1IS2


Conserved Protein Domain Family
AXO

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cd01150: AXO 
Click on image for an interactive view with Cn3D
Peroxisomal acyl-CoA oxidase
Peroxisomal acyl-CoA oxidases (AXO) catalyze the first set in the peroxisomal fatty acid beta-oxidation, the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. In a second oxidative half-reaction, the reduced FAD is reoxidized by molecular oxygen. AXO is generally a homodimer, but it has been reported to form a different type of oligomer in yeast. There are several subtypes of AXO's, based on substrate specificity. Palmitoyl-CoA oxidase acts on straight-chain fatty acids and prostanoids; whereas, the closely related Trihydroxycoprostanoly-CoA oxidase has the greatest activity for 2-methyl branched side chains of bile precursors. Pristanoyl-CoA oxidase, acts on 2-methyl branched fatty acids. AXO has an additional domain, C-terminal to the region with similarity to acyl-CoA dehydrogenases, which is included in this alignment.
Statistics
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PSSM-Id: 173839
View PSSM: cd01150
Aligned: 11 rows
Threshold Bit Score: 773.425
Threshold Setting Gi: 23019011
Created: 26-Mar-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1IS2_A; rat acyl-CoA oxidase bound to FAD
    View structure with Cn3D
  • Comment:extreme C-terminal domain has a role in acyl-CoA binding

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                       
1IS2_A        3 PDLRKERasat-------------fnpELITHILDg-sPENTRRRREIENLILNdpdfqhe-------dynfltRSQRYE 61  Norway rat
NP_611264     8 PDLQKERstat-------------fnpREFSVLWAg-gEERFKEKKALEKLFLEdpalqdd------lpisylsHKELYE 67  fruit fly
CAA64488     20 PDIDSERhsps-------------fsvERLTNILDg-gLPNTVLRRKVESIIQSdpvfnlk-------klyfmtREELYE 78  Norway rat
AAH54613     11 GPLDIYRkkas-------------fswKDMMRFLEg--DELIAFKQHVFRTLESdplfarqpg---edvpveqkRELTFL 72  zebrafish
O15254       19 GPLDAYRaras-------------fswKDVALFTEg--EGNVRFKKTIFSALENdplfarspg---adlslekyRELNFL 80  human
ZP_00058724   3 QHGDTARvd-----------------vEALRDLLDgrwAAVRRRARDILRGPEFtprygl---------svaehRARVTE 56  Thermobifida fusca
NP_201316    42 PLVQTETcsa---------------rsKKLDVNGEa-lSLYMRGKHIDIQEKIFdffnsrpdlqtpieiskddhRELCMN 105 thale cress
NP_609961    16 GPLAVYRkran-------------fdwKRLRLIFEk--EQGLRIKYKVWRRLENdplf------------ahpsRTLPMD 68  fruit fly
NP_500943     4 PLIDKYRkmat-------------fdwKKLKAAVEg--EEHVRLKSEVVAKMKSepvfhr--------dyrvlsREEQRE 60  Caenorhabditis e...
P34355       13 QDLTDERfkat-------------fdtDALAAVFHg-gEDALKRIRELRDEVTKrwhlfda------lpgahrtRAERME 72  Caenorhabditis e...
