Conserved Protein Domain Family
HutB

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cd01149: HutB 
Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism. A typical TroA protein is comprised of two globular subdomains connected by a single helix and can bind the metal ion in the cleft between these domains.
Statistics
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PSSM-Id: 238569
Aligned: 18 rows
Threshold Bit Score: 255.268
Created: 10-Jan-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative hemin
Feature 1:putative hemin binding site
Evidence:
  • Comment:based on sequence similarity to PsaA from Streptococcus pneumoniae
  • Citation:PMID 9862808

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                          #                                            
AAM28270     20 AERVVTLGGSVTEIVYALGQGgkVVGDDLSSLYPEAatKLPRVGYYRSVPLEGVLAlKPDLVLASEQAGPP----DTLKR 95  Bordetella avium
NP_253396    27 PQRWVSAGGSLSEWVVALGGEskLVGVDTTSQHPQAlkQLPSVGYQRQLAAEGVLAlRPDILIGTEEMGPP----PVLKQ 102 Pseudomonas aeru...
NP_051557    44 PKRVVALNATTVEMIYRLGKQktIVGTDVSGVYPLN--KIPSVGHWAQLPAEGIISlKPDLVIGTADNFAAgkngTVVQQ 121 Deinococcus radi...
NP_290082    50 AERIVVAGGSLTELIYAMGAGerVVGVDETTSYPPEtaKLPHIGYWKQLSSEGILSlRPDSVITWQDAGPQ----IVLDQ 125 Escherichia coli...
AAK38770     55 PTRVISAGSNVTEIIVALGAGdvLVGVDSSSRLPADs-KAATLGYIRQLPAEGMLAlRPDYVIGSDEMAPA----SALTA 129 Plesiomonas shig...
Q56991       26 AERIVTIGGDVTEIAYALGAGdeIVARDSTSQQPQAaqKLPDVGYMRTLNAEGILAmKPTMLLVSELAQPS----LVLTQ 101 Yersinia pestis
AAB94547     22 QERIVSAGSAVTELILALGAEqqLVAVDVTSEVPSSl-NLPTVGYHRRLAAEGLLTlEPTHLIGSDEMGPD----TALQQ 96  Vibrio cholerae
ZP_00024809  27 PARVVGLGGPATEIVYALDAGksMVGVDSSSIYPPAalKLPKVGYYRAFSVEGVVSlKPDLVLALDHAGPP----QALEQ 102 Ralstonia metall...
NP_719214    46 DIKLVSAGAGVTELVLALDAAdeLVAVDATSYVPEQlsSVAKLGYHRMLSAEGIMAlSPTLVVGSDVMGPE----TTLNV 121 Shewanella oneid...
ZP_00057210 118 VSRILPLNGGVAEIIYTLGLGdnVIGRDSTATFAEAe-DLPVVTQGHDISVEGVLSlNPTLVIADTWTGPY----EAIEQ 192 Thermobifida fusca
Feature 1                                                                                       
AAM28270     96 LSEVGVKVLRVSDEPs--lHSLETRIGQIAQALGvPSEGEKLWAEVRTKVQEAQDLp---------aSGLSAVLLMNRSG 164 Bordetella avium
NP_253396   103 LEGAGVRVETLSAKPd--lEALESNLKKLGDWLGvPQRAEAAELDYRQRLRRQADWiaaaq--ksqpAPGVLLVIGNAGG 178 Pseudomonas aeru...
NP_051557   122 LRAAGIKVLVLPATDtgglNGVKTRLNMLGQVYNvPNAAASLTKSFDTTMKAVTANkp-------kkAPKVIFLYAHSAS 194 Deinococcus radi...
NP_290082   126 LRAQKVNVVTLPRVPat-lQQMYANIRQLAKTLQvPEQGEALVTQISQRLERVQQNvat-----kkaPVKAMFILSAGGS 199 Escherichia coli...
