1GKI,1GL6,1E9R,2IUT,4AG6


Conserved Protein Domain Family
TrwB_TraG_TraD_VirD4
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cd01127: TrwB_TraG_TraD_VirD4 
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TrwB/TraG/TraD/VirD4 family of bacterial conjugation proteins
The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion (T4S) systems, versatile bacterial secretion systems mediating transport of protein and/or DNA. They are present in gram-negative and gram-positive bacteria, as well as archaea. They form hexameric rings and belong to the RecA-like NTPases superfamily, which also includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases.
Links
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Statistics
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PSSM-Id: 410871
Aligned: 140 rows
Threshold Bit Score: 43.3622
Created: 17-Aug-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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ATP bindinghexamer
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Comment:contains Walker A and Walker B motifs
  • Structure:1GKI; Escherichia coli TrwB bound to MgADP
    - View structure with Cn3D
  • Comment:two of the arginine residues are involved in the active site of a different monomer
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                #######                                                                 
1GKI_A        55 HLLVNGATGTGKSVLLRELAYTGLlrgdRMVIVDPNGDmlskfgrdkdiilnpydqrtkgwsffneirndydwqryalsv 134 Escherichia coli
WP_095398196 239 NIVVMGIAGVGKSTAVKHIALSEYmkgtKIIFVDPESEykeltlrlngdwinagggaggkinplqirpaprddddeehpl 318 Paenibacillus s...
CCY58272     236 NVVFIGNSGVGKSTKMKDMLTDEYmmgsKVLIIDPEDEykeqskyfngawinaaggihgkinplqiypipvddedeyyad 315 Clostridium sp....
CDE10275     242 NIIIEGSSGSGKSFLAKKIMLNEYlngtKIWIIDPESEyrpickllggkwidcsggegefvgrinplqinpvptagfede 321 Clostridium sp....
CCY74588     242 NITIVGGSGSGKSTAIKHIIASEYargtKIIVIDPESEykdmcynplfegnwidvaggkgglinplqirpvppdtddena 321 Eubacterium sp....
WP_023355288 233 NMVVLGINGTGKSTAVKHIILNEFmlgkRIIIIDPEREykdmckacggdwinaaggkgkinplqikvsskdtqdddsyed 312 Catonella morbi
WP_092560209 244 DILVTGIKGQGKSTAVKHIALNEYmlgtRIIFIDPEAEygeecrklqgdwinagggiggrinplqiaaipreendkvytd 323 Clostridium pop...
SEM99993     239 NFAVLGKSGTGKSTFIKHLIEIEYmrgtRILIIDPEGEyakittmlggqvlnatggkgarsnplefkaapklnkddikdd 318 Hydrogenoanaero...
KUK47548     131 NMVVLGNAGGGKSTFMKLDILMEHmagtKVIIIDPEDEyralsaridgqwidagnsgatvinplevwateavaddeeead 210 Actinobacteria ...
CDB95462     300 NFTVMGMPGKGKSFSVKSILLGEWmrgtRIYIIDPEREyvqmveeemegevlkvganskgsminplqirtvsssskdekn 379 Firmicutes bact...

Feature 1                                                                                        
1GKI_A       135 vprgktdeaeewasygrlllretakklaligt--------------------psmrelfhwttiatfddlrgflegtlae 194 Escherichia coli
WP_095398196 319 ykdegngmsdmalhlknleiffnlyipdltmmqkavl-----------kqclielyhqfqitwttditklnsvdfptfsd 387 Paenibacillus s...
CCY58272     316 egygmgplalylkhletffnlysesiddylmaylkqv----------lielykekgitfdtdvtnlkneefpiieelvmk 385 Clostridium sp....
CDE10275     322 eedseynttksalalhldflttffklyypeitslemsll-------netleelyksfginydtdisnfktiqfpimqdly 394 Clostridium sp....
CCY74588     322 epqendsigdlaihlktlqtffrlyipsmddrlralld---------qalvelyhkfgiswdtdvsgysanqfptltdly 392 Eubacterium sp....
WP_023355288 313 needteeeklselaihlknlevffslyinsltdtklaiikr---slielykifnidwdtdnsklkaedypimedlynyil 389 Catonella morbi
WP_092560209 324 egngmgdlalyikhleiffslylpsltdmdravlkdsli-------elynqfriywttdisklcpedfpilsdlynllks 396 Clostridium pop...
SEM99993     319 ddkkadlykdsigalalhlktlevfyrlykpsltdaqsdl----lkqvlielylkfgitwntdvtklkstdypiqsdlle 394 Hydrogenoanaero...
KUK47548     211 lgrfnpvarhleflktffalqlpddytareileievr-----------elyrahgltldltsvshmtawptlsdlrtqia 279 Actinobacteria ...
CDB95462     380 pdeedtanlashlktvetffdlyleditasqkallkdmtikayakygitfesdishltnndypvmkdiydliefeitkld 459 Firmicutes bact...