P13711       18 KFIQKERadskikvdqvntflessperRTLTHALId-qIVNDPILKTDTDYYDAkkmqere------itakkiaRLASYM 90  baker's yeast
Feature 1                                                                            #          
1IS2_A       62 VAVKKSATMVKKMREYgi----------sdPEEIMWFKNSVHrgh---------------pepLDLHlGMFLPTLLHQAT 116 Norway rat
NP_611264    68 HSLRKACIIGEKIRKLra-----------dGEDGVDTYNALLggslgsa-------ilkegnpLALHyVMFVPTIMGQGT 129 fruit fly
CAA64488     79 DAIQKRFHLEKLAWSLgws--------edgPERIYANRVLDGnv------------------nLSLH-GVAMNAIRSLGS 131 Norway rat
AAH54613     73 RCKQLFKYDFITREELmq-----------nPWKMTVLNDCLGmydws------------lcakYFLNkGMFGATVVNTGS 129 zebrafish
O15254       81 RCKRIFEYDFLSVEAMfk-----------sPLKVPALIQCLGmydss------------laakYLLHsLVFGSAVYSSGS 137 human
ZP_00058724  57 QLHALARTDLARYGFDpryggrgevgasvaAFEMLVCDLSLMv-------------------kMGVQwGLFGGAIQALGT 117 Thermobifida fusca
NP_201316   106 QLIGLVREAGVRPFRYva----------ddPEKYFAIMEAVGsvdms------------lgikMGVQySLWGGSVINLGT 163 thale cress
NP_609961    69 EQKRLCAMQVNRMKHLdl-----------vPKEIESLSFSAKtkylmyinealacyspslsvkIALGvGLFNNAIRAMGT 137 fruit fly
NP_500943    61 VVHQRWKKIVEWGLFKdpy---------sdLENFHALTETLEaydqg------------tsarLFLHgNVFGAAVKSMGT 119 Caenorhabditis e...
P34355       73 DVSRKLKNLMESVGEFadf---------tnNLDMLVIIRDVMgie---------------gfpLALHnLMFVPTIQNQAD 128 Caenorhabditis e...
P13711       91 EHDIKTVRKHFRDTDLmkel------qandPDKASPLTNKDLfifdkrlslv-anidpqlgtrVGVHlGLFGNCIKGNGT 163 baker's yeast
Feature 1                             ####                                    ###               
1IS2_A      117 AEQQERFFMPAWNl---eITGTYAQTEMGHGTHLRGLETTATYDPktQEFILNSPtvtSIKWWPGGLgKTSNHAIVLAQL 193 Norway rat
NP_611264   130 MDQQVEWLSKAWDc---eIIGTYAQTELGHGTFLRGLETRADYDAstQEFVINTPslsAYKWWPGGLgHTANHAVVVAQL 206 fruit fly
CAA64488    132 DEQIAKWGQLCKNf---qIITTYAQTELGHGTYLQGLETEATYDEarQELVIHSPtmtSTKWWPGDLgWSVTHAVVLAQL 208 Norway rat
AAH54613    130 QRHLKFVKDIERMm----TFGCFSLTELSHGSNTRALRTTAKYDPntQEFVINSPdfeAAKFWVGNLgKTATHSVVFAQL 205 zebrafish
O15254      138 ERHLTYIQKIFRMe----IFGCFALTELSHGSNTKAIRTTAHYDPatEEFIIHSPdfeAAKFWVGNMgKTATHAVVFAKL 213 human
ZP_00058724 118 EYHHATYLPGVMSl---eIPGCFAMTETGHGSDVQRLRTTATFDPntDEFVVHTPdeaARKDYIGNAaRDGRLAVVFAQL 194 Thermobifida fusca
NP_201316   164 KKHRDKYFDGIDNl---dYTGCFAMTELHHGSNVQGLQTTATFDPlkDEFVIDTPndgAIKWWIGNAaVHGKFATVFARL 240 thale cress
NP_609961   138 EKHQKYIEAAWNRe----VITCLAITELSHGSNTKSIRTTATYDPttQEFVINTPdfeAAKCWVGNLgKTATVAMTFANL 213 fruit fly
NP_500943   120 DRHKDLIQKTENNe----IVGAFCLTEVGHGSNTAEIQTTATFDN--GELVFNTPsvsAIKCWAGNLaHSATHVVVYAQL 193 Caenorhabditis e...
P34355      129 DEQTEWWLMDALQg---kIIGTYAQTELGHGTNLGAIETTATYDKltEEFIIHTPtttATKWWPGGLgTSCTHVVLVANL 205 Caenorhabditis e...
