ferritin-like diiron-binding domain found in the reverse rubrerythrin/MJ0746-like family proteins
Reverse rubrerythrin/MJ0746-like proteins (revRbr/MJ0746) are members of the ferritin-like diiron-carboxylate protein superfamily and represent a distinct group of rubrerythrin-related proteins with a domain organization reversed relative to classical rubrerythrins. They contain an N-terminal rubredoxin-like domain harboring a mononuclear Fe(Cys)4 center and a C-terminal ferritin-like domain containing a dinuclear non-heme iron center. The family includes the archaeal protein MJ0746 and bacterial reverse rubrerythrins (Rubperoxins/NADH peroxidases). Structural and biochemical studies suggest that these proteins participate in peroxide detoxification and cellular defense against oxidative stress by coupling electron transfer through the rubredoxin-like domain to peroxide reduction at the diiron center.
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