlmYAIR 79  Geobacter metall...
NP_770088    17 LAGAAYRDAVHRWLhanlpasfrgdsa--------afapptlqqsvtWEAAMYRAGLTGITWPqaYGGHGrslrehLIAN 88  Bradyrhizobium j...
NP_825016     7 PEEEEFRAGLRTWLakalpslppkpsp--------ddwparraydlgWQRMLYDAGYAGLHWPldAGGRGatptqhLIFL 78  Streptomyces ave...
ZP_00011287   7 PQEAEFRAKARAWIdanapkqyeeelrkaslgrvvlkganilevakaWQKKKADAGWAVPHWPkeYGGRGaspierVIWQ 86  Rhodopseudomonas...
ZP_00026060   7 PSLQAFRQEVREFLreslppdlprrk---------ggfrspradlarWQGILHAKGWGAPYWAseHGGTGwtvpqrLIFD 77  Ralstonia metall...
ZP_00095291  51 PEQQAFRTEVRAWLeahvpkeplehy---------datregfeahrrWEATLKSGDWGMVTWPkeYGGRGvdliqwLIFE 121 Novosphingobium ...
ZP_00026225  17 DSDEAFRAEIRSFLrnavpadiraatr--------ahclvtreqaarWHRILHAQGWAAPGWPreHGGTGwslvrqAIFR 88  Ralstonia metall...
NP_625488     2 TDAAELRDRTRELLaahppa---------------------dtdrldFLRARFDAGLAWVHYPqgLGGLGapralqAVVD 60  Streptomyces coe...
NP_218021     7 PQQEELRRELRSYFatlmtperrealss------vqgeygvgnvyreTIAQMGRDGWLALGWPkeYGGQGrsamdqLIFT 80  Mycobacterium tu...
ZP_00057350 330 EAAERFRAEVRALLaehrtvdeh---------------greeydregLRAAMAERGLFSLGWPeeLGGRRagvaerAVLN 394 Thermobifida fusca
NP_214785   367 PSTEKLRAQIRAEVaalka-----------------------mprepRTVAIAEGGWVLPYLPkpWGRAAspv-eqIIIA 422 Mycobacterium tu...
Feature 1                                                          # ##    ##                   
NP_216450    79 EEFARAGAPeraen-dllgiDLLGNTLIALGSEAQKRHFLPRILSgeHRWCQGFSEPEAGSDLASVRTRGVLDGDEWVIN 157 Mycobacterium tu...
ZP_00081765  80 NEMAYARVPihf-----agaHMAGPSILRYGNDDLKKNYLLRLASgeIEFALGYSEPAAGSDLMGLEMRAADKGDHLIVN 154 Geobacter metall...
NP_770088    89 QEIGALAMPesvn---sigkELAGPIILAVGSEEQKRRFLPAILEmrNIWCQGFSEPEAGSDLAGLRTRATRNGNDWQIT 165 Bradyrhizobium j...
NP_825016    79 EETEKAGAPyvgan--fvglLHAGPTIAAEGTPEQRARWLPPVLRgeEVWCQGFSEPDAGSDLAALRTRAWRDGDDYVVS 156 Streptomyces ave...
ZP_00011287  87 QEEGVFGKLtamf---iigqGMCGPTMMAYASEEQKRHYLPPLGSgeKIWCQLFSEPAGGSDVAGLRTRAEKDGDDWIIN 163 Rhodopseudomonas...
ZP_00026060  78 EECSAAGAPtqdg----faqKLVGPVLNYFATPEQRAAHVPAILAgkRMWCQGFSEPGSGSDLASLRTRAERDGDHYVVN 153 Ralstonia metall...
ZP_00095291 122 EEYYRSGAPgrvn---qngiFLLGPTLMEFGTHEQKSRFLPPMASgeEIWAQAWSEPQAGSDLAGVRATAVRDGDEYVLN 198 Novosphingobium ...
ZP_00026225  89 EELAASDAPyien----lgiDTIGPTLIRHGTDEQCKRFLPGMLSfdDFWAQGYSEPDAGSDLAALRTTARREGDCWIVN 164 Ralstonia metall...
NP_625488    61 AELAAAGAPdndprrigiglGMAAPTILQYGTEEQKRRLLRPLWTgeEVWCQLFSEPGAGSDLAALGTRAVRDGEDWVVN 140 Streptomyces coe...
NP_218021    81 DEAAIAGAPvpf-----ltiNSVAPTIMAYGTDEQKRFFLPRIAAgdLHFSIGYSEPGAGTDLANLRTTAVRDGDDYVVN 155 Mycobacterium tu...