P13711      164 DEQIRYWLQERGAtlmkgIYGCFAMTELGHGSNVAQLQTRAVYDKqnDTFVIDTPdltATKWWIGGAaHSATHAAVYARL 243 baker's yeast
Feature 1                                                    #                                  
1IS2_A      194 ITQ------GECYGLHAFVVPIREigthkplPGITVGDIGPKf-GYEEMDNGYLKMDNYRIPRENMLmk--yAQVKPDGT 264 Norway rat
NP_611264   207 YTK------GEFRGLAPFIVQLRDsdthrpmPGIDIGDIGTKl-GMKGVNNGYLGLKNVRVPLNNMLmk--nQQVLPDGT 277 fruit fly
CAA64488    209 TCL------GVRHGMHAFIVPIRSledhtplPGITVGDIGPKm-GLEHIDNGFLQLNHVRVPRENMLsr--fAEVLPDGT 279 Norway rat
AAH54613    206 YTPd-----GKCHGLHSFIVQVRDpktllamPGVMVGDMGKKl-GQNGLDNGFAVFHNVRIPRENLLnk--tGDVAPDGQ 277 zebrafish
O15254      214 CVPg-----DQCHGLHPFIVQIRDpktllpmPGVMVGDIGKKl-GQNGLDNGFAMFHKVRVPRQSLLnr--mGDVTPEGT 285 human
ZP_00058724 195 ITG------GQRHGVHALLVPIRDadg-tvlPGIRIEDCGPKa-GLNGVDNGRIWFTQVRVPRTALLnr--yGDVAADGT 264 Thermobifida fusca
NP_201316   241 ILPthdskgVSDMGVHAFIVPIRDmkthqtlPGVEIQDCGHKv-GLNGVDNGALRFRSVRIPRDNLLnr--fGDVSRDGT 317 thale cress
NP_609961   214 YTAd-----GQNHGLHGFLIPIRDpktllsyPGVLVGDIGEKc-GLNGIDNGFVVFTNYRIPRDNLLnr--tSDVTPEGV 285 fruit fly
NP_500943   194 HVE------GKNEGFHGFVIQVRCprtfqtlPGITIGDMGSKpgCWQGVENGWMEFKNHRAPLSALLnk--gCDITPDGK 265 Caenorhabditis e...
P34355      206 IID------TKNYGLHPFFVPIRDrnsysvmSGVRVGDIGTKm-GVNCVDNGFLAFDNYRIPRRNMLmk--hSKVSKEGL 276 Caenorhabditis e...
P13711      244 IVE------GKDYGVKTFVVPLRDpstfqllAGVSIGDIGAKm-GRDGIDNGWIQFRNVVIPREFMLsrftkVVRSPDGS 316 baker's yeast
Feature 1                           #       #                                                   
1IS2_A      265 YVkpls----nklTYGTMVFVrs----fLVGNAAQSLSKACTIAIRYSAVRRQseik-qsepEPQILDFQTQQYKLFPLL 335 Norway rat
NP_611264   278 YVapkn----svlTYGTMMFVrc----aLIRDTAQSLAKASTIATRYSAVRRQspid-pnqpEPQIMDHTTQQLKLFPQI 348 fruit fly
CAA64488    280 YQrlgt----pqsNYLGMLVTrv---qlLCKGILPSLQKACIIATRYSVIRHQsrlr-psdpEAKILEYQTQQQKLLPQL 351 Norway rat
AAH54613    278 YVspfk---dpnkRFGASLGAlsggrvgITRMALVNLKLAVTVAVRFSATRRQfgpk--edeEIPVLEYQLQQWRLIPFL 352 zebrafish
O15254      286 YVspfk---dvrqRFGASLGSlssgrvsIVSLAILNLKLAVAIALRFSATRRQfgpt--eeeEIPVLEYPMQQWRLLPYL 360 human
ZP_00058724 265 YSspie---npnrRFFTMLGTlvrgrisVAGGAGMAAKTALAIAIRYGQVRRQflrp-gsdsEVALLDYLAYQRRLLPAL 340 Thermobifida fusca
NP_201316   318 YTsslp---tinkRFGATLGElvggrvgLAYASVGVLKISATIAIRYSLLRQQfgpp--kqpEVSILDYQSQQHKLMPML 392 thale cress
NP_609961   286 YEsvft---epgkVLGAALESfsagrigIMQESANTLCSAAVIAVRYSAVRKQfgpe-rhgeEMAILEYQLHQYRIFPYL 361 fruit fly
NP_500943   266 YVtsfk---saseKQSVSLGTlsvgrlgIIAKGMMACTFASTIAIRYSVARRQfgpvkgaenEIPVLEYPLQQYRLFPYL 342 Caenorhabditis e...
