Conserved Protein Domain Family
HTH_MlrA-CarA

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cd01104: HTH_MlrA-CarA 
Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA
Helix-turn-helix (HTH) transcription regulator MlrA (merR-like regulator A), N-terminal domain. The MlrA protein, also known as YehV, has been shown to control cell-cell aggregation by co-regulating the expression of curli and extracellular matrix production in Escherichia coli and Salmonella typhimurium. Its close homolog, CarA from Myxococcus xanthus, is involved in activation of the carotenoid biosynthesis genes by light. These proteins belong to the MerR superfamily of transcription regulators that promote expression of several stress regulon genes by reconfiguring the spacer between the -35 and -10 promoter elements. Their conserved N-terminal domains contain predicted HTH motifs that mediate DNA binding, while the dissimilar C-terminal domains bind specific coactivator molecules. Many MlrA- and CarA-like proteins in this group appear to lack the long dimerization helix seen in the N-terminal domains of typical MerR-like proteins.
Statistics
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PSSM-Id: 133379
View PSSM: cd01104
Aligned: 28 rows
Threshold Bit Score: 82.2888
Threshold Setting Gi: 113944557
Created: 30-Apr-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
DNA binding
Feature 1:DNA binding residues [nucleic acid binding site]
Evidence:
  • Comment:Based on sequence similarity to BmrR and the structure of Bacillus subtilis BmrR bound to DNA (1EXI).

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        ###             #                ###                               
P33358        4 YTIGEVALLCDINPVTLRAWQRRYGLlKPQRTDgGHRLFNDADIDRIREIKRWIdnGVQVSKVKMLLS 71  Escherichia coli
NP_967879    11 LDIDQVNQLTGLSQATLRNWEKRYGFpKPQRSEgGHRLYHVEEVQKIREVVSLCknGIKILEAIERVL 78  Bdellovibrio bacteriovorus H...
ZP_00054991  15 TPVDAIERETGLSKEVIRKWETRYGFpRPLRDEnGDRLYPNDQVFQLRLIRSLIssGMRPHQVVGRPQ 82  Magnetospirillum magnetotact...
YP_006039     7 YTIAEVEAMTGLSAEVLRQWERRYGFpKPRRTPgGHRLYSAEDVEALKTIKRWLeeGATPKAAIRRYL 74  Thermus thermophilus HB27
YP_677677     7 YDIAQLERLVGVKAHTLRKWEERYQLiSPERSAgNIRFYNDAQVIQLLNITLLLseGFKISQIAAMSS 74  Cytophaga hutchinsonii ATCC ...
CAJ47959     20 LPIAAVERETGIGKDTLRVWERRYGFpKPSRDSsGDRRYSAAQLQQLKLIRRLLdaGARPGKVVGLDQ 87  Bordetella avium 197N
ZP_00243976  22 LSIAAVERDTGLTKDTLRIWERRYGFpVPDRNAlAERFYPLDQVEKLRVIKRLLdaGHRPGQIVAQPV 89  Rubrivivax gelatinosus PM1
ZP_01312519   2 LTVQQLSQELGVSVDTLRVWERRYGFpQPQRDRrGHRRYPLDQVAQLHIVRKLQslGYRPNSLFAMSA 69  Desulfuromonas acetoxidans D...
ZP_01313691   2 LTVQQLSQELGITPDTIRVWEKRYGNpVPQRNRrGHRRYSQQQLEELRLVRNLQmlGKKPKEIFSLTP 69  Desulfuromonas acetoxidans D...
YP_678640     4 YSISDLEKLSGIKAHTIRIWEQRYNLlTPVRSDgNIRSYDDDQVRRLLNVSTLIklGIKISRISQLTD 71  Cytophaga hutchinsonii ATCC ...

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