1B6A,1XGS


Conserved Protein Domain Family
MetAP2

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cd01088: MetAP2 
Click on image for an interactive view with Cn3D
Methionine Aminopeptidase 2. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
Statistics
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PSSM-Id: 238521
Aligned: 25 rows
Threshold Bit Score: 365.034
Created: 10-Jan-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active site
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:human methionine aminopeptidase-2 complexed with fumagillin

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                           #           
1B6A        166 WNDFREAAEAHRQVRKYVMSWIkpg---mtMIEICEKLEDCSRklikenglnagLAFPTGCSLNncAAHYTpnagdttVL 242 human
Q58725        6 YEKIIEAGKIASKVREEAVKLIxpg---vkLLEVAEFVENRIRelg------gePAFPCNISINeiAAHYTpklndnlEF 76  Methanocaldococc...
O27355        5 IESYLKAGKIVSKVRREAAGIIrdg---lpIIELVNYVEDRIIeeg------grPAFPCNVSVNevTAHYTsppgddsVI 75  Methanothermobac...
NP_394893     6 AEIKRKYLEAGRIGKKALEIGAsmiepgarLLDVANAMEKFVKdeg------alPAFPVNLSINndAAHYTpaindkkTF 79  Thermoplasma aci...
ZP_00077980  12 LEKYREAGRILKTVRAEAVEMVrvg---ntLLQVAEFVENRTIelg------grPAFPCNISRNqeAAHATpki-gdtDV 81  Methanosarcina b...
P95963        6 LNKLLLAGKIAAKARDEVSLDVkas---akVLDICEEVESIIIenk------afPSFPCNISINseAAHYSptindekRI 76  Sulfolobus solfa...
ZP_00001046   6 KNKYILAGKIGRDALEYAQTLIepg---alFYDVAEKAEQFIRdkg------avPSFPVNLSINneAAHYTpyegdkkKF 76  Ferroplasma acid...
NP_559774     2 LRILRQVGDVVNKALKYALDLTqpd---mpVLELCERVEAFIRand------akPAFPVNVSVNevAAHYTakrgdslKI 72  Pyrobaculum aero...
NP_280587    12 YEQYVEAGDILTTVLSEAADRVtvg---atHLEVASFAEERIRelg------gePAFPVNISVNeeASHAApga-dddTE 81  Halobacterium sp...
NP_941797     3 IDKILEAGRIAKEAREYAQKLCksi---tdGLELAIKVEEFIKkr-------akLAFPVNVSIHnvAAHFSpi----ePI 68  Nanoarchaeum equ...
Feature 1               #          #                                                            
1B6A        243 QYDDICKIDFGTHIsGRIIDCAFTVTFnp--kYDTLLKAVKDATNTGIKCAGIDv----rLCDVGEAIQEVMESyeveid 316 human
Q58725       77 KDDDVVKLDLGAHVdGYIADTAITVDLsn--sYKDLVKASEDALYTVIKEINPPm----nIGEMGKIIQEVIESy----- 145 Methanocaldococc...
O27355       76 GDGDLVKLDLGAHVdGFIADTAITVPVg---dVDDKCHQMMDAAREALENAISTiragveVGEIGRVIEETIHSh----- 147 Methanothermobac...
NP_394893    80 KTGDVVKVDFGAHIdGYMSDTAITVEVgeqgkHSDLIDAARQALNAAIELVRPMk----sVNEIGRRIAEVISSy----- 150 Thermoplasma aci...
ZP_00077980  82 FGKDMVKLDLGVHVdGYVADSAVTVDLs---gNSDIKKAAEEALAAAIDLAKPGi----sTGELGAAIENSIRSy----- 149 Methanosarcina b...
P95963       77 PEGAVVKLDLGAHIdGFISDTAITISLds--rYQRLLDASKTALEAAITNFKAGl----sIGEIGRVIEKVIRAq----- 145 Sulfolobus solfa...
ZP_00001046  77 KTGDLVKVDLGAMVdGYMSDNAATIEVgntgnYSDLIDATRDALNSAIKILRPLi----nIYRIGEEIGNVITSr----- 147 Ferroplasma acid...
NP_559774    73 PKTGLVKIDVGAQRdGYIVDAAVTVTLgp--vFNNLQKAAKSALESAINAAKPGi----kAWQIGEVVERVIKSf----- 141 Pyrobaculum aero...
NP_280587    82 FGEDMVCLDVGVHVdGHIADAATTVDLs---gTPELVEAAEESLAAAIDMVEPGv----qTGALGAEIQDVVEAy----- 149 Halobacterium sp...
NP_941797    69 EMYGVVKIDLGANVdGYLSDTAFSCDLdg--nYEELVEASKKALENASKIMRYGv----tLSEIGKTIEETIKSy----- 137 Nanoarchaeum equ...