P34355      277 YTapsh----pkvGYTTMLYMrs----eMIYHQAYYLAMAMAISIRYSAVRRQgeik-pgtqEVQILDYQTQQYRIFPGL 347 Caenorhabditis e...
P13711      317 VTvktepqldqisGYSALLSGrv----nMVMDSFRFGSKFATIAVRYAVGRQQfapr-kglsETQLIDYPLHQYRVLPQL 391 baker's yeast
Feature 1                                                                                   #   
1IS2_A      336 ATAYAFHFVGRYMKETYLRINesigqg-----------dlselpELHALTAGLKAFTTWTANAGIEECRMACGGHGYSHS 404 Norway rat
NP_611264   349 AKAIVFKTTGDGIWNMYNVISgeieqg-----------nldrlpEMHALSCCLKAICSADAAAGVETCRLSCGGHGYMDC 417 fruit fly
CAA64488    352 AVSYAFHFTATSLSEFFHSSYsailkr-----------dfsllpELHALSTGMKATFADFCAQGAEICRRACGGHGYSKL 420 Norway rat
AAH54613    353 AAVYALEHFTKSFSMNFVEFQmgllmkdks------drqaelgrEIHALSCASKPLGSWTAQRGIQECREACGGHGYLAM 426 zebrafish
O15254      361 AAVYGLDHFSKSLFLDLVELQrglasgdrs------arqaelgrEIHALASASKPLASWTTQQGIQECREACGGHGYLAM 434 human
ZP_00058724 341 ARTYALHFAQEEMVSRLHDGFtdgpld------------eraqrELEAHAAGLKAVATWHAVDTIQTCREACGGAGYLAE 408 Thermobifida fusca
NP_201316   393 ASTYAYHFATVYLVEKYSEMKkthde--------------qlvaDVHALSAGLKSYVTSYTAKALSVCREACGGHGYAAV 458 thale cress
NP_609961   362 AAACVQKIATEELTSTYMEIIarsqadsng-----fdvltqnaaEIHALISSSKPLITWAARDAIQEAREACGGHGYLQA 436 fruit fly
NP_500943   343 SAAICIRIFQKKFVGHFTEYMmrvimgeks------delsefskEVHALSSGAKPVATWLGVESLGEARKACGGHGYLQM 416 Caenorhabditis e...
P34355      348 ARCFAFNTAAATVRQMTENCIkqlshg-----------nsdvlaDLHALSCGLKAVVTHQASQSIDQARQACGGHGYSDA 416 Caenorhabditis e...
