1G18,1XP8,2REC,3HR8,3CMT,1UBC,4PO1,2ZRC,2ZR0,4OQF,2ZRH,1U94,1N03,5JRJ,3CMT,3CMT,3CMT,3CMT


Conserved Protein Domain Family
RecA

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cd00983: RecA 
recombinase A
RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange.
Statistics
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PSSM-Id: 410863
Aligned: 63 rows
Threshold Bit Score: 307.56
Created: 12-Aug-2003
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
ATP bindinghexamer
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Structure:1G18; Mycobacterium tuberculosis RecA bound to ATP analog ADP-AlF(4),contacts at 4A
    View structure with Cn3D
  • Comment:contains Walker A and Walker B motifs

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                    ########                         #  #            
1G18_A     37 PISVIPTGSIALDVALGiGGLPRGRVIEIYGPESSGKTTVALHAVANAQAAggVAAFIDAEHALDPDYAKKLGvdTDSLL 116 Mycobacterium tube...
Q9PR61     35 KINAISTGSIHIDQITGiNGIPVGKITEIYGNESSGKTTIALQTIAECQKTggTVVLLDLEGSFDINYAKSLKvdLTKLI 114 Ureaplasma parvum ...
CBK88063   37 DVEPIPSGSLLLDQALGiGGYPKGRIIEIFGPESSGKTTLALHAIAQVQKKggRAAFIDAENAIDPVYARNLGvdIDELI 116 Eubacterium cylind...
P78014     36 EIKTVSTGSLHLDEALGtGGLPLGRIVELYGNESSGKTTVALHAVASFQKAgkVACYIDAEGALDLSYAKAIGidLGKLL 115 Mycoplasma pneumon...
Q8EVC7     33 DNQVIKSGSILLDNAIGvGGYPKGKIIEIYGNESSGKTTIALQCVKECIKEggSVAYIDAECSIDSKYLSHLGidPTKLL 112 Mycoplasma penetra...
Q59486     50 HVQALPSGILSLDCAIGiGGYPKGRLIELFGAESSGKTTVALQAVAETQKNggYVAYIDAENSLDIEYAENLGvkSDSLI 129 Lactococcus lactis...
Q6KHC9     31 NVEIFSTGSLAIDHALGiNGFPKGRIIEIYGPESSGKTTIALHAIAEIQKSggVAAFIDAEHSIDPNYAKNLGvnIDNLI 110 Mycoplasma mobile
P42446     51 NIETFSSGSLLLDNALGiGGYPKGRIIEIYGPESSGKTTLSLHAICEVQKLggIAAFIDAEHSLEPKYCQTLGidTNKLL 130 Mycoplasma mycoides
Q6F1R0     39 DHDVISSGSFLIDQAIGiGGYPKGRVVEIFGPESSGKTTLALHAIAEAQKQgeIAAFIDAEHSLDLNYAKKIGvdINSLL 118 Mesoplasma florum L1
P47581     37 EIETISTGSLNLDEALGsGGLPLGRIVELYGNESSGKTTIALNAVASFQKAgkTACYIDAEGALDLAYAKSIGidLNKLL 116 Mycoplasma genitalium
Feature 1                                                                                   # 
1G18_A    117 VSQPDTGEQALEIADMLIRSGALDIVVIDSVAALVPRAELEgemgdshvGLQARLMSQALRKMTGALNNSGTTAIFINQL 196 Mycobacterium tube...
Q9PR61    115 ITQPQTGEQAFDMIETLIKTNSIDLIVIDSVAAMLPESEYQanmnealmGAHARLMSKGLRKIQPLINKSKTAIIFINQL 194 Ureaplasma parvum ...