ZP_00057350 395 EEMKYACGPvdra---msatMLLGHSILRHGTPQQQAEFLPLIRRgeLRFCLGYSEPEAGSDLASLRTRAVRDGDHWVIN 471 Thermobifida fusca
NP_214785   423 QEFTAGRVKrpqi----aiaTWIVPSIVAFGTDNQKQRLLPPTFRgdIFWCQLFSEPGAGSDLASLATKATRVDGGWRIT 498 Mycobacterium tu...
Feature 1           # #                                                                         
NP_216450   158 GHKIWTSAGtTANWIFLLARTdps---aaKHRGLSFLLVPMdqpGVVVRPivnaAGHSSFSEVFLTDARTSAgnVVGRVG 234 Mycobacterium tu...
ZP_00081765 155 GQKTFNTHAhVADYHWLAVRTnle---gpKHKGISILIVDLkspGITIRPmi-tMAGTRTNEVFYDDVVVPRanLVGEIN 230 Geobacter metall...
NP_770088   166 GQKIWTSGAyRAQRCLVLARTgpl---edRHRGLAMFAVPLdadGVRVRTiksiDGRESFCEVFFDDVEVAQadAIGAPD 242 Bradyrhizobium j...
NP_825016   157 GSKIWTSHAeVADWCELLVRTdpa---apKHRGISWLALRMdapGVTVRPlrtlAGSTEFAEVFLDDVRVPVahRVGAEN 233 Streptomyces ave...
ZP_00011287 164 GQKIWTSGAhYSDYGILITRTdpt---vpKHKGLTMFFLDMkseGVEVRPikqaNGNSDFNEVYFTNVRIPDsqRLGAVG 240 Rhodopseudomonas...
ZP_00026060 154 GQKIWTSYGhEADWIFLLVRTdtq---vkKQAGISFLLVDMktpGITVRPiisiDGAHHLNETFFEDVRVPVsnLVGAEG 230 Ralstonia metall...
ZP_00095291 199 GHKIWSSRAaFADWAFGLFREpg----seRHKGMSLIFFRLdqpGVTRNPirkiNGHVGFAEIFLEDVRVPAfnRLGQEG 274 Novosphingobium ...
ZP_00026225 165 GSKIWQSLGhWANWALLLVRTdpa--asrKQDGISILLVDLrtpGVTVRPiryiNGSHFHVQMFFDDVRVPAanLVGEPN 242 Ralstonia metall...
NP_625488   141 GQKVWTSSAhLARWAILIARTdpd---vpKHQGITYFVCDMtdpGVEVRPlrqiTGEAEFNEVFLTDVRIPDsrRLGEVG 217 Streptomyces coe...
NP_218021   156 GQKMWTSLIqYADYVWLAVRTnpessgakKHRGISVLIVPTtaeGFSWTPvh-tMAGPDTSATYYSDVRVPVanRVGEEN 234 Mycobacterium tu...
ZP_00057350 472 GQKVWTTRAhTASHVWLAVRTdpd--avpRHAGITIFLVPMdtpGITVQQht-aLSGEVSCTVFYDNVRVPDsmRVGEVN 548 Thermobifida fusca
NP_214785   499 GQKIWTTGAqYSQWGALLARTdps---apKHNGITYFLLDMkseGVQVKPlrelTGKEFFNTVYLDDVFVPDelVLGEVN 575 Mycobacterium tu...
Feature 1                                                                                       
NP_216450   235 DGWstamtLLGFERGSHIATAAIDFERDLQRLCelard---------rglhtDPRVRDGLAWCYARVQIMRYRGYRDLTL 305 Mycobacterium tu...
ZP_00081765 231 SGFkyimaALDFERMFPFGHYKKFYEDLVAYLKtvtrng--------mpltkDPLVRQKLAQLEIELEIIHHLYFQLAHM 302 Geobacter metall...
NP_770088   243 EGWaaairVLEIERATNRMYRAWRFENELRHLIsacktdp-----alsamvaDRHYAVRLGEVAVEIEVLKAHVETAVEA 317 Bradyrhizobium j...
NP_825016   234 DGWrvtmvTLSFERGTAFVGEVVACRRVLGELAreahr---------ngrwdDPVLRRHLGRLNAEFRALWRLTQWNVSE 304 Streptomyces ave...
ZP_00011287 241 DGWnvsltTLMNERMSIGANVATGFPELFDYCSsltldg--------apaldDRAVRSKLANWAVKASGLRYTSFRSISA 312 Rhodopseudomonas...
ZP_00026060 231 EGWkltkfLLNNEHASTADLPTLQRFQRQLRALaatrgag------ggtligRHEFALRLARLEAELQAITVMVQRVAAM 304 Ralstonia metall...
ZP_00095291 275 EGWhicmaTAGFERGLMLRSPARFQEAAAALSHlwqar----------khdcDPCLEAEVVRAHMNADAYALSIYQTASR 344 Novosphingobium ...
ZP_00026225 243 GGWaiakgLLVIERLFVARVAECKAELARAAALlhpppgegdpamrgeqemaFALTARRHAALEIRMRALEAAWWPAIQQ 322 Ralstonia metall...
