1HKY


Conserved Protein Domain Family
APPLE_Factor_XI_like
?
cd01100: APPLE_Factor_XI_like 
Click on image for an interactive view with Cn3D
Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.
Links
?
Statistics
?
PSSM-Id: 238533
Aligned: 29 rows
Threshold Bit Score: 47.0442
Created: 10-Jan-2006
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
putative
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:putative binding site
Evidence:
  • Comment:charged pocket believed to be general protein/carbohydrate binding site in diverse family members
  • Citation:PMID 9493272
  • Comment:heparin thought to bind at sulfate ion position
  • Citation:PMID 9817840
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                          # #           #                                            
1HKY_A      9 VKLTCYQn--gVSFtgg-kaISEAk-aASSQACQELCekdAKCRFFTLAs--GKCSLFAddaalRPTKs---dGAVSGNK 79   Eimeria tenella
AAD33906  228 QISGCIQls-dVGSmt--adLEEPmeaDSVGACMERCrcdGRCTHFTFNdntRMCYLKGdk--mQLYSs---pGDRTGPK 299  Toxoplasma gondii
AAD33906  137 CDRSCFEqh-vSYEga--pdVMTAmvtSQSADCQAACaadPSCEIFTYNehdQKCTFKGrg--fSAFKergvlGVTSGPK 211  Toxoplasma gondii
AAD33906  415 DEVECVHtg-nIGSka--qtIGEVkraSSLSECRARCqaeKECSHYTYNvksGLCYPKRgk--pQFYKy---lGDMTGSR 486  Toxoplasma gondii
AAD33906  301 CDSSCFSng-vSYVddpatdVETVfeiSHPIYCQVICaanPLCTVFQWYaseAKCVVKRkg--fYKHRktgvtGVTVGPR 377  Toxoplasma gondii
AAD33906  488 CDTSCLRrg-vDYSqg--peVGKPwysTLPTDCQVACdaeDACLVFTWDsatSRCYLIGsg--fSAHRrndvdGVVSGPY 562  Toxoplasma gondii
CAB52368  417 EAPSCAVrgsrYGTi----pISTQt-vDNATLCQQQCqksSMCEAFSYDikgKVCYLHVay--aAKLKra-nyNFISGPR 488  Eimeria tenella
CAB52368  259 QAGKCTLqvdlTGDag--nhIEAPn-vSTIEQCRREClldKDCKWFTFNevtKICYHKKkv-gnIAYGl---kGDHTASR 331  Eimeria tenella
CAB52368  178 CDNSCFSqg-rKLSse---gKSLGt-aNNANICQAMCqgeDGCIGFSWNrssKECTSHPse--vGSAEd---kASVSGPR 247  Eimeria tenella
P81860      5 LDVSCFAhdknIGSrt--eqLSVVh-vASAQDCMKECqalPTCSHFTYNknsKKCHLKAga--pEFYTy---tGDMTGPR 76   Sarcocystis muris

Feature 1      
1HKY_A     80 R 80   Eimeria tenella
AAD33906  300 S 300  Toxoplasma gondii
AAD33906  212 Q 212  Toxoplasma gondii
AAD33906  487 T 487  Toxoplasma gondii
AAD33906  378 E 378  Toxoplasma gondii
AAD33906  563 T 563  Toxoplasma gondii
CAB52368  489 Q 489  Eimeria tenella
CAB52368  332 L 332  Eimeria tenella
CAB52368  248 D 248  Eimeria tenella
P81860     77 S 77   Sarcocystis muris

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap