1LKO,1B71,1YUZ


Conserved Protein Domain Family
Rubrerythrin

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cd01041: Rubrerythrin 
Click on image for an interactive view with Cn3D
Rubrerythrin, ferritin-like diiron-binding domain
Rubrerythrin domain is a nonheme iron binding domain found in many air-sensitive bacteria and archaea and member of a broad superfamily of ferritin-like diiron-carboxylate proteins. The homodimeric rubrerythrin protein contains a binuclear metal center located within a four helix bundle. Many, but not all, rubrerythrin proteins have a second domain with a rubredoxin-like hexacoordinated iron center. Rubrerythrin is thought to reduce hydrogen peroxide as part of an oxidative stress protection system but its function is still poorly understood.
Statistics
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PSSM-Id: 153100
View PSSM: cd01041
Aligned: 107 rows
Threshold Bit Score: 89.9486
Threshold Setting Gi: 225873137
Created: 24-Sep-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
binuclear metal
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:binuclear metal center [ion binding site]
Evidence:
  • Comment:The diiron site resembles those found in O2-activating diiron enzymes
  • Structure:1LKO_A; Desulfovibrio vulgaris Rubrerythrin binds two iron atoms [diferric (oxidized) Rubrerythrin]
    View structure with Cn3D
  • Citation:PMID 8646540
  • Structure:1B71_A; Desulfovibrio vulgaris Rubrerythrin binds one iron and one zinc atom
    View structure with Cn3D
  • Comment:Rubrerythrin appears to be able to change the ligand arrangements of one of its binding sites to bind different metals under different conditions.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                    #  #   #                         #  #                               
1LKO_A         8 RTEKNILTAFAGESQARNRYNYFGGQAKKDGFVQISDIFAETADQEREHAKRLFKfleggdleivaafpagiiadthANL 87  Desulfovibrio v...
NP_343973      8 KTAENLRHAFCGEAMANRRYLYFAKRADEEGYPEIAGLLRSIAEGETAHAFGHLDfirqggigdp--atdkpigtleQML 85  Sulfolobus solf...
EAY57658       8 KTEKNLKEAFAGESQANRRYLYFARKADVEGYPDIAGVFRDTAEGETGHAFGHFDflkevgdpa----tgepvgdtsTNL 83  Leptospirillum ...
YP_001021289  36 KTEQNLKDAFAGESQANRRYLYFANKADIEGQNDVAALFRSTAEGETGHAHGHLEfleavgdpa----tglpigssrQNL 111 Methylibium pet...
YP_001414893   8 KTWENLKEAFAGESQANRRYLYFAQKADVEGFNDVAAVFRSTAEGETGHAHGHLEfleevgdpa----tgepigatdKNL 83  Parvibaculum la...
ZP_05338566    7 KTEKHLKDAFAGESQANRRYLYFANKADIEGYADVAALFRSTAEGETGHAHGHLEyleqcgdpa----tglpfgstkDNL 82  Sideroxydans li...
YP_482197      8 KTHENLKEAFAGESQANRRYLYFARRADIEGLTDASSLFRDTAEGETGHAFGHLDflaevgdpa----tgeplgtttKNL 83  Frankia sp. CcI3
YP_001539903  10 KTYENLKAAFQGESMANRRYLYYARLARQKGLNDIAEVFEKTANAETGHAFGHLMylgvdpva------eieintieDAL 83  Caldivirga maqu...
ZP_04578129    9 RTEQNLIDAFANEAQCSAIYDYAGRRASVEGHNDISAKLETSAKIRQNQARGNLQilqknplt------glsntvtrLNL 82  Oxalobacter for...
ZP_04575932    7 KTEKNIIEAFINETQSALIYDYAAYRADVEGHNEIITKLRSSAAIRRGHAMGNMQllqknplt------dlstnitrLNL 80  Oxalobacter for...
Feature 1             ##  #                              #  #            
1LKO_A        88 IASAAGEHHEYtEMYPSFARIAREEGyEEIARVFASIAVAEEFHEKRFLDFARNIK 143 Desulfovibrio vulgaris
NP_343973     86 ESAVAGETYEWtQMYPGYAKVAREEGfNEIAEWFETLARAEKSHAEKFTGVLNQLK 141 Sulfolobus solfataricus
EAY57658      84 KSAVAGETYEYtQMYPGFAKIAREEGfSEISEWFETLAKAEKSHAGRFTQALKNLQ 139 Leptospirillum sp. Group II UBA
YP_001021289 112 MAAVAGETHEYtDMYPGMAKQARDEGfDEVADWFETLAKAERSHANRYQKALDALV 167 Methylibium petroleiphilum PM1
YP_001414893  84 KAAIAGETHEYtDMYPGMARTARDEGfDEIADWFETLAKAEKSHAGRFQKALDSLG 139 Parvibaculum lavamentivorans DS-1
ZP_05338566   83 KSAVAGETHEYtDMYPGMAKDARAEGfDEVADWFETLAKAERSHANRYQKALGELG 138 Sideroxydans lithotrophicus ES-1
YP_482197     84 ASAVAGETYEFtAMYPGFAKTAREEGfEEIADWFSTLARAEKTHAGRFKKALDALS 139 Frankia sp. CcI3
YP_001539903  84 KASIYGETYEWtQMYPAFAKVAREEGfLEVAEWLEAVAKVERFHANRFNEALEKYY 139 Caldivirga maquilingensis IC-167
ZP_04578129   83 QSLISTATKNYhDKYSKMAEVARDEGfDGIADWFDTLAKAERMEARLYEDALKTLL 138 Oxalobacter formigenes OXCC13
ZP_04575932   81 QSAIATATRLYhDVYPKMAEIAREENlDDIANWFETLAKAERMEAKLYEEALKTLL 136 Oxalobacter formigenes HOxBLS

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