Conserved Protein Domain Family
APP
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cd01085: APP 
X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, even from a dipeptide or tripeptide.
Links
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Statistics
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PSSM-Id: 238518
Aligned: 38 rows
Threshold Bit Score: 288.306
Created: 10-Jan-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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active site
Feature 1:active site [active site]
Evidence:
  • Comment:Inferred from parent family alignment
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                           #          
NP_065116  329 GMRRAHIKDAVALCELFNWLEKEvpkgg---vteiSAADKAEEFRRQQadfvdlsfPTISSTGpngaIIHYApvpe-tnr 404  human
NP_477409  321 GFINSHIRDGVALCQYFAWLEDQvnkga--evdemSGADKLESFRSTKdkymglsfTTISASGpngsVIHYHpkke-tnr 397  fruit fly
XP_310616  384 GMRRAHVRDGAAVVRYLHWLEQSvdggn---vtelSGAAQLHDFRRQQdlfvdlsfAAISAFGpngaIVHYSpsed-tdr 459  Anopheles gambia...
O43895     364 LLKASHVRDAVAVIRYLVWLEKNvpkgt---vdefSGAEIVDKFRGEEqfssgpsfETISASGlnaaLAHYSptke-lnr 439  human
AAH54906   390 ILKEAHVRDAVAVMQLLLWLEKKvpega---eteiTAALYADQCRSKQknsrgpsfETISASGpnaaLAHYSpsnd-tar 465  zebrafish
NP_491489  325 GMRNSHLRDSAALVEFLCWLEKEllsgk--ryteiELADKIDHLRSLQdkyvtlsfDTISAVGdhaaLPHYKplgesgnr 402  Caenorhabditis e...
NP_702406  469 NMKQAHILDGLALLQFFHWCEQKrktkelfnetemSLRHKVDYFRSTKknfifpsfSTISASGpnaaVIHYEctd--ktn 546  Plasmodium falci...
XP_312988  332 GMRQAHIRDGVAMCEVLSRLEERfiagd--hitelSLAREIDHARKTQnnsegiafPTSVAYGvhssMPNYTpsn--rtn 407  Anopheles gambia...
NP_650221  371 GMRRAHIRDGAAICEAMSNMETRfhteq---wteeKIKYEVELWRLSQkhakglslRTVVAYGeh-sALPYYissnvtni 446  fruit fly
NP_504162  772 GMRASNLRDSIAIVEFLCKFEKErrdgy--tfteyELAADIEEVKTRNreyiglkqPTIFSAGeh-sSVHAHrpd--aqk 846  Caenorhabditis e...

Feature 1                #          #                                                          
NP_065116  405 TLSLDEVYLIDSGAQYkDGTTDVTRTMHFgtptayEKECFTYVLKGHIAVSAAVFPTgt-kgHLLDSFARSALWDSgldy 483  human
NP_477409  398 KINDKEIYLCDSGAQYlDGTTDVTRTLHFgeptefQKEAYTRVLKGQLSFGSTVFPAkv-kgQVLDTLARKALWDVgldy 476  fruit fly
XP_310616  460 PITRDGIYLIDSGGQYlDGTTDVTRSVHLgeptafQRECFTRVLKGFLSVAAAVFPVra-sgTTFDVLARKALWDVgldy 538  Anopheles gambia...
O43895     440 KLSSDEMYLLDSGGQYwDGTTDITRTVHWgtpsafQKEAYTRVLIGNIDLSRLIFPAat-sgRMVEAFARRALWDAglny 518  human
AAH54906   466 KLTVDEMYLVDSGGQYlDGTTDITRTVHWgkptdfQKEAYTRVLMGNIEISRTIFPAgt-rgVYMEMLGRRALWEVglny 544  zebrafish
NP_491489  403 KAAANQVFLLDSGAHYgDGTTDVTRTVWYtnppkeFILHNTLVLKGHINLARAKFPDgi-ygSRLDTLTRDALWKLgldf 481  Caenorhabditis e...
NP_702406  547 ATIKPAIYLLDSGGQYlHGTTDVTRTTHFgeptaeEKRIYTLVLKGHLRLRKVIFASyt-nsSALDFIARENLFNNfmdy 625  Plasmodium falci...
XP_312988  408 IELSEGMVLIDSGGQYeDGTTEVSRTLHLgeptaeQIRAYTNVLIGMIRLSMLTFPEnl-kpAELDALARGPVWGSmndy 486  Anopheles gambia...
NP_650221  447 EVSDQSLLVIESGGQYlEGTTDVSRTFIFgeptheMKKAYTNVLAGILHLAQLKFPSdl-kpSEVDALVRSMVWKDmtdf 525  fruit fly
NP_504162  847 IVFHYQQFMFQTGSHYtDGATNCARTIWDsypteeFMNQYTLVLKGHIRLASASFPKtltygSRLDIFARIALWDAgldy 926  Caenorhabditis e...

Feature 1               #                               #             #               
NP_065116  484 lhgtGHGVGSFLNVhegpcgis--yktfsdePLEAGMIVTDEPGYYEdgaFGIRIENVVLVVPVKTKYNFN 552  human
NP_477409  477 ghgtGHGVGHFLNVhegpmgvg-irlmpddpGLQANMFISNEPGFYQdgeFGIRVEDIVQIVPGQVAHNFS 546  fruit fly
XP_310616  539 ghgtGHGIGAFLGVheyppsfvsnsaspsnqGLVENMFSSNEPGYYEpgqFGVRIEDIVQVVNATAATVPH 609  Anopheles gambiae str. PEST
O43895     519 ghgtGHGIGNFLCVhewpvg-----fqsnniAMAKGMFTSIEPGYYKdgeFGIRLEDVALVVEAKTKYPGS 584  human
AAH54906   545 ghgtGHGVGNYFGVhewpvg-----fqsnniPFQEGMFTSIEPGYYKendFGIRIEDIAVTVPASTKHSSK 610  zebrafish
NP_491489  482 ehgtGHGVGHYLNVhegpigig-hrsvptggELHASQVLTIEPGFYAkekYGIRIENCYETVEAVVMSKAQ 551  Caenorhabditis elegans
NP_702406  626 nhgtGHGVGLTLNVheggcsi----gpvggaPLKKNMVLSNEPGYYMkdkFGVRIENMQYVISKEITDTTE 692  Plasmodium falciparum 3D7
XP_312988  487 phgtGHGIGSYSSVrespisis--ytakqrfTFKEGYFFSNEPGYYKngaFGIRLENVLEVVDTGKMHPTG 555  Anopheles gambiae str. PEST
NP_650221  526 pqatGHGIGSFGSVeeppisvs--ygknssfHFKQGYFFSSESGYYKrddFGVRLKNVLEVVDTGHTHPSG 594  fruit fly
NP_504162  927 dhetGHSVGHFLNIrdtqivig-repyssnsIIEAGQVMTIEPGYYSegmYGIRIGNCYETVDVTLSQNDQ 996  Caenorhabditis elegans

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