1EXC,1K7K,2MJP


Conserved Protein Domain Family
Maf_Ham1
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cd00985: Maf_Ham1 
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Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard nucleotides, such as hypoxanthine/xanthine NTP, but not standard nucleotides.
Links
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Statistics
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PSSM-Id: 238485
Aligned: 180 rows
Threshold Bit Score: 57.1258
Created: 7-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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putative active
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:putative active site [active site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           #    #                            #                  #                #     
1EXC_A        5 LILASQSPRRKELLDLlq----lpYSIiv-----sEVEEKlnrnfspeenVQWLAKQKAKAVADLhphaIVIGADTMVCL 75  Bacillus subtilis
ZP_00114689   4 LVIASGNAGKIREFQGllqhlplnVQAqpq---gfDVEETgs-------tFAANARIKATAVAAMag-sWALADDSGLSV 72  Synechococcus sp...
1K7K_A       26 VVLATGNVGKVRELASllsdfgldIVAqtdl-gvdSAEETgl-------tFIENAILKARHAAKVta-lPAIADDSGLAV 96  Escherichia coli
NP_819098     4 IVLASQNSSKLAEMQEllrdleikFIPqtef-svpDIEETgs-------tFVENAIIKARHAAKQtg-lPALADDSGLTI 74  Coxiella burneti...
NP_682587     7 AVLASHNAGKVKEFQGwlqpwigeLVAlpa---aiEIAETad-------sFVANACLKAATAAKVmg-eWAIADDSGLAV 75  Thermosynechococ...
P74432        4 LIVATGNPGKLAEMQTyleplgcqLTLkpt---eiEVEETgs-------tFYENACLKASQVAKAvn-qWAIADDSGLAV 72  Synechocystis sp...
P44598        5 IVLATGNKGKVKEMADvlsdfgfeVIAqtdl-gieSPEETgl-------tFVENALLKARYASEKsg-lPAIADDSGLVV 75  Haemophilus infl...
ZP_00042934   4 LVLATGNRKKLIELKRalagqpveLLGldafpqapEVVEDge-------sFAENAFKKAEALMQHtg-lAALADDSGLVV 75  Magnetococcus sp...
Q9PD73        4 LVLASGNAGKLGELRAmlagvalqITAqsef-gvqDVPETgl-------tFIENALIKARHACLMtg-fPALADDSGLIV 74  Xylella fastidiosa
NP_866525     7 LVLGTGNAKKLVELRMmlpeetiaLTAlseienaiDVVEDge-------tFSANAAKKATEQAKHle-rWVLAEDSGLSV 78  Pirellula sp.

Feature 1                                                                                       
1EXC_A       76 d---GEClgkpqdqeea-------------asmlrrlsgrSHSVITAVSIQAen---hsETFYDKTEVAFwslseeeiwt 136 Bacillus subtilis
ZP_00114689  73 nalgGAPgvhsaryaptdper-----iekllgalsnaserHAQFCAALCVAApdg-svlIEVEGRCDGWItttprgdggf 146 Synechococcus sp...
1K7K_A       97 dvlgGAPgiysarysgedatdqknlqklletxkdvpddqrQARFHCVLVYLRhaedptpLVCHGSWPGVItrepagtggf 176 Escherichia coli
NP_819098    75 aalnSAPgvfssryagknatdaeriqkvlealeaaddsdrSASFHCVIALMEnendpapLICHGVWEGEIareprgkngf 154 Coxiella burneti...
NP_682587    76 halqGAPgiysarygatdaer-----ierllremadvsdrAAEFICVIALARpdg-tiaVTTEGRCAGEIltaprgqggf 149 Thermosynechococ...
P74432       73 daldGAPglysarygntdrer-----iakllqalegvsqrQAQFICVVSIAApdg-siqLSTKGICSGEIthsprgdqgf 146 Synechocystis sp...
P44598       76 salnGAPglysaryageegndaknrekllaelahiaqeqrQAKFVSCIVFLQhptdpspIIAEGECCGVIgfeekgengf 155 Haemophilus infl...
ZP_00042934  76 dalhGAPgvrsaryageqasdae--nvdkllhamaghsnrAAHFHCTLALVTpeg--grACFEGRVDGWIvqaavgeggf 151 Magnetococcus sp...
Q9PD73       75 dalgGAPglysaryagtptdaaannakllemlrdvpvgrrSARFYAVIVLLRhaedpqpLIADGCWEGEIvfepcgsggf 154 Xylella fastidiosa
NP_866525    79 dalkGAPgvysaryagthgddeannekllreltdvpmdrrGAQFNCHLCLSDpdg-nvrLAESGICRGRIatersggagf 157 Pirellula sp.

Feature 1                                                    
1EXC_A      137 yietkepmdkagaygiqgrgalfvkkidgdyysvmglPISKTMRA 181 Bacillus subtilis
ZP_00114689 147 gydpifevsct------gltfaqmpltekkshghrgkAFALLEPQ 185 Synechococcus sp. WH 8102
1K7K_A      177 gydpiffvpse------gktaaeltreeksaishrgqALKLLLDA 215 Escherichia coli
NP_819098   155 gydpifyvpsh------qrtaaeldpqeknaishrgqALEQLSTV 193 Coxiella burnetii RSA 493
NP_682587   150 gydpvfwvpsq------qrtfaemspvekqqvshrgqALQRLREY 188 Thermosynechococcus elongatus BP-1
P74432      147 gydpifwlpeh------kktfaemtkvekqkvshrgkAFNKLIHQ 185 Synechocystis sp. PCC 6803
P44598      156 gydslffspeq------gctfaeletaekkkishrakALSVLKSK 194 Haemophilus influenzae
ZP_00042934 152 gydplfqpege------artfaqmaphekdamshrgrAVNAFVAA 190 Magnetococcus sp. MC-1
Q9PD73      155 gynpiffdply------gmtaaqmgaelknkishrarALEQLRDC 193 Xylella fastidiosa
NP_866525   158 gydplfvipey------hktfgelnltvkralshrsrALRLFIPQ 196 Pirellula sp.

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