Conserved Protein Domain Family
TroA_e

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cd01142: TroA_e 
Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. A typical TroA protein is comprised of two globular subdomains connected by a single helix and can bind their ligands in the cleft between these domains.
Statistics
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PSSM-Id: 238562
Aligned: 18 rows
Threshold Bit Score: 245.727
Created: 10-Jan-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative ligand
Feature 1:putative ligand binding residues [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                     ##                        #                                        
NP_616138     74 TDAEAETRTITDMDGVVWTIPkEVKSVVAN---GAGNQIVFMVGGADKLVGtas-----vvQQNEMFVKIYPRITEVet- 144  Methanosarcina...
NP_603212      1 MFANINAKTVTDLTGKKVTIKdNPNRIAIVp--IPWASLAYAVDGDSSKIVgmhps-akksYEISMLKELAPNMKNVnsv 77   Fusobacterium ...
ZP_00011857   52 MAGSAWAAELTDQRGRTVAVTtPAQRVVFLp--MPAPSTYMAIDRSAAHVTgmnpa-sataMRAGILSRIFPSFDQIptg 128  Rhodopseudomon...
ZP_00098239   38 EASTPTERTVTDMAGRTVTLPaEVKTVGTFgsiGVLNAFVETLSAGERLANegspsfvkspTWEKYQYQFTPHIKNLkp- 116  Desulfitobacte...
ZP_00103839   58 PAPAAAERTATDAKGREVKIPdKVEKIAITc-yGGATHEMTVLGFADAIVAqp------tmKSFPQLKKMFPQYETVid- 129  Desulfitobacte...
P44206        16 SFSALADRIITDQLDRKVTIPdHINRAVVLq--HQTLNIAVQLDATKQIVGvlsn---wkkQLGKNYVRLAPELENMam- 89   Haemophilus in...
ZP_00078086   60 DTVVSDTRVITDLAGRKITLPaDITRISVLh--PIPCQMVWRLAPEKLVSAd--------kQFTERLEFMSTDEEKRlla 129  Methanosarcina...
ZP_00092341  730 AGPLHAERLVTDMAGRQVKIPdEVRRVYAV---GHCVPMVGAVAPDKLANNf--------rLNDTAKRFLSPQFYEGkvv 798  Azotobacter vi...
ZP_00090854   19 SLATAQARQLTDMSGRTEEIPeRPQRVFPA---VTMMTPVMAALAPELMTGlafr---lapGAEAFLPAGVAGLPVV--- 89   Azotobacter vi...
NP_662637     29 KKPDAATREVVDMAGRRMTVPvTIDRAYAT---RPGSVTLYAVAPDLMVNRs---------LWMTDGAERFMSPAYLk-- 94   Chlorobium tep...
Feature 1               #                  # #                                                   
NP_616138    145 ---ifVTGQDVNFEELVKlDPDVIIGNLDDa-----EEYGLVDLD----IRNQSPEDI----------KKEVLLVGDLFG 202  Methanosarcina...
NP_603212     78 ---fvDNNFNINYEELALlKSDIVVVWDYQ------NDAIEKLAKl--kIPAVAIKYGt---------LEDVQQGIKLLG 137  Fusobacterium ...
ZP_00011857  129 --itrGAGVVPNVEAIMAlHPDAVLQWATSg-----DEPIAMLDRa--gLTVLGLRYGg---------QDEVEGAILMMG 190  Rhodopseudomon...
ZP_00098239  117 ---fqGADNELLMENILAaKPDVCLTMSTD------LTEQLEKQG----LNVVQLSWTk---------TEDVKECITLLG 174  Desulfitobacte...
ZP_00103839  130 ----pGSFNEVNIEEIIKaDPDMVFVGVSS------PEGNKKIEEagfpTYTMWIGWAa---------IDTLKQEFLNIG 190  Desulfitobacte...
P44206        90 ----pGDLNSVNIESLLAlKPDVVFVTNYAp-----SEMIKQISDvnipVVAISLRTGevgekgklnpTLTDEDKAYNDG 160  Haemophilus in...
ZP_00078086  130 lpingEFHSDMNIEDLLAvSPQVVITLTKDt----kIESEQKKVG----IPFIAASKDt---------LEEIADSWRLIG 192  Methanosarcina...
ZP_00092341  799 ---pgVNSRMLSDEELVKlAPDLVIMEAMPgaa-erADRLSARLQ----APVLLIDQD----------MHSYKPAFAFLG 860  Azotobacter vi...
ZP_00090854   90 -----PVLEDMNAEAILVmRPDLAIGWSGAgplmrrTETLMQRLR----IPALFYKGEr---------LDEYPATFRALG 151  Azotobacter vi...
NP_662637     95 -----LPFSDGSAEEIVKlHPDVIISYFAIn-----PQSIDQADRl--sQRTGIPVFMvd------meMKRYPEAFAAMG 156  Chlorobium tep...
Feature 1                                                            #                           
NP_616138    203 EEE--YKKAEEFCNYYDGNLNYVTERTkn---------lTDEEKVKVFV--AGADILSteGIGSITTSWIENAGGINVAa 269  Methanosarcina...
NP_603212    138 DILnrQEKAQKLINYHKDTNKYFASKTek---------lANTKRKKILY--IRDSQLTvaTGKSVNNIMIDMAGGVNVAk 206  Fusobacterium ...
