Conserved Protein Domain Family
TroA_d

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cd01141: TroA_d 
Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. A typical TroA protein is comprised of two globular subdomains connected by a single helix and can bind their ligands in the cleft between these domains.
Statistics
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PSSM-Id: 238561
Aligned: 14 rows
Threshold Bit Score: 132.93
Created: 10-Jan-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative ligand
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to PsaA from Streptococcus pneumoniae
  • Citation:PMID 9862808

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                #                      
NP_810865    87 GQVLKGDA-KRIVAMSSTHIAMLDAIGev--rCITGVSGIdy----------iSNPDIQarrdsi---gdvgyeGNINYE 150 Bacteroides thet...
NP_558561   149 AVVIKYPM-ERAVYMSSTHVAMAYRLYke--aDNAGVLKSivgimw-gkeydwYLPEVAemlkngs-iadvgpaYSPNYE 223 Pyrobaculum aero...
NP_661314   102 GYTVIRTPvKRIAVFSTTHIGFLDMLGrs--dGIIGVSRPef----------vNTPAVRsrirsga-ikaigmpFSPDVE 168 Chlorobium tepid...
NP_349055   183 NETVITYPvNNVLVSSATQGSLLRPLDei--kSIKTVTLKeneweideiksllNDNKITyig----------dtTSPDFE 250 Clostridium acet...
Q58282      109 GKIIKVPV-KRIVTDFYCPIISAADILnayhhTIVGAPKYav----------eKSPKLKelfdegkvvdigspsKGVNYE 177 Methanocaldococc...
NP_487978    45 QELAKLSA-KRVVTLSSLTTDIIFQLDk---tKLVGISGSsl---------fkNDPRFQdipri------segqSPPNLE 105 Nostoc sp. PCC 7120
NP_487283    37 ASQPIKLA-TRVVALTPLGADLIYNLDk---sKLLAVPAGrytdvv-akakfaQLPRIGg-------------rGNINLE 98  Nostoc sp. PCC 7120
NP_599906    58 SITLESKP-ERIAVLTPEAASLVLPITga--dRVVMTAEMdta--------deETAALAsqvey-----qvkngGSLDPE 121 Corynebacterium ...
NP_246015    14 ALTPFAYA-QKIVTLTPDVADIVVALDaq--dKIVGRDQTt------------MNPALEkvav-------igihRKLAVE 71  Pasteurella mult...
ZP_00117203  40 NVSISVNP-KRILSLTPSITELVYTFSdt--sRLIGRSVWcdyp-----agvkVIPAVNn--------------YPLDIE 97  Cytophaga hutchi...
Feature 1                                                                                       
NP_810865   151 LLLSlDPDLVLLYGVNgas---ameSKLEELDi--pFMYVGdyl-----eesPLGKAEWMVVLSEVTg------KREKGE 214 Bacteroides thet...
NP_558561   224 LIAKlKPDVVFVYFYPgpygtesviKKLEQLGi--pYVVINefq-----egdPLGRAEWIKFIAAFYn------LTSAAV 290 Pyrobaculum aero...
NP_661314   169 ALLNlEPDLVIAPALPaark--tdyQALVQAGi--pVLVVAewl-----epsPLGRAEWIKLFGALVg------KEKLAR 233 Chlorobium tepid...
NP_349055   251 KISSsKPDVAILYGGSygln--nmmKKFDELH----INYTSdney---leedPLGRLEWIKFLSAFYd------KEDKAE 315 Clostridium acet...
Q58282      178 LIVNlTPDIVFLGDWKsed---vveEKLKELGvtvsRFYTYqe-------ptYMGRVEWIKFAAAFWgs----nAYKKAD 243 Methanocaldococc...
NP_487978   106 KIVAlKPDLVIGAEGFsnq----piQRLQQLGi--pTLLTQi---------nTWKSLEEITAKLAQLidvnpqpLLERYR 170 Nostoc sp. PCC 7120
NP_487283    99 KIVAlKPDLVIGSETFqgq----ilNKLKELG----INTVShe-------trSWQDLKTLTEDLAGRigadpkpILDKYQ 163 Nostoc sp. PCC 7120
NP_599906   122 QVVAaDPDLVIVSARFdteq--gtiDILEGLN----VPVVNfd-------sdAWGDIDAITKHLEIVgel--vgEEDKAA 186 Corynebacterium ...
NP_246015    72 PIVQsKPDLVLGSYMAmpa---tifDNLTQLG----VKAVNv---------lPEDHIDAFGKAIREVgql--igKQDKAN 133 Pasteurella mult...
ZP_00117203  98 GVVRlKPDLILVKQGMisv---qelDKLEQLHl---AVYVQkydllneiyasTKTLVEITKGDSATYkh---wlTSMQSD 168 Cytophaga hutchi...
Feature 1                                                                                       
NP_810865   215 KAFAAIPVRYNALKKKVads-tlgTPSVMLNvp-------------ygDSWFMPSTQSYVArl--------itDAGGRYI 272 Bacteroides thet...
NP_558561   291 GIFNGIENKWRGLVSLVad---ldRPRVAWFii--------------yGGVLYPAGAGAREli---------rLAGGRYA 344 Pyrobaculum aero...
NP_661314   234 ERFAAIESSYLKIAALSrnl--pnRPTVLTGlp-------------vkDAWYVPTGGSYVAam--------lrDAGASYH 290 Chlorobium tepid...
NP_349055   316 NYFNQQVSKVMATENKVss---lkKPKVAFGmv-------------dnGKVYIPAKNSYAAkm--------vdMAGGDYI 371 Clostridium acet...
Q58282      244 KWFENVVKVRENILKKVqnv--tnEPTVVIFsws-----------ktkNMPGIYGNDSYYSkmi-------aeFKGKNVF 303 Methanocaldococc...
NP_487978   171 SFLGDKPGTNTSTLVLVs-----sQPILAPNk----------------NSWAGDLLEKFQVknlaaelqgkspIAGYVTL 229 Nostoc sp. PCC 7120
NP_487283   164 SFIAQIPENGKSVLVLVs-----tQPTLSPNr----------------NSWSGDLLEKFQYknvtgdlqantrFQGYLTL 222 Nostoc sp. PCC 7120
NP_599906   187 EAIAEIDANRIDIDKPAt------SPTVLTLmqrgprqmvmpesamlnGLIREAGGTPVVDsl---------gAVGTITA 251 Corynebacterium ...
NP_246015   134 QVASQWEAGIQALPSTGkrylltyDGRVVAGkht-----------aadELIRRAGGVNAAVd-----------VEGIKPL 191 Pasteurella mult...
ZP_00117203 169 TMHTSVQHAKTCLAVTSv------SPIYVFGktt-----------fvsELIEQAGGKNCVEti---------qSAYPTVD 222 Cytophaga hutchi...
Feature 1          
NP_810865   273 YQK 275 Bacteroides thetaiotaomicron VPI-5482
NP_558561   345 YAN 347 Pyrobaculum aerophilum str. IM2
NP_661314   291 WRD 293 Chlorobium tepidum TLS
NP_349055   372 FKD 374 Clostridium acetobutylicum
Q58282      304 DDY 306 Methanocaldococcus jannaschii
NP_487978   230 SAE 232 Nostoc sp. PCC 7120
NP_487283   223 SQE 225 Nostoc sp. PCC 7120
NP_599906   252 DPE 254 Corynebacterium glutamicum ATCC 13032
NP_246015   192 NRE 194 Pasteurella multocida
ZP_00117203 223 VEY 225 Cytophaga hutchinsonii

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