1P9R,5IT5,4KSS,6GEB,5TSG,4PHT,3JVV


Conserved Protein Domain Family
PulE-GspE-like

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cd01129: PulE-GspE-like 
Click on image for an interactive view with Cn3D
PulE-GspE family
PulE and General secretory pathway protein GspE are ATPases of the type II secretory pathway, the main terminal branch of the general secretory pathway (GSP). PulE is a cytoplasmic protein of the GSP, which contains an ATP binding site and a tetracysteine motif. This subgroup also includes PilB, a type IV pilus assembly ATPase, DotB, an ATPase of the type IVb secretion system, also known as the dot/icm system, Escherichia coli IncI plasmid-encoded conjugative transfer ATPase TraJ, and HofB.
Statistics
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PSSM-Id: 410873
Aligned: 76 rows
Threshold Bit Score: 170.744
Created: 17-Aug-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
ATP bindinghexamer
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Structure:5IT5; Thermus thermophilus PilF with bound ATP, contacts at 4A
    View structure with Cn3D
  • Comment:contains Walker A and Walker B motifs

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                          # ######                        #                             
1P9R_A       157 DNFRRLIKrphGIILVTGPTGSGKSTTLYAGLQELNss-eRNILTVEDPIEFdidGIGQTQVNPrvdxtFARGLRAILRQ 235 Vibrio cholerae
5IT5_F       127 ERFKEVISkpyGIFLITGPTGSGKSFTTFSILKRIAtp-dKNTQTIEDPVEYeipGINQTQVNPqagltFARALRAFLRQ 205 Thermus thermop...
NP_268280    121 QELENYDCk-rGLHLFAGPVGSGKTSLMFDLARRHFt--dLQVINIEEPVELidsDFIQLQVNEvignsYDELIKLSLRH 197 Lactococcus lac...
EFU15658     127 NEIEASCQk-rGLYLFSGPVGSGKTTTMYRMAKQRSg--eQQVIAIEDPVEIeekQFLQLQTNEkiqltYEALIKVCLRH 203 Enterococcus fa...
ABD99234     123 YTLQKACIk-nGLIVFSGPMGSGKTTTMYNLARKLAn--eKHVMSIEDPIEIyepNFLQLQVNNkaqmsYSELLKVALRH 199 Lactobacillus s...
EHN59275     123 DQLEKAIPq-qGLVVVAGPTGSGKTSTIHQLLNKQSd--rKMILTIEDPVEIrdeKIVQLQVNNeanmsYLDLIKVALRH 199 Oenococcus kita...
YP_500155    119 NDFKHLMNkkqGLLLFSGPTGSGKSTLMYQMVSYANkalnLNVISIEDPVEMqipGIVQINVNDkaginYVNSFKAILRC 198 Staphylococcus ...
Q9K919       128 QQLISLMTrtqGLILLTGATGSGKTTTLYAMLQKALhmqnLHIVTIEDPIEQlnpAFTQFEMNEkaqltYEVGLKAALRH 207 Bacillus halodu...
YP_003027904 122 ERLAEEIKg-rGLYLFSGPVGSGKTTLMYHLARLKFp--dKQILTIEDPVEIkqeDMLQLQLNEaigatYDNLIKLSLRH 198 Streptococcus s...
YP_193634    123 IKLEKLATk-rGLIVTSGPTGSGKTTTMYEIAKKLSe--nRIVMTIEDPVEVyesSFLQSQVNNeagidYQSLLKAALRH 199 Lactobacillus a...
Feature 1                                                                          #             
1P9R_A       236 DPDVVXVGEIRDLETAQIAVQASLTGHLVXSTLHTNtAVGAVTRLRDXgiEPFLISSSLLGVLAQRLVrtlcpdckepye 315 Vibrio cholerae
5IT5_F       206 DPDIIMVGEIRDSETAKIATEAALTGHLVIATLHTNdAAQAITRLDEMgvEPFNISAALIGVLSQRLVrrvcehckvevk 285 Thermus thermop...
NP_268280    198 RPDLLIVGEIRDKLTAQAVLRASLTGYTVFSTVHASsVRGVIQRLSELglSHWEIKNALSSVVYQRLIagkgvldiakne 277 Lactococcus lac...
EFU15658     204 HPDILIIGEIRDGETAQAVIRAALTGHTIFATIHARnLLGVQRRLIELggPEHELAECLQGIIYQQILtttinkeqvagi 283 Enterococcus fa...
ABD99234     200 HPDIFLIGEIRDNMTAKVAINAALSGHLILTTVHARnVYGVYQRLKNLgiSDEELQQTMQVISYQRLIpti--------- 270 Lactobacillus s...
EHN59275     200 HPDILLIGEIRDAQTAQAAVQASLSGHLVFSTLHANsSLGVISRLLEMnvNPVLLKDVMRLAVYQRLLprn--------- 270 Oenococcus kita...
YP_500155    199 DPDVILIGEIRDKDVAKCVIQASLSGHLVLTTLHATdCKGAILRLLEMgiSVQELIQATNLIINQRLVtti--------- 269 Staphylococcus ...
Q9K919       208 DPDVIMIGEIRDQTTAVYAVRAALTGHLVLATIHSAnARGTITRLCEMgvALHDLREVVVAIIAQELIsrkcplclssd- 286 Bacillus halodu...
YP_003027904 199 RPDLLIIGEIRDAETARAVIRASLTGATVFSTVHARsISGVYARMLELgvGPEELNNALQGIAYQRLIggggvvdfakgn 278 Streptococcus s...
YP_193634    200 RPDILIIGEIRDQGTARLSVDAALSGHLVLATVHAKsTFQTISRLEGLgiSNDELKNCLTAISYQRLMpsdnevrclmd- 278 Lactobacillus a...
Feature 1                                             # #        
1P9R_A       316 adkeqrklfds--kkkeplilyratgcpkcnhkgyrGRTGIHELLLVD 361 Vibrio cholerae
5IT5_F       286 pdpetlrrlglseaeiqgarlykgmgcercggtgykGRYAIHELLVVD 333 Thermus thermophilus
NP_268280    278 f-----------------------eswssenwnkkiDQLLTNGYLTPT 302 Lactococcus lactis subsp. lactis Il1403
EFU15658     284 lydy----------------fffkeaviksswqknlRKAWAYGFITEK 315 Enterococcus faecalis TX1342
ABD99234     271 ----------------------------------dgGAKVLFDQIEGK 284 Lactobacillus salivarius UCC118
EHN59275     271 ----------------------------------dgHQAALADWQFFT 284 Oenococcus kitaharae DSM 17330
YP_500155    270 ----------------------------------kqQRQLVCEILSQQ 283 Staphylococcus aureus subsp. aureus NCTC 8325
Q9K919       287 -------------------------cspyctwlnnrKRAAIFDILEGK 309 Bacillus halodurans C-125
YP_003027904 279 yqnhsa-------------dqwnaqidrlfaaghisLRQAETEKITLG 313 Streptococcus suis BM407
YP_193634    279 -------------------------iasgeslkselNKSIRSDFVSWQ 301 Lactobacillus acidophilus NCFM

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