CBK88063  117 LSQPDSGEQGLNIMLMLIDSGAVDLVVVDSVAALVPQAELDgemgdlqvGSQARMMSKAMRKLAGLMNHNECTAIFINQL 196 Eubacterium cylind...
P78014    116 VAHPKHGENAFALMESLIKTNKVALIVVDSVAALIPKQELEgnmddqtiGLHARMMSKGLRRVQSLLPESDTCLLFINQL 195 Mycoplasma pneumon...
Q8EVC7    113 VATPEYGEQAFSIIDALIKTNMVDLIVVDSVAALVPKNDIEssmedqsmGTHARMMSKGLKILQTSLSKHKTTVIFINQV 192 Mycoplasma penetra...
Q59486    130 FAQPDTGEEAFYMINEFVRTGAFDLIVVDSVAALTPASEIDgvk---mpGQQAKMMSEQLSQLVGKVNQTKTVIIFINQI 206 Lactococcus lactis...
Q6KHC9    111 LSQPDSGEQALEIVDILAKSSSIDLIVVDSVAALVPEVELNgemkdqvmGAQARLMSKALRKITGSLNKSKTTVIFINQI 190 Mycoplasma mobile
P42446    131 VSQPDNGEQALDILEMLINSNSIDLIVVDSVAALVPKTELDgemsdqsiGLQARMMSKALRKLNWLIAKSNTTVIFINQL 210 Mycoplasma mycoides
Q6F1R0    119 VSQPSYGEEALDILETLVKSNSISLIVVDSVAALVPKTELEgemsdqsiGLQARMMSKALRKLNGVISKSKTTVIFINQL 198 Mesoplasma florum L1
P47581    117 IAHPRHGENAFALIESLIKTNKISLIVIDSVAALIPKQELEgtieeqtiGLHARMMSKGLRRIQSILPDSKTCVLFINQL 196 Mycoplasma genitalium
Feature 1                                                                          ##     
1G18_A    197 RdkigvmfgspetTTGGKALKFYASVRMDVRRVEtlkdg-tnavGNRTRVKVVKNKclapfkqaEFDILYGKGISR 271 Mycobacterium tubercul...
Q9PR61    195 RekintffgnpemTTGGKALKFYASLRIETKKADlikeg-inkiGIKTKVTTVKNKlapplqtcFIDIFFGSGFDY 269 Ureaplasma parvum sero...
CBK88063  197 RekvgvvygnpetTPGGRALKFYSSVRIDIRKADaikng-tdivGNKVKVKVVKNKvappfksaVLEIMYGEGISY 271 Eubacterium cylindroid...
P78014    196 RekpgvmfgngevTTGGRALKFYASMRMEAKRSEllkdrfgnyvGIKSKLTVSKNKvarpfgvaFLEIMFNRGIVY 271 Mycoplasma pneumoniae ...
Q8EVC7    193 RekigvmfgnneiTTGGRALKFFSTLRLDVRRSEliksg-tdviGIRSKITVTKNKvappfkncFVDIFFNKGFDP 267 Mycoplasma penetrans HF-2
Q59486    207 RstmsglflnketTPGGSALKFYSSVRIEVKSGEkikdg-idtiGKKTTLHTVKNKvsspykkpTVINIFGDGFSQ 281 Lactococcus lactis sub...
Q6KHC9    191 RekigtffgnpetTPGGRALKFYSSIRLDVRKVSsvstg-evisGNNIKIKVVKNKlsapfkeaFTEIVFSKGISK 265 Mycoplasma mobile
P42446    211 RekigvifgnpetTTGGKALKFFSSIRLEVRKAEnilnn-yeiiGNKIKIKVVKNKtaipfkttTISLLYNKGIDK 285 Mycoplasma mycoides
Q6F1R0    199 RekigimfgnpetTTGGRALKFFSTLRIEVRKGEslien-givvANKVKVKVVKNKvavpfkqtLITIGYDKGIER 273 Mesoplasma florum L1
P47581    197 RekpgvmfgnnevTTGGKALRFYSSLRMEAKRVEllkdkfnnyvGIKTKVMVSKNKiakpfgvaILEIMFNRGFVH 272 Mycoplasma genitalium

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