Feature 1                     #                                 #                               
1B6A        317 gktyqVKPIRNLNGHSIGQYRIHAGKTVPIVKgge-atRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKnfdvghvpir 395 human
Q58725      146 ----gYKPISNLSGHVMHRYELHTGISIPNVYert-nqYIDVGDLVAIEPFATDGFGMVKDGNLGNIYKFlakr---pir 217 Methanocaldococc...
O27355      148 ----gMNPVSNLTGHSMERWILHSGLSIPNINern-thQLEEGDVLAIEPFATDGVGLVTDMPQTYIFRFlrer---plr 219 Methanothermobac...
NP_394893   151 ----gFKPVRNLGGHGVERYDLHASIFIPNYDdgn-vvRLQPDHAIAIEPFASTGIGMIHEGQPGNIYMId--------- 216 Thermoplasma aci...
ZP_00077980 150 ----gLNPILNLTGHGLSQYEAHDDPSVPNRHveg-gaILKEGDVLAIEPFATDGVGAVHDGNWAEIYSLirkk----pv 220 Methanosarcina b...
P95963      146 ----gYKPIRNLGGHLIRRYELHAGVFIPNVYerg-lgVIQSDSVYAIEPFATDGGGEVVEGKSITIYSLknpni--kgl 218 Sulfolobus solfa...
ZP_00001046 148 ----gFNPIKNLGGHGINRYDLHSEIFIPNYDdgn-deTIKTDKVIAIEPFASTGIGMIHSGQMGNIYIId--------- 213 Ferroplasma acid...
NP_559774   142 ----gLSPIYNLTGHKVERYLLHAGHVIPNYSdktasqALAPGDVYAIEPFATNGEGYVVDGGEITIYRLarm------r 211 Pyrobaculum aero...
NP_280587   150 ----gYNPVVNLTGHGMDVFDAHTGPTVPNRGvds-gaELAVGDVVAIEPFVTTGTGKVTEGAATEIYEVvssg---tvr 221 Halobacterium sp...
NP_941797   138 ----gFNPIKNLTGHSIEYNQLHGGLYIPNYDng--dkTIIKEGLYAIEPFATMGKGYVRNGPPSNIYILvkpk---rvr 208 Nanoarchaeum equ...
Feature 1                                                                        #              
1B6A        396 lPRTKHLLNVINENFGTLAFCRRWLDrlg--eskYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVS 473 human
Q58725      218 lPQARKLLDVISKNYPYLPFAERWVLkn----esERLALNSLIRASCIYGYPILKERENGIVGQAEHTILITENGVEITT 293 Methanocaldococc...
O27355      220 lVHARRVLGKIREEYHALPFAQRWLEeyfd-akrLNASMRMLIQSRAIYPYHVLREKSGAMVAQWEHTVIVEEDGCTVIT 298 Methanothermobac...
NP_394893   217 -RPKPREDEIIYRNFNKLPFAERWLEglv---edPKSYIKRMMASKELYSFPVLKEHNGAFIAQFEHTMIVLNDEVIVTT 292 Thermoplasma aci...
ZP_00077980 221 rLPAVRNVLKQVEEYRELPFAKRWLKsd-----kLDFVLIQLEKAGIIHSYPVLLESAGGLVAQAEHTIIVTQDGCEITT 295 Methanosarcina b...
P95963      219 sSRENELIDFIYTRFNYLPFSERWLKefstnvdeLRNNIKNLVKKGALRGYPILIEIKKGVVSQFEHTVIVKGDSIIVST 298 Sulfolobus solfa...
ZP_00001046 214 kPGVRDRDEILYKNFNTAPFAERWVSrlm---knDQEYIRKKMSTKYVSGFPVLKEHSKSMIAQSEHTIMVLGDEIIVTT 290 Ferroplasma acid...
NP_559774   212 hKNYQHLIDIISAEAGPLPFTPRWFPq------lTDDAIREALKAGVLQGYEVLVERSKGFVAQFEDTVYVGENEVIPLV 285 Pyrobaculum aero...
NP_280587   222 dRRARQLLDDLEQFDGLPFAARWLDGa------rAEMSLTRLERADIVRSYPVLKEADGELVGQDEHTLIVTEDGCEVVT 295 Halobacterium sp...
NP_941797   209 dIRARKVLQYIIENYGWLPFAKRWLIee-----fGPIDRELYYLLKEGIIYSYPQLIEEKPVSQFEHTFLVLKDKTIITT 283 Nanoarchaeum equ...
Feature 1        
1B6A        474 R 474 human
Q58725      294 K 294 Methanocaldococcus jannaschii
O27355      299 E 299 Methanothermobacter thermautotrophicus
NP_394893   293 R 293 Thermoplasma acidophilum
ZP_00077980 296 K 296 Methanosarcina barkeri
P95963      299 K 299 Sulfolobus solfataricus
ZP_00001046 291 K 291 Ferroplasma acidarmanus
NP_559774   286 R 286 Pyrobaculum aerophilum str. IM2
NP_280587   296 A 296 Halobacterium sp. NRC-1
NP_941797   284 L 284 Nanoarchaeum equitans Kin4-M

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