1PVO,3L0O,2HT1,3ICE,1PV4,5JJI,1PV4


Conserved Protein Domain Family
rho_factor_C
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cd01128: rho_factor_C 
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C-terminal ATP binding domain of transcription termination factor rho
Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal oligonucleotide/oligosaccharide binding fold (OB-fold) domain which binds cysteine-rich nucleotides, and a C-terminal ATP binding domain. This alignment is of the C-terminal ATP binding domain.
Links
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Statistics
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PSSM-Id: 410872
Aligned: 36 rows
Threshold Bit Score: 417.762
Created: 17-Aug-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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ATP bindinghexamer
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Structure:1PVO; Escherichia coli Rho factor with bound AMP, contacts at 4A
  • Comment:contains Walker A and Walker B motifs
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                              ######                                                 
1PVO_A    156 DLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLV------------ 223 Escherichia coli
Q9ZLS9    175 KVTGRMLDLFSPVGKGQRALIVAPPRTGKTELMKELAQGITSNHPEVELIILLVDERPEEVTDMQRSV------------ 242 Helicobacter pylor...
P52153    163 GLSLRVVDLLVPIGRGQRALIVAPPKAGKTTLLKKIANSITKNYPDVTVMVLLVDERPEEVTDFRESVq----------- 231 Deinococcus radiod...
NP_866448 246 ELSTRVVDLFTPIGFGQRGLIVSPPRAGKTMLMQSLARGVLNNYPDAYVVVLLIDERPEEVTDMEREIqs---------- 315 Pirellula sp. 1
ADP98621   41 QLTVRAMDLITPIGMGQRGLIVAPPGSGKSTVLKHICQAVGKAYPEIKLYALLIDERPEEVTDFRRSV------------ 108 marine bacterium HP15
C9RLJ9    392 EYSTRIMDLFSPIGKGQRSIILAPPRTGKTVLLQNVTRAIAKNHPEIILITLLIDERPEEVTEMRDIItdikekaaekgi 471 Fibrobacter succin...
C1A5H8    474 ELTRRAIDLIAPIGYGQRALIVAPARAGKTTLLQAIVEGVSINHPEAVLLVLLVDERPEEVSEMITWG------------ 541 Gemmatimonas auran...
B2UR37    213 SAAMRVLDLMTPFGKGQRGLIVAPPRGGKTVLLKTIARSIRANYPEVELIVLLLDERPEEVTDFEETV------------ 280 Akkermansia mucini...
C7LJY3     98 TLSTRIVDFFSPLGKGQRGIIVAPPKTGKTTLLKEIANTIAYNHPEVYLIILLIDERPEEVTDMQRNV------------ 165 Candidatus Sulcia ...
YP_446441 110 DESMRVLDLVAPLGKGQRALIVSPPRAGKTVLLKDIAAGVTENHPEVELVSLLVDERPEEVTDFRRTT------------ 177 Salinibacter ruber

Feature 1                                                                                     
1PVO_A    224 --KGEVVASTFDePASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPa----------SGKVLTGGVDA 291 Escherichia coli
Q9ZLS9    243 --KGQVFSSTFDlPANNHIRIAELVLERAKRRVEMGKDVVVLLDSITRLARAYNAVTPs----------SGKVLSGGVDA 310 Helicobacter pylor...
P52153    232 --GAQVIASTFDePPQHHVRVAEFVHERARRIVEEGGHVVILLDSITRLARANNLVTPp----------TGRTLSGGLDS 299 Deinococcus radiod...
NP_866448 316 -pQCEVISSTFDePPARHIQVAQMVVEKAKRMVESGTDVVIFLDSITRLARAFNSDSDs---------aTGKLLTGGLDA 385 Pirellula sp. 1
ADP98621  109 --PAEVHASSSDeSYAHHVRVADELLDIARQQAGEGHNVMIVIDSLTRLSRVHNAERKs----------SGRTMSGGMDA 176 marine bacterium HP15
C9RLJ9    472 eiKAEVVASTFDePPEHHTRVANMVLEKAKRLVESQKDVVILLDSITRFARANNVVIPhsgkilsggvdANAMQFPKKFF 551 Fibrobacter succin...
C1A5H8    542 --YGEVVASSFDmPPKRHVEVAEMTLERARRLVEQGKDVVIVLDSITRLARAHNTVDRg----------TGRTMSGGLDA 609 Gemmatimonas auran...
B2UR37    281 --DAPVFASTFDePSRRHAQVSDLVIERAKRLVEMGRDVVILLDSLTRLARGYNANQT-----------GGRIMSGGLGS 347 Akkermansia mucini...
C7LJY3    166 --NGEVVYSTFDePAEKHVKVANIVLQKAKRMVECGHDVVILLDSITRLARAYNTVSPt----------SGKILSGGVDS 233 Candidatus Sulcia ...
YP_446441 178 --EAQVFASSNDrGEDNHVRVSTLAMEHAKRLVETGKDVVVLLDSLTRLGRTFNLWVDg----------SGRTLSGGLDA 245 Salinibacter ruber

