Conserved Protein Domain Family
HTH_GlnR-like

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cd01105: HTH_GlnR-like 
Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators
Helix-turn-helix (HTH) transcription regulator GlnR and related proteins, N-terminal domain. The GlnR and TnrA (also known as ScgR) proteins have been shown to regulate expression of glutamine synthetase as well as several genes involved in nitrogen metabolism. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. A typical MerR regulator is comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their conserved N-terminal domains contain predicted winged HTH motifs that mediate DNA binding, while the dissimilar C-terminal domains bind specific coactivator molecules.
Statistics
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PSSM-Id: 133380
View PSSM: cd01105
Aligned: 30 rows
Threshold Bit Score: 84.589
Threshold Setting Gi: 116490984
Created: 30-Apr-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
DNA bindingputative dimer
Feature 1:DNA binding residues [nucleic acid binding site]
Evidence:
  • Comment:Based on sequence similarity to BmrR and the structure of Bacillus subtilis BmrR bound to DNA (1EXI).

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         ###             #                  ###                                        
P37582       11 LFPIGIVMQLTELSARQIRYYEENGLIf-PARSEg--NRRLFS-FHDVDKLLEIKHLIE---QGVNMAGIKQILAkae-- 81  Bacillus subtilis
CAA05609     13 VISIGIVSELTGLSVRQIRYYEERKLIy-PQRSSr--GTRKYS-FADVERLMDIANKRE---DGVQTAEILKDMRkk--- 82  Bacillus subtilis
ZP_01359358  58 TVSIGRATELTGLKDTQIRYFEELYRQe-RDTSTpagATRSYS-LADLRRLAVFAELLK---QGYRPAQAAEVVRscahl 132 Roseiflexus sp. ...
CAB58993     12 VLPIGTVMLLTDLTARQIRYYETQGLVk-PQRNAg--NHRTYS-LNDVDELLEIRSQMA---DGFTLADVKRLKHpr--- 81  Lactobacillus rh...
YP_818199    12 ILPIGTVRELTLLTDRQIRYYEQQKLIa-PGRGKg--GQRRFS-LNDVDRLLEIRDFLD---AGDSIKDIQEIFAkqrr- 83  Leuconostoc mese...
YP_810528    12 ILPISTVRALTNLSDRQIRYYESQDLLt-TKRGKg--GQRRFS-LNDVERLIEIRMMME---SGDSLKDIHNLYEthr-- 82  Oenococcus oeni ...
ZP_01187937   7 DIPMRIVKERTGLTSRQIRYYDEMGLVf-PERTRg--NQRLFS-EEDIDRLKKIKKLLE---EGYTIAAIKEKLTpp--- 76  Halothermothrix ...
YP_321679     5 FFTSKEASKITGCTLRQLQYWREKGVVv-PVISDtgtGRSIYYsKTNLVELAAMVYWLS---VGLSFDIACETLKtlk-- 78  Anabaena variabi...
NP_487654    23 FYTSTEASEITHCSRRQLQYWREKGVIvpTVNSSg-kGRNVYYsKADLLALTVMEQLLStglNFDLCYAALQTLRkqep- 100 Nostoc sp. PCC 7120
YP_590395    20 RFSSKEVISLTSITARQLQWWDERGIVv-PAREG---HKRFYS-LDDLAEVAVLCELRQ---RGFSLQRVRKVMRflqre 91  Acidobacteria ba...
Feature 1                               
P37582       82 ---aePEQKQNEKTKKPMKHDLSD 102 Bacillus subtilis
CAA05609     83 ---eqMLKNDPQVRKKMLEGQLNA 103 Bacillus subtilis
ZP_01359358 133 -idrgATRNIADVLRREGDAITDG 155 Roseiflexus sp. RS-1
CAB58993     82 ----hREDSDAEVRKVLRDELLNQ 101 Lactobacillus rhamnosus
YP_818199    84 -kaqeKQDSEAALRRSLQKEFAQL 106 Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293
YP_810528    83 --vsnRRNEKTEFVHSLENEFLKI 104 Oenococcus oeni PSU-1
ZP_01187937  77 ---ppVKGNPEDVTLDPVFDKLNK 97  Halothermothrix orenii H 168
YP_321679    79 --dqePELFSSGTGRRFMLLSEAQ 100 Anabaena variabilis ATCC 29413
NP_487654   101 --wlfDESVPEEKMKRLMLLPTRS 122 Nostoc sp. PCC 7120
YP_590395    92 lgkrlVETVTDGSEYHLLTDGRNL 115 Acidobacteria bacterium Ellin345

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