Conserved Protein Domain Family
DMQH

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cd01042: DMQH 
Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain
Demethoxyubiquinone hydroxylases (DMQH) are members of the ferritin-like, diiron-carboxylate family which are present in eukaryotes (the CLK-1/CAT5 family) and prokaryotes (the Coq7 family). DMQH participates in one of the last steps of ubiquinone biosysnthesis and is responsible for DMQ hydroxylation, resulting in the formation of hydroxyubiquinone, a precursor of ubiquinone. CLK-1 is a mitochondrial inner membrane protein and Coq7 is a proposed interfacial integral membrane protein. Mutations in the Caenorhabditis elegans gene clk-1 affect biological timing and extend longevity. The conserved residues of a diiron center are present in this domain.
Statistics
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PSSM-Id: 153101
View PSSM: cd01042
Aligned: 65 rows
Threshold Bit Score: 149.6
Threshold Setting Gi: 215408407
Created: 24-Sep-2002
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
diiron binding
Feature 1:diiron binding motif [ion binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                   #                             #  #                                   
NP_057222     49 VDRIIRVDHAGEYGANRIYAGQMAVLGrTSVGPVIQKMWDQEKDHLKKFNELMVTFrvRPTVLMPLWNVLGFALGAGTAL 128 human
YP_001279826  51 VAGLMRINHTGEVCAQGLYHGQAFTAKdDLVKQAMQHSADEEIDHLVWCETRLDELgsHPSVFTPVWYGLSFGLGAIAGI 130 Psychrobacter s...
ZP_04988420   49 SAGLMRVDYTGEICAQGLYRGQASVAKsPQTKEHLYHAAAEEYDHLAWCSERLQELgaRPSLLNPFWYWASFGIGAVAGS 128 Francisella tul...
YP_002514853  50 AGRLMRVNHAGEVSAQGLYQGQALTARnAVVRENMERSAEEENDHLRWCQARMDALgaHRSYLNPLWYAGSFTLGAIAGL 129 Thioalkalivibri...
ZP_01451383   72 AAGLMRVNHAGEMAAQALYQGQSLTARdPALAERLKHASVEESDHLNWCRRRLTELdeKPSLLDPLWYAGSFAIGMAAGI 151 Mariprofundus f...
ZP_05062608   53 AAGLMRVNHSGEIAAQALYKGQSLLARnKALWEHLQEAADEEVDHLAWCEDRLRELgsQPSRLAPFWYAGSYTMGALAGL 132 gamma proteobac...
NP_841703     46 SAALMRINHVGEVCAQALYQGQALTARnDRVRQALDQAAREETEHLAWTERRIAELggRKSFLNPLWYGGSFTLGLVAGV 125 Nitrosomonas eu...
ZP_03689478   49 STRLMRVNHAGEVAAQGLYQGQMLTARnPKIRAHLDQASREEGDHLHWCAQRVHELggHTSLLGPFWYIGSFSLGAAAGL 128 Thioalkalivibri...
ZP_05339411   46 AAALMRINHTGEICAQALYQGQALTARdAAVQEKLNHAAWEETEHLAWTSHRVHELggRLSLLNPFWYTGSLALGALAGA 125 Sideroxydans li...
NP_820847     53 SIGFMRVNHSGEVCAQALYHGQMATAKnPAVRALFTTAAKEETDHLAWCQERLEELggHTSYLNAFWYTNSFLIGLLAGL 132 Coxiella burnet...
Feature 1                     #                                   #  #                           
NP_057222    129 LGKEGAMACTVAVEESIAHHYNNQIRTLmeedpekyeELLQLIKKFRDEELEHHDIGLDHDAelapAYAVLKSIIQAGCR 208 human
YP_001279826 131 ISDEFSLGFVAETEAQVSEHLQDHIDQLpeq----dtRSKEILAQMNIEELEHREAALNHGGk--aLSAPVRISMRWMAN 204 Psychrobacter s...
ZP_04988420  129 ISDGLSYGFVVETEKQVMKHLDSHLKSLpvn----dnRSREILKQMYIDESEHAVEAEKAGGk--kLPKTVKAIMKLQSK 202 Francisella tul...
YP_002514853 130 AGDRWSLGFVGETERQVEHHLDEHLDTLpea----daRSRAVLAQMREDEIHHGAKAMDLGGae-lPWVVRKVVMPAVSK 204 Thioalkalivibri...
ZP_01451383  152 AGDRWNLGFLAETEHQVVRHLDSHLEHLppe----dsRSRAIIEQMKIDEQGHAELAENLGAa--eLPQAIKQVMKLTSK 225 Mariprofundus f...
ZP_05062608  133 AGDKWSLGFIEETEKQVTAHLESHLERLpek----dlRSRQIIEQMREDEMEHAESAHKAGAa--pLPEPIKRAMTGIAK 206 gamma proteobac...
NP_841703    126 LGDKWNLGFLAETERQVEAHLADHLQRLphq----dvRSRAIVTQMKVDEACHATMAVSHGGg--qLPAPVKVAMKFSSR 199 Nitrosomonas eu...
ZP_03689478  129 TGDAYSLGFIDETERQVERHLDRHLERLpks----deTSARILQQMKQDEVEHGAHAMALGGkp-pPWPVRNVLMPLTSS 203 Thioalkalivibri...
ZP_05339411  126 LGDKWNLGFLAETERQVGAHLQSHLDSLpaq----daKSRAVAQQMYVDEVGHADMAVELGAe--eLPLPVKLAMRGMSK 199 Sideroxydans li...
NP_820847    133 SGDPLSLGFVEETEKQVEIHLADHLRKIpsn----dlKSRKIVEYMQQDEIQHGLNARSSGAk--eLPYLVKKLMAFQAK 206 Coxiella burnet...
Feature 1                
NP_057222    209 VAIYLSER 216 human
YP_001279826 205 RMKNLAYH 212 Psychrobacter sp. PRwf-1
ZP_04988420  203 VMTTLAYR 210 Francisella tularensis subsp. novicida GA99-3549
YP_002514853 205 VMTRTAYW 212 Thioalkalivibrio sp. HL-EbGR7
ZP_01451383  226 VMTSLAAK 233 Mariprofundus ferrooxydans PV-1
ZP_05062608  207 VMTTTSFR 214 gamma proteobacterium HTCC5015
NP_841703    200 IMTRTAYW 207 Nitrosomonas europaea ATCC 19718
ZP_03689478  204 VMTRTAYW 211 Thioalkalivibrio sp. K90mix
ZP_05339411  200 VMTKTVYW 207 Sideroxydans lithotrophicus ES-1
NP_820847    207 VMTTLAYW 214 Coxiella burnetii RSA 493

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