1Q05


Conserved Protein Domain Family
HTH_CueR

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cd01108: HTH_CueR 
Click on image for an interactive view with Cn3D
Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators
Helix-turn-helix (HTH) transcription regulators CueR and ActP, copper efflux regulators. In Bacillus subtilis, copper induced CueR regulates the copZA operon, preventing copper toxicity. In Rhizobium leguminosarum, ActP controls copper homeostasis; it detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. These proteins are comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their conserved N-terminal domains contain winged HTH motifs that mediate DNA binding, while the C-terminal domains have two conserved cysteines that define a monovalent copper ion binding site. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements.
Statistics
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PSSM-Id: 133383
View PSSM: cd01108
Aligned: 30 rows
Threshold Bit Score: 192.006
Threshold Setting Gi: 88940005
Created: 30-Apr-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding residues [nucleic acid binding site]
Evidence:
  • Comment:Based on sequence similarity to BmrR and the structure of Bacillus subtilis BmrR bound to DNA (1EXI).

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        ###             #                ###                                           
1Q05_B        1 MNISDVAKITGLTSKAIRFYEEKGLVtpPMRSENGYRTYTQQHLNELTLLRQARQVGFNLEESGELVNLFndPQRHSADV 80  Escherichia coli
ZP_00733040   1 MNITEVAQKTQLTQKSIRFYEEKGLItpPTRGVNGYRQYNASHIEELTLIHQARQVGFSLPVCKELLELYknPHRRSADV 80  Actinobacillus s...
CAC21398     13 MNISQIAKLTSLTAKSIRLYEEKGLIipPLRSESGYRTYTQQHVDDLLLIARCRRVGFSLDECKAMLTLAndPNRTSAAV 92  Vibrio cholerae O1
BAC96647      1 MNIGAIAKLTGLSSKSIRMYEEKGIIspPLRSDAGYREYGQKHIVELNLVSRAKNAGFSLQECKEFVQLAqnPNRKSSEV 80  Vibrio vulnificu...
ZP_00992545   1 MNISEAAKLTNLSTKSIRLYEDKGVItaPFRSENGYRSYDKKQIKELGIVAKARSAGFSLDECRALVELAdnPCRESADV 80  Vibrio splendidu...
ZP_00998351   1 MNIGRAAKETGLTVKTIRYYEEIGLId-ADRARNGYRDFGDRQITRLRMLAQARHLGFGLEECRQLLDLDadPARASRDV 79  Oceanicola batse...
NP_717298     1 MKIGEVAKHTGLSVKSIRYYHDIGLVc-AERNDAGYRVYRHRDIESLKFVHQCRDLGFSLEDCKLLLDLRnnDSRNAEDV 79  Shewanella oneid...
P44617        1 MNISEAAKLVGLSTKQIRDYEKMGLIkpAVRSLSGYRNYGESDLERLHFIRHSRNVGFSLHQIAQLLALQdnPKRSCREV 80  Haemophilus infl...
ZP_00135072   1 MNISQAAKHTELSAKQIRDYEKAGLLpqATRSSSGYRIYSAADLERLHFISNARKVGFSLVQISELLKLNddPHRTSREV 80  Actinobacillus p...
ZP_00132704   1 MNIGQASKATGLSIKQIRDYEKVGLLsnTSRSASGYRIYGNDTLDRLKFIAKARGVGFSLAQIGELLALQdnPHRKSCEV 80  Haemophilus somn...
Feature 1                                                      
1Q05_B       81 KRRTLEKVAEIERHIEELQSMRDQLLALAnACPGDDSADCPIIENLS 127 Escherichia coli
ZP_00733040  81 KARTMTRIAEIDTQIRQLQFMREKLMSLAqQCPGDDSENCPIINGLS 127 Actinobacillus succinogenes 130Z
CAC21398     93 RARAQEKWQEISRKLSELTMIKQQLEEWIaSCPGDQGSDCPIIEQLK 139 Vibrio cholerae O1
BAC96647     81 KEKTKEKLAEIEQKLAHLHEIKKQLEGWVsSCPGNSDSHCPIIEELT 127 Vibrio vulnificus YJ016
ZP_00992545  81 KAKALSKLEEVNKKIEDLLVIQKTLKEWVeQCPGDSNSHCPIIDSLV 127 Vibrio splendidus 12B01
ZP_00998351  80 KALALRNLAAVRDKIRQLQVLESQLETLIhECHGDDDPDCAILDSLS 126 Oceanicola batsensis HTCC2597
NP_717298    80 KQLTRNHLAYVELQISKLQNLRSQLQQMVsECQGGEQPHCTIINSLN 126 Shewanella oneidensis MR-1
P44617       81 KVLTAQHIATLNQQIEQLQKMVQKLQHWHdSCQGNDNPECLILNGLN 127 Haemophilus influenzae
ZP_00135072  81 KRLTEQHIEELQQKITDLQQMLTLLKSWSkSCCGNDSPECSILSGLK 127 Actinobacillus pleuropneumoniae serovar 1 str. 4074
ZP_00132704  81 KALANMHIEFLTQKIEELTQMKATLQAWSdACTGDNAPDCPILKGLA 127 Haemophilus somnus 2336

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