Feature 1                                                                            #        
1PVO_A    292 NALHRPKRFFGAARNVEEGGSLTIIATALId--------TGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYnRS 363 Escherichia coli
Q9ZLS9    311 NALHRPKRFFGAARNIEEGGSLTIIATALIe--------TGSRMDEVIFEEFKGTGNSEIVLARNIADRRIYPAFDIlKS 382 Helicobacter pylor...
P52153    300 NALHWPKRFLGAARNIREGGSLTILATALVe--------TGSRMDDVIFEEFKGTGNAELVLSRRLEERRIFPALDIlKS 371 Deinococcus radiod...
NP_866448 386 GAMQKPKSIFGSARKVEEGGSLTILATALVd--------TGSRMDDVIFEEFKGTGNLEIVLDQDLVARRVWPAIDLtRS 457 Pirellula sp. 1
ADP98621  177 RAMEIPRRLFGAARNIENGGSLTILATVLVd--------TGSRMDQVIFEEFKGTGNMELVLSRDVANQRIFPALDIsKS 248 marine bacterium HP15
C9RLJ9    552 GAARKIQDKIRTVKNEDGTISEEVQKNGSLtiigtalieTGSRMDEVIFEEFKGTGNMELVLDRRIAEKRIWPAIDVfKS 631 Fibrobacter succin...
C1A5H8    610 TAMQKPKAFFGSARMIAPQHGGGSLTIIATal-----veTGSRMDDVIFEEFKGTGNCEIKLDRSLADRRIFPAFDIaTS 684 Gemmatimonas auran...
B2UR37    348 NALEKPRKFFSAARNVEEGGSLTIIATCLVd--------TESRMDEVIFEEFKGTGNLEIRLDRELSERRIYPAISLsQS 419 Akkermansia mucini...
C7LJY3    234 NALQKPKRFFGAARNIEYGGSLSIIATAIIe--------TGSKMDEVIFEEFKGTGNMELQLDRKIANKRIFPAIDLnAS 305 Candidatus Sulcia ...
YP_446441 246 EALKVPRQIFGSARNIEGGGSLTIIATALVd--------TGSRMDEVIFEEFKGTGNSEIVLDREMADKRIFPAVNLrES 317 Salinibacter ruber

Feature 1                                                 
1PVO_A    364 GTRKEELLTTQEELQKMWILRKIIhpm---geiDAMEFLINKLA 404 Escherichia coli
Q9ZLS9    383 GTRKDNILLGKDRLTKVWVLRNVMqqm---ddiEALSFVYSKMQ 423 Helicobacter pylori J99
P52153    372 GTRREELLLQPEVLKKMWLLRKVIsdm---dpaDAMEMLLGRMG 412 Deinococcus radiodurans R1
NP_866448 458 GTRREEMLLDQEEHRRIETLRRDLaeh---spvDSMTELIKRMR 498 Pirellula sp. 1
ADP98621  249 STRREELLLDPKDLDKIRALRRALggl---kplEGTKKLVELLE 289 marine bacterium HP15
C9RLJ9    632 GTRKEERLLTLLEQNAAWNFRRGSqnetetgimENLLKLMSKLK 675 Fibrobacter succinogenes subsp. succinogenes S85
C1A5H8    685 GTRREEKLYRPDQLEKVHLLRRGLhql---ppqAGMEWLIKRIA 725 Gemmatimonas aurantiaca T-27
B2UR37    420 GTRNDDRLYNEQEFVKIMQLRRQLamk---pgwEGLQTLLQNIS 460 Akkermansia muciniphila ATCC BAA-835
C7LJY3    306 STRKEEFLLTKYNLNKMFLIRKLLaem---tsvEAIDFIKTRLM 346 Candidatus Sulcia muelleri SMDSEM
YP_446441 318 GTRNEERLLGEVRRKKHNQLFRALnsr---apiEAMQALLRHLR 358 Salinibacter ruber

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