Feature 1                                                                                        
1GKI_A       195 slfagsneaskaltsarfvlsdklpehvtmpdgdfsirswledpngGNLFITWredmgpa---lrplisAWVDVVCTSil 271 Escherichia coli
WP_095398196 388 lhnlisakeqatqddiykelslllhdiahggdsflwnshstiqtrsRCICLDThslqntsdnikrtqyfNLLSWCWEQms 467 Paenibacillus s...
CCY58272     386 lkekeeqtkgmeekdiyrrlsillwdmaygsdaflfngytsiaadnAYTCISTsglndasnrikraqyfNLLTWAWHVis 465 Clostridium sp....
CDE10275     395 slleekvkgksnhqkeyeelravlrqmaignnseifnghttiqfdsDFICLDVyslqgasenvkrcqyfNILRYCQDQaf 474 Clostridium sp....
CCY74588     393 nliaekaklkdnntvyyedlktylegaangadhrlwngyttinptsGFIVLDTksliqmsgtvlaaqyfNVLSWCWEQit 472 Eubacterium sp....
WP_023355288 390 seaermkdegddqfkeyediarlfedvakggdsflwnghttlnsdaQFVVLDTkdlqdsserikgteyyLLSTWMWAEms 469 Catonella morbi
WP_092560209 397 kadkeeavrkdgdvnyykklslllkdaaegadsilwngkttlhaesRCVCLDTsalqgssdnvkraqyfLINSWTWQQms 476 Clostridium pop...
SEM99993     395 llkekakdkaspyksdydqlvlyftdiaqggdsfiwnghstinsnsNVICFDTnelqnvspnikgaqyyNLTTWCWNEmt 474 Hydrogenoanaero...
KUK47548     280 srvhaaaepsagereayagldlffknltegsrglmwdgqtnvtlgsDVLVFSThslqeadsstyaaqyhLITQLMWREiq 359 Actinobacteria ...
CDB95462     460 mkkkrgenvstveyndyvqlrglmkdiavggdsfiwngettihsdsKVVALDTsgfaegneklkkiqyfNVLTWVWEQas 539 Firmicutes bact...

Feature 1                                               #                                        
1GKI_A       272 slpeepkrrLWLFIDELASle------kLASLADALTKGRKAGLRVVAGLQSTSQlddvygvkEAQTLRASFRSLVVLGG 345 Escherichia coli
WP_095398196 468 qd---rnerVLLICDESYLmidpnvpqsLVFLRNVEKRARKYEASLAIISHSVVDflapevkmYGQALLDIPCIKILMGT 544 Paenibacillus s...
CCY58272     466 rn---rsekVILVCDEAYLlvdpeipqsLIFLRNSMKRARKYEAAIWVITQNTVDflneevkmYGQELLDNPTFKILMGI 542 Clostridium sp....
CDE10275     475 kd---rrerDLVFCDEAYLlidkkvpqsIEFMRNFCKRARKYESGLVTITQSLVDflapevkqYGQALLDNSTYKFFFGI 551 Clostridium sp....
CCY74588     473 hd---rkerIMLVADECWTmidprcpqsLEFLKNAEKRARKYEGSIIVGTQSTNDfldpevkfYGQSVLDLPTFKLLFSM 549 Eubacterium sp....
WP_023355288 470 rd---rtekVVGVFDEAYLlidkrvpqtLAFLRNASKRCRKYEGSMIIISHSVVDfldesvkmYGQALLDLPTYKFIFGC 546 Catonella morbi
WP_092560209 477 rd---rterVMTFYDEAYLmidpnipqsLVFLRNCMKRSRKYEAAMVIISHSVNDflspevkmYGQALVDEPCYKIMFGT 553 Clostridium pop...
SEM99993     475 kn---pnerVLLICDEAHLmidkrvpeaLYFLKSASKRCRKFTSGIVVASQSVVDfladeikaAGQALLDQPCYKVLFGT 551 Hydrogenoanaero...
KUK47548     360 anr-dtgehLLVVMDEAHLaidpktpatLEAIKNFAKRIRKYGGALMVATQNVSDfldpaierQGRAVLDNASTKVVFGA 438 Actinobacteria ...
CDB95462     540 qn---reerCIIVADEAYMmidqrvptaLIHMRNMAKRGRKYNVSIMTISHSVVDflapaikqYGQELIGTSCYKMFFGC 616 Firmicutes bact...

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