1E0A


Conserved Protein Domain Family
CRIB_PAK_like
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cd01093: CRIB_PAK_like 
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PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the Ras-Rac pathway. This subgroup of CRIB/PBD-domains is found N-terminal of Serine/Threonine kinase domains in PAK and PAK-like proteins.
Links
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Statistics
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PSSM-Id: 238526
Aligned: 27 rows
Threshold Bit Score: 61.5171
Created: 10-Jan-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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GTPase
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:GTPase interaction site [polypeptide binding site]
Evidence:
  • Comment:contains the CRIB-motif (I-S-x-P-x-x-F-X-H-x-x-H-x-G-x-D) described in the literature
  • Comment:interacts with Cdc42 switch I and II in the presence of GMPPCP and Mg2+
  • Structure:1E0A; Cdc42-PAK complex
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        #  #  # #  #                #   #            
1E0A_B       1 XSISLPSDFEHTIHVGFDAvTGEFTGMPEQWARLLQt-sNITKSEQK 46   Norway rat
AAD09141    91 TPISGPTNFKREMHIGFDSqTGTFEGLPEEWKIMLGt-sGLSQKEIE 136  Acanthamoeba castellanii
AAD01935     9 PLISMPSNFEHRVHTGFDKrENKYVGLPLQWASIVGn-nQILKSSNR 54   fruit fly
NP_505809   34 SEISTPSNFEHRIHAGFDArSGTYTGLPKQWQALLGpprSISRPKPM 80   Caenorhabditis elegans
Q9P286       9 IEISGPSNFEHRVHTGFDPqEQKFTGLPQQWHSLLAdtaNRPKPMVD 55   human
AAO53078   354 FSVGSPFNVKHNIHVNYHS-VTGFEGLPKEWEVILQs-sGITREDVV 398  Dictyostelium discoideum
AAF82310   111 STVSQPFNLKHEVHVDFNS-ATGFSGLPKEWEVILKs-sNVSKQEVL 155  Dictyostelium discoideum
AAO52430   364 LVIGSPTLIRRDIHITWNHvSGQFEGVPDEWQSMLQp--ITSEKQRK 408  Dictyostelium discoideum
AAO52430   104 PVISSPFGFAHITHVNFDSsNQELTGLPRDWGKTLKr--SVNKLVTV 148  Dictyostelium discoideum
CAC40979     9 VEISAPSNFEHRVHTGFDQqEQKFTGLPRQWQSLIEesaKRPKPLVD 55   African clawed frog

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