P13711      392 CVPYLVSPVAFKLMDNYYSTLdelynasssaykaalvtvskklkNLFIDSASLKATNTWLIATLIDELRQTCGGHGYSQY 471 baker's yeast
Feature 1                      ##                                                               
1IS2_A      405 SGIPNIYVTFTPACTFEGENTVMMLQTARFLMKIYDQVRSgklvggmvsylndlpsqr-----iqpqqvavwptmvdins 479 Norway rat
NP_611264   418 SNFPTIYGMTTAVCTYEGENTVMLLQTARYLVKVYGQALNgeklvptvsyisd--------------ainqtkfvnfdgs 483 fruit fly
CAA64488    421 SGLPTLVARATASCTYEGENTVLYLQVARFLMKSYLQAQAspgatpqkplpqsvmyia-----tqrparcsaqtaadfrc 495 Norway rat
AAH54613    427 NRLGDMRDDNDPNCTYEGDNNVLLQQTSNYLLSWIQHKQEgkgriespletvnflddm----ssilqskftvgsveecmn 502 zebrafish
O15254      435 NRLGVLRDDNDPNCTYEGDNNILLQQTSNYLLGLLAHQVHdgacfrsplksvdflday----pgildqkfevssvadcld 510 human
ZP_00058724 409 NRLPQLRADTDVFTTFEGDNTVLLQLVGKSLLTNYRQEFGnldplgmakfaagqflgtviertaarslldrlvqaapgrg 488 Thermobifida fusca
NP_201316   459 NRFGSLRNDHDIFQTFEGDNTVLLQQVAADLLKRYKEKFQggtltvtwsylresmntyl---sqpnpvtarwegedhlrd 535 thale cress
NP_609961   437 AKLGQMRTDHDPLCTYEGDNNVLGQQASNWLLRQWSAKELetpigsvkflerrsel--------lalnyaslaqktpias 508 fruit fly
NP_500943   417 SRLNTLRDDNDPSQTFEGENFMILQQTSNILLGKAQSIGSietpmstmsflnq---------------kpskfsswssnp 481 Caenorhabditis e...
P34355      417 SYLPTLYTCSVGACTYEGENMVMLLQLSKYLMKAAAKAEKgeemaplvayl------------------vkpditetndk 478 Caenorhabditis e...
P13711      472 NGFGKGYDDWVVQCTWEGDNNVLSLTSAKSILKKFIDSATkgrfdntldvdsfsylkp-----qyigsvvsgeiksglke 546 baker's yeast
Feature 1                                                                                       
1IS2_A      480 LEGLTEAYKLRAARLVEIAAKNLQTHVShr------ksKEVAWNLTS-VDLVRASEAHCHYVVVKVFSDKlpk---iqdK 549 Norway rat
NP_611264   484 LRSIVKAFQFVAANKTRIAYEQIELRRKqg------ygTEVAANLCG-TFLTAAADLHGRAFLAQTAYTEllalsrevsP 556 fruit fly
CAA64488    496 PDVYTTAWAYVSTRLIRDAAHRTQTLMKsg------vdQHDAWNQTT-VIHLQAAKAHCYFITVKNFKEAvekl--dkeP 566 Norway rat
AAH54613    503 SAVPLAAYKWLVCFLLGESQKKLFEEKSsg------lgDFEARNNSQvYYCRSLAIAFIEHTVLQRFHDLiqde--qtpA 574 zebrafish
O15254      511 SAVALAAYKWLVCYLLRETYQKLNQEKRsg------ssDFEARNKCQvSHGRPLALAFVELTVVQRFHEHvhqp--svpP 582 human
ZP_00058724 489 DEDDLRNREWQRALLADRENHVLEGLARrlraapadadPFDVVNNVQ-DHVLLAARAHVDRLVFEAFASGvar---iedE 564 Thermobifida fusca
NP_201316   536 PKFQLDAFRYRTSRLLQNVAARLQKHSKtl-------gGFGAWNRCL-NHLLTLAESHIETVILAKFIEAvkn---cpdP 604 thale cress
NP_609961   509 WQFSLRCYEWLLCHLMAKTTAHIEGQLAag------ssKFEARNNSQvAGARELSLAYAEYYALTRYVDHvstl--tveA 580 fruit fly
NP_500943   482 VNDVLSAYRYLTYHLLQTTSAEAYRLKAsg------knSFEVRNEIQiHRAVNLSVAYTEHTMIHWVQQFlke---iedQ 552 Caenorhabditis e...
