1VLG,3E6R,1KRQ,2JD6,1EUM,1Z4A


Conserved Protein Domain Family
Nonheme_Ferritin

?
cd01055: Nonheme_Ferritin 
Click on image for an interactive view with Cn3D
nonheme-containing ferritins
Nonheme Ferritin domain, found in archaea and bacteria, is a member of a broad superfamily of ferritin-like diiron-carboxylate proteins. The ferritin protein shell is composed of 24 protein subunits arranged in 432 symmetry. Each protein subunit, a four-helix bundle with a fifth short terminal helix, contains a dinuclear ferroxidase center (H type). Unique to this group of proteins is a third metal site in the ferroxidase center. Iron storage involves the uptake of iron (II) at the protein shell, its oxidation by molecular oxygen at the ferroxidase centers, and the movement of iron (III) into the cavity for deposition as ferrihydrite.
Statistics
?
PSSM-Id: 153113
View PSSM: cd01055
Aligned: 144 rows
Threshold Bit Score: 121.055
Threshold Setting Gi: 26553747
Created: 24-Sep-2002
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
 
ferroxidase
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:ferroxidase diiron center [ion binding site]
Evidence:
  • Comment:Iron(II) oxidation by molecular oxygen to iron(III).
  • Structure:1VLG_A; Thermatoga maritima ferritin binds iron.
    View structure with Cn3D

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                      #                                ##  #                            
1VLG_A        17 SEKVRKALNDQLNREIYSSYLYLSMATYFDAe-GFKGFAHWMKKQAQEELTHAMKFYEYIYERGGRVELEAIEKPps--- 92  Thermotoga mari...
CAE20670       1 MNDLTKAINLHLACEFQASHTYLAMSIWLREk-DLAGFSSYMQIKSQEERGHADRLIAYLVDCDEQVELPAVEAPqr--- 76  Prochlorococcus...
YP_730744     19 NPDLLSAIQQHISIERYASVTYLAMSIWCAEr-ELAGFYQFFDGEAKDEQSHAVHFTQYLIARSQSNDLQTLDAPrq--- 94  Synechococcus s...
YP_730289     28 TQEMVEQLQAHLNLERQSSAAYFAAAIWFAEr-ELTGFAEYLRNEGKQEQEHAAKFADYLISRGQTVELDTIEAPrq--- 103 Synechococcus s...
ZP_01471843    2 SQELVGAIQQHINLELEASMTYLSMSIWCAEr-ELAGFYKFFSAESAEERGHAIQFADYLVARAQRNDLQPLQAPcq--- 77  Synechococcus s...
ZP_01085349   28 EAELHQGLCNHLQMELMASYTYFSLAVWFTQr-ELNGFAAFARAESDGERAHAGLFVDYLVARSQPVELSALSQPrq--- 103 Synechococcus s...
NP_456497      3 AVGMVQKLNTPMNLEFYASNLYLHLSEWCSEh-SLTGTATFLRTQAQGNVTQMMRMFNFMKNAGATPIVKAIDVPge--- 78  Salmonella ente...
NP_757681      9 DERIMDLVSKHYNVELCAANLYFHLATVSKAlgYDNVAAFFVKMGSDKQSAHMSRLVKYMMKVDSILKINQISVPel--v 86  Mycoplasma pene...
CAK98701       3 TKDIEKDLQHYIDEHIKMQFFCYNLSSAADKl-GFPGFSHYFQVQAQDEVLHQRRIMNFVLDRDGHYQIKNIAEEyk--- 78  Spiroplasma citri
YP_001437424   3 PLGVVQKLNAQMNQEFYASNLCLYYSDWCAQq-SLNGSATVLRQQAQHNVTQMMRLFDYLKQTGANPVVGALKSVkpdcs 81  Enterobacter sa...
Feature 1                       #                               #  ##                            
1VLG_A        93 nWNGIKDAFEAALKHEEFVTQSIYNILELASeekDHATVSFLKWFVDEQVEEEDQVREILDLLEKANGqmsVIFQLDRYL 172 Thermotoga mari...
CAE20670      77 nWGSTQDLFDQVYELEKDVTASINRIYSIAEqagERSATAMLDWFIAEQLQEEAEARFVRKRLRLAGDntaALLLLDQQF 156 Prochlorococcus...
YP_730744     95 nWDSLASLMATAFQMEADTTSSIQSVYALAErnsDTRTTVFLDPLIEAQIQSEDQFAYLLGRVKFANGdptALLVIDNEL 174 Synechococcus s...
YP_730289    104 tWPDPEEVIANVFRMEADVTTSVLLLYSIAErasDQRTTVFLDPVVDDQRISEHEAAYLLGRVKYANNeraAMMIIDAEL 183 Synechococcus s...
ZP_01471843   78 nWSKLEDVVFSSFRMEADTTSSIQHLYSIAErenDVRTTVFLDPLLEQQIGSEDQYAYLHGRIKFADNdstALLVIDGEV 157 Synechococcus s...
ZP_01085349  104 tWTNVEDVLVSVFEMEAEVTTSLQQLYSLAErcgDYRSSIFLDPLIKSQVDAESEVAHLLAQVRHCGTdfgALLILDQSL 183 Synechococcus s...
NP_456497     79 eLCSLEELFQKTLEDYQQRASTLSRLADEAKalnDASTLDFLHTLEKEQQQDGVLLQTILEEVRSAKRa--GLCLAQTDQ 156 Salmonella ente...
NP_757681     87 sFETIQEVLDAALKMESKVRESVKNVTEISLlakDFETFERMQWFVKDSIEDLEEISDVWTYVHSPNV---NLINIENIV 163 Mycoplasma pene...
CAK98701      79 dIKNIIELMETYQTKRAYFAELTNKLAQHANtvgDLVTYKFYDWFIIDFYEELAEVKDIIEWIKMSNN---NYYEIDRKM 155 Spiroplasma citri
YP_001437424  82 sLEAIFHQMQDELGGRHAALARLMSEAQAAR---DDAMLAMLGEFEQELRQDEALLATILNELTQARQaglCAEEADQRL 158 Enterobacter sa...

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap