Conserved Protein Domain Family
FwdC/FmdC
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cd00980: FwdC/FmdC 
FwdC/FmdC. This domain of unknown function is found in the subunit C of formylmethanofuran dehydrogenase, an enzyme that catalyzes the first step in methane formation from CO2 in methanogenic archaea, hyperthermophiles and bacteria. There are two isoenzymes, a tungsten-containing isoenzyme (Fwd) and a molybdenum-containing isoenzyme (Fmd). The subunits C of both isoenzymes (FwdC/FmdC) are characterized by a repeated GXXGXXXG motif.
Links
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Statistics
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PSSM-Id: 238480
Aligned: 10 rows
Threshold Bit Score: 194.105
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative
Feature 1:putative subunit interface
Evidence:
  • Comment:Sharp inward bend along one face of the domain allows it to wedge itself into the helix core of the protein, based on the structure of A. brasilense glutamate synthase
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                ##          #  ##   #          ###    #
O27600       45 VVKLGDFFEVsgepads-----aadikiIIDGDVYNTKRIGQDMTAGEILVKGNVNMYVGAGMkGGKITVEGNAKSWAGQ 119 Methanothermobac...
AAB89324     44 LVELGELFEVtkdgd---------dkklLLDGDFSRVKWIGCRMTDGEIVVKGSVGANCGAYMaGGKIVIEGNADDWLGA 114 Archaeoglobus fu...
NP_614813    45 TVELGEYFDVegdagds-----pgdtriVIEGDVPWVKLIGYRMSAGEILVKGDVGRHAGAEMkGGKLIVEGDADDWLGR 119 Methanopyrus kan...
Q58571       45 RIKVADIFDVelndie-------gepriVIKNSSPKLKYIGSKMTKGEIVVEGDAGMYVGAEMkGGKIVVNGNAESWAGQ 117 Methanocaldococc...
O27002       44 KRPLGEFFEIaetph--------adqliRIDGDVSRVKYIGSGMKSGKIIINGDVGLQLGCEMkGGEIEVNGNVSSWIGM 115 Methanothermobac...
NP_634002    45 QCPLGDFFNVevegkds-----ventklVFEGDVSRVKRIGQNMSAGEIEINGNVDMHCGFAMkGGKVVINGNADSWLGC 119 Methanosarcina m...
Q48943       77 TYPLSEFFEVtgnggss-----aaetliRIKGDAMRIKRIGESMSAGKIEIEGSAGMHVGTGMkGGELVVYGDADSWAGM 151 Methanosarcina b...
AAK30006     45 RIAAADLFDIagdd-----------aesVRISGSPKLDFAGRGMTRGSLIIDGDAGAYVGMHMkGGRLCVSGSAGLYAAC 113 Methylococcus ca...
ZP_00034574  46 RCIVGDIFDVsrheaadvpeaphagatlVVENAEPWLDRIGARMTDGHLVVHGSTGDYSGFQMaGGRLHIEGDAGHFTAC 125 Burkholderia fun...
T45154       43 GLTLGDVFEIsldg----------sdslVIEGGSARLDRVGAALSQGSIRVEGDVGQRLGEGMaAGSLTVTGSAGPYAGT 112 Methylobacterium...

Feature 1         #               ##  #  #  #        #####  ## #        ###    ## #            #
O27600      120 DMRGGELEIFGDAGDYVGSSYRGDWRGMSGGVITVHGNAGNEIGEYMNGGKIIIkGDVNIMPGIHMNNGLIIIEGNAvaR 199 Methanothermobac...
AAB89324    115 EMKDGEIIVKGNAANLVGCAYYGDATGMSGGKILIEGNAGNYIGEKMAGGEIEIkGNAGDFIGTEMKGGTIIIHGSCg-F 193 Archaeoglobus fu...
NP_614813   120 EMKGGEITVHGNAGNYVGSTYRGEWRGMSGGRILVKGDAGDEIGEWMSDGKIIVeGDAGIMIGIHMQGGTIIVRGDVgvR 199 Methanopyrus kan...
Q58571      118 NMKGGELLIKGNAGDYVGSAYRGDWRGMSGGTIIVEGNAGNEIGEFMSKGLIHIkGNVGIMAGIHQNGGIIIIDGDVdvR 197 Methanocaldococc...
O27002      116 EMHGGTIKINGNAGDYVGCAYRGEWRGMKGGKIIIQGNAGNNIGGGMMAGEIYIgGDAGNFCGIRMNGGEITVRGDAgrA 195 Methanothermobac...
NP_634002   120 EMSGGEIILNGNAAYYVGAGYRGESCGMRGGKITVNGNAKDYLGEHMCGGEILVkGDVGLLPAISNNGGRIVIEGNAt-M 198 Methanosarcina m...
Q48943      152 EMTGGLLHIKGNAGDHVGCAYRGKWHGMKGGRIVIEGSARHQLGGGMDGGEILVeGDVKSFCGIRQNGGLIFVKGSAlrG 231 Methanosarcina b...
AAK30006    114 ELKGGIVEICGNAGDLLGSALPGNKKGMSEGVVIVRGDAGDRVGDHMRRGSILIeGNAGMYLGARMTAGTIAVRGRIgaC 193 Methylococcus ca...
ZP_00034574 126 EMRGGRLTVTGHSGDFAAGALAGDMEGMTGGTLTIHGNAGARLADRMRRGLVLVgGNAGDFAASRLVAGTVGIAGQLgaH 205 Burkholderia fun...
T45154      113 GATGGTITIEGDAGDHAGGAVYAAKAGLDGATLVIKGAAGDHLGDRMRRGMILA-GSAGAFAASRMIAGTIVVSGALgdH 191 Methylobacterium...

Feature 1         #  #                                                                    
O27600      200 VGGEMAGGTIVVKGmi----------eEFLPGFKYLgvekdiev--------------ngetfpgaYYKFEGDH 249 Methanothermobacter th...
AAB89324    194 VGGDMKAGEIKIGGe-----------fELMPTFVRQ------------------------------EDAWVGDV 226 Archaeoglobus fulgidus...
NP_614813   200 PGAQMEGGTVVVCGra----------eDILPSFRYEglkedpv-----------------eeatgtFHLFTGDY 246 Methanopyrus kandleri ...
Q58571      198 VGGEMKAGAIVVYGkv----------eEILPSFKFEgivenpvikls--------kkdagtpiagtFYKFSGDY 253 Methanocaldococcus jan...
O27002      196 PGAEMVSGIIKIHGri----------sSLLPGFKEIstfke---------------------dgslMILFKGDL 238 Methanothermobacter th...
NP_634002   199 PASEMKNGTVIIKGev----------fDLLPSYKEEgteev---------------------dgvtYRKFTGDV 241 Methanosarcina mazei Goe1
Q48943      232 VGAEMAGGTIVIGGki----------eRFSPGFEFVsmensits--------------geveligeFKKFTGDY 281 Methanosarcina barkeri
AAK30006    194 AGYAMKRGTLLVYGspvsnrrhlqrlwFTYPRFPAFapqr----------------------lsglEYLLLGDS 245 Methylococcus capsulatus
ZP_00034574 206 YAYGMRRGTLLLAQqp----------aHLPPTFTEGgrgfdvfwallvrslateiapfsqwraaslPTRHAGDL 269 Burkholderia fungorum
T45154      192 PGYGMRRGTLIAGSh-----------gTLLPTFVETgtpdlvfvrllaqsl-khlgaaqasllsgtLRRYSGDL 253 Methylobacterium extor...

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