1VDD


Conserved Protein Domain Family
TOPRIM_recR

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cd01025: TOPRIM_recR 
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TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a single-stranded DNA molecule coated with RecA to allow invasion of a homologous molecule. The RecFOR system directs the loading of RecA onto gapped DNA coated with SSB protein. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). In RecR sequences this glutamate in the first turn of the TOPRIM domain is semiconserved, the DXD motif is not conserved.
Statistics
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PSSM-Id: 173775
View PSSM: cd01025
Aligned: 51 rows
Threshold Bit Score: 125.709
Threshold Setting Gi: 53987524
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative activeputativetetramer
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:putative active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             ##  #                                                           # # #     
1VDD_D       80 RTICVVEEPGDVIALERSgeYRGLYHVLHGVLspmngvgpdklhIKPLLPRVGQg--------mEVILATGTTVEGDATA 151 Deinococcus radi...
CAB73517     81 NILCIVESPKDILTLEESqsYNGLYFVLDELNee---------kLEKLKQIILKln------isELIFALTHSINSDATI 145 Campylobacter je...
NP_207717    84 SQLCMVLHPRDVFILEDLkdFLGRYYVLNSIEev---------dFNALEKRLIEen------ikEIIFAFPPTLANDSLM 148 Helicobacter pyl...
YP_393797    81 TLLCIVENAKDILLLEENrlFDGRYFVLDSLEn----------fNLSGLESLVKng------veEIVFALTPSIANDAVI 144 Thiomicrospira d...
CAE09825     81 GQLCIVTHPKDIFILEESkhFEGRYFVIDSLEdc---------dFTLLRSLIVSlk------itEVIFAFSPSLSNDSII 145 Wolinella succin...
ZP_00369760  80 NIICIVQDSKDVLVLEDSgsYDGLYFVLDDISee---------nIIKLRSMIEHnk------ttEIFFAFTQGLNSDAIV 144 Campylobacter la...
CAE81097     80 ESICVVEEPSDIMRIESSgaFRGRYHVLHGAIsplegigpkelkIKELIDRVEDglsgtgpaikEIILALDADLEGDTTI 159 Bdellovibrio bac...
CAF24448     80 QIICVTAFPRDVFSIEETheYRGLYHVLGGVLsplenrgpehlsISRLKHRIQDlq------ikEVVIALDSTLEGDATA 153 Parachlamydia sp...
AAP98241     82 QSLCIVASPKDVFFLERSkvFKGRYHVLGSLLspitgkhienerLSILKSRIETlc------pkEIILAIDATLEGDATA 155 Chlamydophila pn...
ZP_00308908  81 RVVCIVEDIRDVLAIENTnqYFGVYHVIGGVIspmerigpdqlnINSLIERVITdte-----ikEIILGLSPTMEGDTTA 155 Cytophaga hutchi...
Feature 1                                             
1VDD_D      152 LYLQRLLeplgAAISRIAYGVPVGGSLEYtDEVTLGRA 189 Deinococcus radiodurans
CAB73517    146 FFIEDKFkglnLTFSKIAQGIPSGVNLENvDLISLNKA 183 Campylobacter jejuni subsp. jejuni NCTC 11168
NP_207717   149 LYIEDKLqhfhLTFTKIAQGVPTGVNFENiDSVSLSRA 186 Helicobacter pylori 26695
YP_393797   145 LYIEDKLsdftINFSKIAQGVPTGVSLENiDLLSLSRA 182 Thiomicrospira denitrificans ATCC 33889
CAE09825    146 FYVEDKLqdlgVSFSKIAQGVPTGVSLENiDQLSLTRA 183 Wolinella succinogenes
ZP_00369760 145 FFVEEKLkdlnLSFSQIAQGIPSGVSLENvDFISLHKA 182 Campylobacter lari RM2100
CAE81097    160 LYLAKQLqgkgLKLSRIAHGVPIGSDIDFvDDRTMGRA 197 Bdellovibrio bacteriovorus HD100
CAF24448    154 LFLKQELaaddIQISRLAFGLPMGSSLDYvDGGTLARA 191 Parachlamydia sp. UWE25
AAP98241    156 LFLKQELqhfsVNISRLALGLPIGLSFDYvDSGTLARA 193 Chlamydophila pneumoniae TW-183
ZP_00308908 156 FFITKKLksypIKISTIARGIPFGGELEYmDEVTLGRS 193 Cytophaga hutchinsonii

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