ZP_00011857  191 RLAgqEARAGRIVERLRQRQDVLATTFra---------tPDAERPRVLHlsRASDSFAvaGRDTYTDFVIRTAGGRNAAg 261  Rhodopseudomon...
ZP_00098239  175 EVLnqQEVAADYLKYFDDMLAKTADLTkd---------iKDADKKTVVY--GNVSKFS--QPHVIAEWWIDKAGGISVTs 241  Desulfitobacte...
ZP_00103839  191 AIMgnEEQAKKLVAYWDEKLAALDTMLak---------vPESERKVVYY--TGADITKa-NTSDWAWTFIEEAGGVSAIs 258  Desulfitobacte...
P44206       161 LKQgiELIAEVFEKKQQGDELVKAAFAnrklladrlgdvSADKRVRTYM--ANPDLGTy-GSGKYTGLMMEHAGAYNVAa 237  Haemophilus in...
ZP_00078086  193 KIVgnEKEGNELGDYWDETIKKVTDQTsk---------iKESDKLKVYY--AQPDVTKtvGSRTIMASIISLAGGISFMe 261  Methanosarcina...
ZP_00092341  861 EVLqrPEQGRALADFVAAHLDPIEERArs---------iPADKRVRVYYa-EGPDGLStnPAGSSHTQVLDFVGGLNVAq 930  Azotobacter vi...
ZP_00090854  152 DALgrKVRGERLARYLEDSQVRLRQALrd---------lPESERPRVYYa-ESPDGLTtqCDSTSRMEVIRLAGGVPALs 221  Azotobacter vi...
NP_662637    157 ELLgrQEQAAKMTAYIEKWLLPVFAKAaq---------iPVSQRKRVYYa-EGNRGLNtdPSGSFHSQIIDLVGATNVAq 226  Chlorobium tep...
Feature 1                    #                                                                   
NP_616138    270 e------agVKERGTISMEDLItQNPDIIVTRDSKT-----KEELLTNDq----YHDISAVKTGKIYVNPKGVY-LWGVR 333  Methanosarcina...
NP_603212    207 d------itTGNWSKVTMEEIIkWNPDIIILSNFDKi---lPEDIYNNKfegqdWSKINAVKNKKVFKAPIGIY-RWDAP 276  Fusobacterium ...
ZP_00011857  262 --------eVGGSRTVTLEQLLvWNPDVILLGNFDTa---mPADLYGDPr----LQGIAAIKQRRVYRVPLGGY-RWDPP 325  Rhodopseudomon...
ZP_00098239  242 eam---tkaNKESLTYTLEDLLkWNPDVMFVASAAE-----KKDVLADAr----LGEITAVKNGAIYIVPRIAH-VWGNR 308  Desulfitobacte...
ZP_00103839  259 ---------KGTTGDVNVEVVLaADPDVIITQGGNG-----TAGFLQDNr----IQNLTAIKNKAVYECPIAAF-WWDRP 319  Desulfitobacte...
P44206       238 a-------tIKGFKQVSLENVLeWNPAVILVQDRYPd----VVPQILNDq---gWANIQALKDKKVFLMPEYAK-AWGYP 302  Haemophilus in...
ZP_00078086  262 anpqmesanTSEEIQVSLEQIYqWNPDVIITKTAKG-----RDEILSKD-----AWKDIAAVKNKRVYASTKYE-MLDRT 330  Methanosarcina...
ZP_00092341  931 vv----nlpDEGMSSVSLEQLYlWQPDLILTWTPAAdqsttWKAVVENPl----WQPVDAVKQGKVLQIPWIPFsWFDRP 1002 Azotobacter vi...
ZP_00090854  222 ca----dkgFATSREVDFETLLeLDPDVVVARNPDS-----AARLRGEPr----WQLLRAVREGRVYGIPELPFnWFDRP 288  Azotobacter vi...
NP_662637    227 vn----rlsGKGMSAVSMEQVLqWNPDEVIVWTGMGpsmttYRAIAADPl----WQRVPAVRKGRIHQIPFLPFgWFDRP 298  Chlorobium tep...
Feature 1                                  
NP_616138    334 SAETAMQt-lWSAKITHPELFEDLDM 358  Methanosarcina acetivorans C2A
NP_603212    277 SAETPLMi-kWIAKVANPELFNDYNM 301  Fusobacterium nucleatum subsp. nucleatum ATCC 25586
ZP_00011857  326 SHESALAw-tWLAKLLHPDRLTTDLR 350  Rhodopseudomonas palustris
ZP_00098239  309 TTEQPLTi-mWAMNKLYPEIVTDSQL 333  Desulfitobacterium hafniense
ZP_00103839  320 SPEAPLGf-mWLAQTLYPEYTKDIDL 344  Desulfitobacterium hafniense
P44206       303 MPEALALgevWLAKALYPQRFQDVDL 328  Haemophilus influenzae
ZP_00078086  331 QSLMGLL---WTAKVLYPDKVKIDLD 353  Methanosarcina barkeri
ZP_00092341 1003 PGSNRILgafWLARTLYPEVFPLDLT 1028 Azotobacter vinelandii
ZP_00090854  289 PSFMRALgahWLARLLHPRRFDEDIR 314  Azotobacter vinelandii
NP_662637    299 PGTNRILgalWLAQLVYPEVYHIDLE 324  Chlorobium tepidum TLS

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