1IES,1LB3,1MFR,1R03,1Z6O,1Z6O,3ERZ


Conserved Protein Domain Family
Euk_Ferritin

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cd01056: Euk_Ferritin 
Click on image for an interactive view with Cn3D
eukaryotic ferritins
Eukaryotic Ferritin (Euk_Ferritin) domain. Ferritins are the primary iron storage proteins of most living organisms and members of a broad superfamily of ferritin-like diiron-carboxylate proteins. The iron-free (apoferritin) ferritin molecule is a protein shell composed of 24 protein chains arranged in 432 symmetry. Iron storage involves the uptake of iron (II) at the protein shell, its oxidation by molecular oxygen at the dinuclear ferroxidase centers, and the movement of iron (III) into the cavity for deposition as ferrihydrite; the protein shell can hold up to 4500 iron atoms. In vertebrates, two types of chains (subunits) have been characterized, H or M (fast) and L (slow), which differ in rates of iron uptake and mineralization. Fe(II) oxidation in the H/M subunits take place initially at the ferroxidase center, a carboxylate-bridged diiron center, located within the subunit four-helix bundle. In a complementary role, negatively charged residues on the protein shell inner surface of the L subunits promote ferrihydrite nucleation. Most plant ferritins combine both oxidase and nucleation functions in one chain: they have four interior glutamate residues as well as seven ferroxidase center residues.
Statistics
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PSSM-Id: 153114
View PSSM: cd01056
Aligned: 90 rows
Threshold Bit Score: 116.874
Threshold Setting Gi: 109493039
Created: 24-Sep-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:ferroxidase diiron center [ion binding site]
Evidence:
  • Comment:Iron(II) oxidation at the dinuclear centers of H/M subunits but not at L subunits.
  • Citation:PMID 9159481
  • Structure:1MFR; Homopolymer of frog M ferritin with two metal ions (Mg) in each ferroxidase center.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                      #      #                          ##  #                           
1IES_A         9 STEVEAAVNRLVNLYLRASYTYLSLGFYFDRDdvALEGVCHFFRELAEEKREGAERLLKMQNQRGGrALFQDLQKPs--- 85  Equus caballus
1MFR_D        10 HSDCEAAVNRMLNLELYASYTYSSMYAFFDRDdvALHNVAEFFKEHSHEEREHAEKFMKYQNKRGGrVVLQDIKKPe--- 86  bullfrog
AAK35224      51 TPETEHAVNKAIQLHQQAVLTYDHLAATCATEeiSMPGFCKFFRLCSQRHRELVEHWINFQTMRGGkLNVPEVKPLvqv- 129 Paragonimus wes...
BAC39994       8 SEECTKALNQVVAYHLHTSHVYFAMAHSFMTGkkETFPFVQHFETLADSRREYANRFLNHLWTRNKkICPPPTYEKvd-- 85  house mouse
XP_001057596  10 SEVILPLIHQVACIQMNLSDAYLYLTYLYSDDs-TATGFGAYVQDKSLTSWFYAQSVLKYITGRGNkVCIPDIQRPe--- 85  Norway rat
EDM11017       8 SQECTDALNRVVAYHLHTSHVYLAMAYSFRNDk-RIPPFVEYFETLANTRREDADAFLKHLWKRNTaICPPTLEKVd--- 83  Norway rat
ABR88146      48 GKTVENDLKQYTSQLVDKSFHFLMMSSAFNKHslDRPGFEKLYRKISDKAWADAIELIKYQSRRGSfGHLVQPSKGeny- 126 African malaria...
XP_001648938  41 YAYVTTDIADLTTQLLDQSYDFLFLSTAFNQHnkDRPGFEKLYRNIADKAWADAIALMKYQSKRGHrAKLNAGYKYanhe 120 yellow fever mo...
XP_001654517  36 INYVQDDLQAFTNQQLDKSFDFLVLSAKLGRA--TRPGFQKLYRKISDQAWKDTAKLIKYQSKRGLsVQINAPKDKvlnt 113 yellow fever mo...
XP_001849817  40 FSHVEKDMHKYTKQMLVKSYDFLLLSSVFDQYsmDRPGFEKLYRKIADKAWDDTIDLIKYQSRRGAvVTLDETNFAhnv- 118 southern house ...
Feature 1                                 #                                               #      
1IES_A        86 --------qDEWGTTLDAMKAAIVLEKSLNQALLDLHALGSaq--------------aDPHLCDFLEshFLDEEVKLIKK 143 Equus caballus
1MFR_D        87 --------rDEWGNTLEAMQAALQLEKTVNQALLDLHKLATdk--------------vDPHLCDFLEseYLEEQVKDIKR 144 bullfrog
AAK35224     130 -------ndLSKTDLEKIVVIALKTEKTVEQYLRELHKIARsk--------------eDVAMSEYIEkkLILPQLHVIKM 188 Paragonimus wes...
BAC39994      86 --------mKEITTPKSALLMAQNMEETLTKILLALKAAARresdllkf--ltsvlckQREFKEYLEsqLSPPQKGKRKN 155 house mouse
XP_001057596  86 ---------IDTQGRIQCAMAALNMEKELKVILHRLLDLALni--------------kDNQTLNHSKd-WIFKQQRNEER 141 Norway rat
EDM11017      84 --------mMEITTPIEAILLAQEMERTLTSILVGLQGAARr----------------ESDLLRLLTs-VLRKQRKNEDY 138 Norway rat
ABR88146     127 -------gkVLDVQELSSLQFALDYEKQMAKEAHAIHRKIShahskagsngsddvyhyDPDAAHYLDenIIEYQSGVVRD 199 African malaria...
XP_001648938 121 l---rsladPTLAEEHKSLKLAMEYEKLVAETTHAIHRKSSvahqs--------ppqyDPDVAHFFDekIVQGRADSVRK 189 yellow fever mo...
XP_001654517 114 mnngkyknqPVFDFREESLELAVDYDQFLAEESHRIHRKISqaqds-------egsryDPDVAHFLDeqFIQPQSDTIRK 186 yellow fever mo...
XP_001849817 119 -------ssLLTSNEASSLKLALDYEKLMATEAHMMHKKIShtge---------snhyDPDAAHYLDenLIEYQSGTIRK 182 southern house ...
Feature 1                                        
1IES_A       144 MGDHLTNIQRLvgsq------aglGEYLFERL 169 Equus caballus
1MFR_D       145 IGDFITNLKRLglpe------ngmGEYLFDKH 170 bullfrog
AAK35224     189 MVNHVNGLRVSg------------NEYLYDRT 208 Paragonimus westermani
BAC39994     156 EKEAQTEQPSTss---------gvKGYLSSKR 178 house mouse
XP_001057596 142 LAREIDELKKKeqaqn---ravedETYLQGSP 170 Norway rat
EDM11017     139 MKTQLTFHQRVekeremqvqtkkpSTLLNRKP 170 Norway rat
ABR88146     200 LAGYVHNLKHFtsakh---aandlGNHVFDEF 228 African malaria mosquito
XP_001648938 190 LTGYIHQLEDIlnvdk---ntrdmGLHLFDQY 218 yellow fever mosquito
XP_001654517 187 LAGYFYKLRRItddtl----ikrlVIHSFDDY 214 yellow fever mosquito
XP_001849817 183 LSGHIRNLNDIlgeag----tkdlGLQMFDDY 210 southern house mosquito

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