NP_625488   218 DGWrvaqtTLNNERVAIGGTPIPREGGMIGKIAetwre---------rpelrTHDLHQRLLGLWVEAEVARLTGVRLRQQ 288 Streptomyces coe...
NP_218021   235 AGWklvtnQLNHERVALVSPAPIFGCLREVREWaqntkda-----ggtrlidSEWVQLNLARVHAKAEVLKLINWELASS 309 Mycobacterium tu...
ZP_00057350 549 GGWrvitdALAAERVVMGGVAATLLRQLDDLLGylradpq------rllgaeDSAARDRLEGLAARLQATRALVLEATRA 622 Thermobifida fusca
NP_214785   576 RGWevsrnTLTAERVSIGGSDSTFLPTLGEFVDfvrdyr--------fegqfDQVARHRAGQLIAEGHATKLLNLRSTLL 647 Mycobacterium tu...
Feature 1                                                                                       
NP_216450   306 ALTgrp---pgaEAAITKVIWSEYFRRYTDLAVEILGlealgprgpgnggarlvpeagtpnspacWMDELLYARaaTIYA 382 Mycobacterium tu...
ZP_00081765 303 LDNgki---pnyQASMEKNFLTDFEQRLANTALEILGargqlrega-----------ngaildglPEWLYRWTVieTIYG 368 Geobacter metall...
NP_770088   318 LVNgdk---igaRGSLAKLYWSESHQRFAALAIELLSqaslpqnp------------aitvarrrFEAIYLQARaeTIYA 382 Bradyrhizobium j...
NP_825016   305 AQStggv--pgvGGSVFKLRYSHARQELYDAAAEVLGpdaad-------------------lgreWTLDRLSSLsyTIAA 363 Streptomyces ave...
ZP_00011287 313 LSKgqr---pgpENSIGKLVAGSMIQEVAMYALDLQGaagvlsgp------------edaevagrFQAMLLRSPatRVEG 377 Rhodopseudomonas...
ZP_00026060 305 EADhspa--ahaMGSILKVRGTELQQKMSEFLVEALGdhgavaypgshaatagarslpmqevaqsIAADMLFRRatTIYG 382 Ralstonia metall...
ZP_00095291 345 LMAgak---igpEASTNKIFWSEMDIHLHETALAILGpeaelvp---------------ptgdheWLDDYIFSLagPIYA 406 Novosphingobium ...
ZP_00026225 323 AAEggr---pdlEASLLKLEGIQLLQDLHLFRMDTHGtaslrlypealdgq-ppgvpddaasagnQTLHMWRYRgsSLAG 398 Ralstonia metall...
NP_625488   289 LAAgqp----gpEGAGMKLNFARLNQEISGLEVELLGaegllyddwtmr-----rpelvdftgrdAGYRYLRSKgnSIEG 359 Streptomyces coe...
NP_218021   310 QSGpkdagpspaDASAAKVFGTELATEAYRLLMEVLGtaatlrqns-----------pgallrgrVERMHRACLilTFGG 378 Mycobacterium tu...
ZP_00057350 623 MAEgka---sdlAAPMAGVLGGELAEDFGQGVLELLGpeaalgaev-----------pgvpghgvFERALRTSPmfVIGG 688 Thermobifida fusca
NP_214785   648 TLAggd---pmaPAAISKLLSMRTGQGYAEFAVSSFGtdavigd--------------terlpgkWGEYLLASRatTIYG 710 Mycobacterium tu...
Feature 1                       
NP_216450   383 GSSQIQRNVIGERLLG 398 Mycobacterium tuberculosis H37Rv
ZP_00081765 369 GTAEIQRNIMAQRGLG 384 Geobacter metallireducens
NP_770088   383 GTTEIQLGIIADRILQ 398 Bradyrhizobium japonicum USDA 110
NP_825016   364 GTSQIQRNIVAERILG 379 Streptomyces avermitilis MA-4680
ZP_00011287 378 GTDEILRNIIAERVLG 393 Rhodopseudomonas palustris
ZP_00026060 383 GTSEVQRGIIAKSLFQ 398 Ralstonia metallidurans
ZP_00095291 407 GSNEIQRNIIAERMLG 422 Novosphingobium aromaticivorans
ZP_00026225 399 GSSEIQRQIIAKAIFD 414 Ralstonia metallidurans
NP_625488   360 GTSEVLLNIVAERVLG 375 Streptomyces coelicolor A3(2)
NP_218021   379 GTNEVQRDIIGMVALG 394 Mycobacterium tuberculosis H37Rv
ZP_00057350 689 GTNDIQRAIIARGLGL 704 Thermobifida fusca
NP_214785   711 GTSEVQLNIIAERLLG 726 Mycobacterium tuberculosis H37Rv

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