P34355      479 FAKMLSHFEHIARHRVMHAYRQMIEEEKqg------ieRDYAFANHS-VDWTKAARAHTKLFIARGFVKSvqe---vsdE 548 Caenorhabditis e...
P13711      547 LGDYTEIWSITLIKLLAHIGTLVEKSRSid------svSKLLVLVSKfHALRCMLKTYYDKLNSRDSHISdei----tkE 616 baker's yeast
Feature 1                                                                                       
1IS2_A      550 AVQAVLRNLCLLYSLYGISQKggdfle-gsiitGAQLSQVNARILELLtlIRPNAVALVDAFDFKDmtLGSVLGRydgnV 628 Norway rat
NP_611264   557 ELAEVLKVVLELYLVDACLNRigdflr-fidltDQDVTKLEVRLENCLkrFRPNAVSLVDSFDLHDrvLDSALGAydgnV 635 fruit fly
CAA64488    567 EIQRVLQRLCDLYALHGVLTNsgdflh-dgflsGAQVDMAREAFLDLLplIRKDAILLTDAFDFSDhcLNSALGCydghV 645 Norway rat
AAH54613    575 VLRSVLGRLCALYGLWTLTNHmailyqggyfsgGQPVDFIQTAILTLCgqLKDDAVALVDVFAPPDfiLNSPIGKsdgeL 654 zebrafish
O15254      583 SLRAVLGRLSALYALWSLKRHaallyrggyfsgEQAGEVLESAVLALCsqLKDDAVALVDVIAPPDfvLDSPIGRadgeL 662 human
ZP_00058724 565 GTRAVVERLCDLAALSLVEQErawfle-hgrltPARAKAVTATVNALCqeLRPHARDLVDAFGLNDewLAAPIALgaetA 643 Thermobifida fusca
NP_201316   605 SAKAALKLACDLYALDRIWKDigtyrn-vdyvaPNKAKAIHKLTEYLSfqVRNVAKELVDAFELPDhvTRAPIAMqs-dA 682 thale cress
NP_609961   581 PYASVLRLLFDVYAMWLLEKHmttfyvggfaagRDFSAAVRQLLLDSClkLKDVAVSVADAISPPDfaLNSVIARadglL 660 fruit fly
NP_500943   553 SVKPVLQKVLNLFSLFLLERHlatlyitgyasgGKFGEDLREKLRLAVaeLKPEAIALVDSIAPDDfiLHSALGAsdgkA 632 Caenorhabditis e...
P34355      549 AVHDVLTTLAELYLSYELIEMsadlta-ngylsESDVQQIRHQIYDSMrkTRRNAVSIVDSFDICDreLRSVLGRrdghV 627 Caenorhabditis e...
P13711      617 SMWNVYKLFSLYFIDKHSGEFqqfk----iftpDQISKVVQPQLLALLpiVRKDCIGLTDSFELPDamLNSPIGYfdgdI 692 baker's yeast
Feature 1                 
1IS2_A      629 YENLFEWAKK 638 Norway rat
NP_611264   636 YEHIFESTKK 645 fruit fly
CAA64488    646 YERLFEWAQK 655 Norway rat
AAH54613    655 YKNLWSTVMQ 664 zebrafish
O15254      663 YKNLWGAVLQ 672 human
ZP_00058724 644 RQDQQARARV 653 Thermobifida fusca
NP_201316   683 YSQYTQVVGF 692 thale cress
NP_609961   661 YENLQNEFMT 670 fruit fly
NP_500943   633 YEHIMEEFRK 642 Caenorhabditis elegans
P34355      628 YENLYKWAQM 637 Caenorhabditis elegans
P13711      693 YHNYFNEVCR 702 baker's yeast

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