1DFX,1DXG,1VZI


Conserved Protein Domain Family
DSRD
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cd00974: DSRD 
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Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small, single-domain homodimeric protein; each subunit contains an iron atom bound to four cysteinyl sulfur atoms, Fe(S-Cys)4, in a distorted tetrahedral coordination. Its metal center is similar to that found in rubredoxin type proteins. Desulforedoxin is regarded as a potential redox partner for rubredoxin. Desulfoferrodoxin forms a homodimeric protein, with each protomer comprised of two domains, the N-terminal DSRD domain and C-terminal superoxide reductase-like (SORL) domain. Each domain has a distinct iron center: the DSRD iron center I, Fe(S-Cys)4; and the SORL iron center II, Fe[His4Cys(Glu)].
Links
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Statistics
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PSSM-Id: 238478
Aligned: 13 rows
Threshold Bit Score: 45.7862
Created: 7-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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non-heme irondimer interface
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:non-heme iron binding site [ion binding site]
Evidence:
  • Comment:Each iron atom is coordinated to four cysteinyl residues in a distorted tetrahedral arrangement
  • Structure:1DXG; Desulforedoxin
  • Citation:PMID 7666420
  • Structure:1DFX; Desulfoferrodoxin (iron center I)
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             #  #               ##       
1DFX_A        3 HLEVYKCTHCGNIVEVLHGGGAELVCCGEPMKHM 36  Desulfovibrio desulfuricans
1DXG_A        3 EGDVYKCELCGQVVKVLEEGGGTLVCCGEDMVKQ 36  Desulfovibrio gigas
1VZI_A        4 RLQVYKCEVCGNIVEVLNGGIGELVCCNQDMKLM 37  Desulfovibrio baarsii
O29425        4 VMQVYKCMVCGNIVEVVHAGRGQLVCCGQPMKLM 37  Archaeoglobus fulgidus
AAM07086      6 KGEKYRCEICGNEVVVTEVGGGTLVCCGEDMTLI 39  Methanosarcina acetivorans C2A
NP_281234     3 QYETYKCQKCGNEVEVQNVGGGKLSCCGEEMKCI 36  Campylobacter jejuni subsp. jejuni NCTC 11168
AAO36919     20 LLQVYKCQVCGNIVEVVHKGGGQLVCCNQPMKLF 53  Clostridium tetani E88
AAB85260      4 TNQIFRCNVCGNIVEVLNPGAGQLVCCNQPMELL 37  Methanothermobacter thermautotrophicus str. Delta H
ZP_00576094   4 ITQVYKCNICGNIVTILHPGGGALVCCGKPMELL 37  Moorella thermoacetica ATCC 39073
CAG36397      4 MKQIYKCELCGNIVEILTPGAGALACCGENMVLL 37  Desulfotalea psychrophila LSv54
CAI83720      6 LGETYKCDICGNIVRVIKVGGGTLVCCGQDMKRI 39  Dehalococcoides sp. CBDB1
ZP_00551845   4 RNEVYKCATCGNVLAILTGGQGELICCDAPMELM 37  Desulfuromonas acetoxidans DSM 684
ZP_00868686   1 MLELYHCNICGQMVLIVNEGKGTLVCCNQPMIHI 34  Methanospirillum hungatei JF-1

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