AAK38770    130 LQQAKIPLTVLPSDTt--pEALKAQVTQIAALLHkEAAGQTLQTKIDQQLEQLAQTraqlqgkqhgkPLKAVYLLLHDGR 207 Plesiomonas shig...
Q56991      102 IASSGVNVVTVPGQTt--pESVAMKINAVATALHqTEKGQKLIEDYQQRLAAVNKTp---------lPVKVLFVMSHGGL 170 Yersinia pestis
AAB94547     97 LRSSGIQVNVINSDSt--pQGLLTRIDQIAQITHtEQHAQKLKENVQQQINALQAKrp-------ekPKKVLFLLLHEGR 167 Vibrio cholerae
ZP_00024809 103 LRKLGSKVVVVPSEPt--lAALDQRILGVAAALDvPKQGQALVDKLHTELRDIKPSa----------EGLRVLMVSSHTG 170 Ralstonia metall...
NP_719214   122 LKQANIKVVQLPSSAd--eQQLMSNIDTLAQSLNrTDKAAPLKQELHQRLDKLNKQkqqls--qhnaQPKILFMLLQEGR 197 Shewanella oneid...
ZP_00057210 193 LRDSGVTLVILDEVWs--lDGMYTRITEVAEMLGvPERGEQLVQRVQDQMAEVRDSlpe-----slrGSRVAFLYLRGSA 265 Thermobifida fusca
Feature 1                                                                                       
AAM28270    165 APQAa-GADTSADLILQLAGLKNVla---eQQGYKPLSAEGIGALAPEVIVITDASVLASGGmekl------yqqPGLAS 234 Bordetella avium
NP_253396   179 QLLVa-GRNTGGDWVLNRAGARNLa----tHEGYKPISVEALAALDPVAVVIADRSLEGDAAraal-----lkqnPGLAA 248 Pseudomonas aeru...
NP_051557   195 DASIy-GTEGGANELITLAGGKNAa----pFKDTKALTAEALVAINPDAIVMLERGLDGVGGlegl------lkmPGVAQ 263 Deinococcus radi...
NP_290082   200 APQVa-GKGSVADAILSLAGAENVa----tHQQYKSYSAESLIAANPEVIVVTSQMVDGDINrlr--------siAGITH 266 Escherichia coli...
AAK38770    208 PPMIa-GGNTPADTLLTLAGAVNPaa---aVRNYQTVSAESLLAMQPDLIVVSERNWTGDADsll-------akqPLLQN 276 Plesiomonas shig...
Q56991      171 TPMAa-GQNTAADAMIRAAGGSNAmq---gFSRYRPLSQEGVIASAPDLLLITTDGVKALGSseni------wklPGMAL 240 Yersinia pestis
AAB94547    168 AANVa-GSDTVPDTIIGLIGAHNPas--psITSYKPLSMESMIEMQPDMVLVSGRSLEKLGGadav-----lnavPMLAA 239 Vibrio cholerae
ZP_00024809 171 RMQAv-GENTAGDAMLKLLGATNAla---gQRGFKPFSAEAAAALRPDVIVTTSMSIDAVGSvdaf------laqPGLSA 240 Ralstonia metall...
NP_719214   198 GARVg-GKGTAADTIIALSGAKNIa----dFEGYKTLSQEGILALQPDVILLSNRSEKTDSQtnsqtthallkemPLLAH 272 Shewanella oneid...
ZP_00057210 266 GVYLlgGPGSGADALVAELGLEDAgtaiglDRAFTPITSEALIDAQPDILLVMTGGLKSVGGidgl------lkiPGISQ 339 Thermobifida fusca
Feature 1                       
AAM28270    235 TPAARRRCIVAMDDLL 250 Bordetella avium
NP_253396   249 TRAARDGRLLVLDPTL 264 Pseudomonas aeruginosa PAO1
NP_051557   264 TNAGRDKRVYTVDNSI 279 Deinococcus radiodurans R1
NP_290082   267 TAAWKNQRIITVDQNL 282 Escherichia coli O157:H7 EDL933
AAK38770    277 TPAGRNKAVLPINGKA 292 Plesiomonas shigelloides
Q56991      241 TPAGKHKRLLVVDDMA 256 Yersinia pestis
AAB94547    240 TPAGQNKNIVAIDGQP 255 Vibrio cholerae
ZP_00024809 241 TPAARDKRIVVMDDLL 256 Ralstonia metallidurans
NP_719214   273 TPAGQNGHIQTLAPQA 288 Shewanella oneidensis MR-1
ZP_00057210 340 TPAGKERRVLAYEDGL 355 Thermobifida fusca

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