Conserved Protein Domain Family
CHBPH_aldolase
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cd00952: CHBPH_aldolase 
Trans-o-hydroxybenzylidenepyruvate hydratase-aldolase (HBPHA) and trans-2'-carboxybenzalpyruvate hydratase-aldolase (CBPHA)
Trans-o-hydroxybenzylidenepyruvate hydratase-aldolase (HBPHA) and trans-2'-carboxybenzalpyruvate hydratase-aldolase (CBPHA). HBPHA catalyzes HBP to salicyaldehyde and pyruvate. This reaction is part of the degradative pathways for naphthalene and naphthalenesulfonates by bacteria. CBPHA is homologous to HBPHA and catalyzes the cleavage of CBP to 2-carboxylbenzaldehyde and pyruvate during the degradation of phenanthrene. They are member of the DHDPS family of Schiff-base-dependent class I aldolases.
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Statistics
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PSSM-Id: 188639
Aligned: 8 rows
Threshold Bit Score: 467.308
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative activecatalytic
Feature 1:putative active site [active site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                   #  ###                            
Q51947     15 DINGAWTIMPTPSTPDASDwrstNTVDLDETARIVEELIAaGVNGILSMGTFGECATLTWEEKRDYVSTVVETi---rGR 91  Pseudomonas putida
BAA23263   10 DITGLVGIVPTPSKPGSEApdavDTVDLDETARMVELIVAsGVDVLLTNGTFGEVATLTYEELLAFNDTVIRTv---aNR 86  Nocardioides sp.
AAD09869   13 DVNGAWVIMPTPAKPEASDwratDTVDLDETARIVEALIDsGVNGILSLGTFGECATLTWEEKQAFIGAVVETt---rGR 89  Burkholderia sp. R...
BAA76332   11 DIHGVWSILPTPSKPDASDwratNTVDLDETARAVEGLIAaGANGILSMGTLGECESLTWEEKKVFMQTIVETa---rGR 87  Alcaligenes faecalis
AAD45417   10 DVKGAWAIIPTPAKDDASDwratKTVDLDETARVVNGLIDaGINGILSMGTLGEAATMTHDEKLDFIKALVDAa---aGR 86  Sphingomonas sp.
BAA94711   12 DMKGLWAFVPACSTPDAADvnavNTIDTEALLSLVDRLVRdGADGIVTTGSAGESHTLTTEEYRTLVATVVETv---nGR 88  Nocardioides sp. KP7
AAR05109    9 DLRGVVAVTPTPALPGAGElagrDTVDLEETDRMIRRLIAdGVDGIITNGTLGEMATLTLTEWQAFTRRVSEVvsevaPD 88  Rhodococcus sp. P400
AAT51742   12 DITGVVGIIPTPSIPTADQpgtaFSVDLDEAATLADAMVRgGVDVLMTTGTFGECASLTWDELQSFVATVVDAv---aGR 88  Mycobacterium vanb...

Feature 1                                                                    #                
Q51947     92 VPYFCGTTALNTREVIRQTRELIDIGANGTMLGVPMWvkMDLPTAVQFYRDVAGAVPEAAIAIYANPeaFKFDFPRPFWA 171 Pseudomonas putida
BAA23263   87 IPVFCGASTLNTRDTIARSLALMGLGANGLFVGRPMWlpLDDEQLVSYYAAVCDAVPAAAVVVYDNTgvFKGKISSAAYA 166 Nocardioides sp.
AAD09869   90 VPFFCGTTALNTREVVRQTRAALDIGVDGTMLGVPMWsrMEVPAAVQFYRDVAEACPEAAIAVYANAdaFKFEFPRAFWA 169 Burkholderia sp. R...
BAA76332   88 VPVFVGTTTLNTRDTIEQTRYAHSIGADGTMLGIPMWcnPCVDMAVQYYKDVAEAVPEMNIAIYANTeaFKFDFPRAFWA 167 Alcaligenes faecalis
AAD45417   87 VPIFVGTTCLNTRDTIALTRQALDIGADGTMLGVPMWcaPSVDVAVQFYKDLAEAVPEMNIAIYANPeaFKFDFPRSFWA 166 Sphingomonas sp.
BAA94711   89 VPVFVGASTLNTRDSIERARLIADLGADGIMSGPPMYlpQTPENAVQYYKDLAEAVPELAIMIYQNPhaFRITLPPAAFR 168 Nocardioides sp. KP7
AAR05109   89 LPLFIGATTLNTRDTVDRIRFLEDLGIQGVFLGRPMWggLGADTMAAFYRDIADTFPDMAMVLYDNPeaFKGPIPSPVYA 168 Rhodococcus sp. P400
AAT51742   89 IPVFAGATTLNTRDTIARGRRLGELGADGLFVGRPMWlpLDDAGIVRFYRDVAEAVPNMALVVYDNPgaFKGKIGTPAYE 168 Mycobacterium vanb...

Feature 1                #                                             #                      
Q51947    172 EMskipQVVTAKYLg----IGMLDLDLKla-pnIRFLPHEDDYYAAARINPeritAFWSSgaMCGPATAIMLRDeverak 246 Pseudomonas putida
BAA23263  167 ALaeipQIVASKHLgvlsgSDAYASDLAavkgrFPLLPTADNWLPSLEAFPgevpAAWSGdvACGPEPVMALRRai---- 242 Nocardioides sp.
AAD09869  170 QVaqipQVVTAKYLg----IGMLDLDLTla-pgIRFLPHEDDYYAAARVAPervtAFWSSgaMCGPATAIRLRDevakak 244 Burkholderia sp. R...
BAA76332  168 RVseirQVVAAKYIg----IEFLLQDLHltkhrMKLLPLDYQYYAAARMDDfv-dAFWSSgtVCGPLVSTTLRDkviaar 242 Alcaligenes faecalis
AAD45417  167 QVaeipQVVTAKYIg----VAHLLPDLAairgrIKLLPIDFDYYGAARMDEsi-dAFWSSgaVCDPLVTTTLRDlvsqar 241 Sphingomonas sp.
BAA94711  169 ELaqvkNVVALKQTsm--dIFNVIGAIKavkdkMAVLVLDQLMYPAMMFGAa---GGWSIdvCMGPWPALSLRDac---- 239 Nocardioides sp. KP7
AAR05109  169 ELatlpQVIGAKYIa---lTPKFAVDIAavdgkMRLLPLESDWLATRTLYPdealGCWSSsaLCGPEPVLALRDal---- 241 Rhodococcus sp. P400
AAT51742  169 ALsqipQVVAAKHLgl-lsGSAFLSDLRavsgrVRLLPLETDWYYFARLFPeevtACWSGnvACGPAPVTHLRDli---- 243 Mycobacterium vanb...

Feature 1                                                                                     
Q51947    247 stGDWIKAKAISDDMRAADSTLfprgdfsEFSKYNIGLEKARMDAAGWlKAGPCRPPYn-lVPEDYLVGAQKSGKAWAAL 325 Pseudomonas putida
BAA23263  243 aeGLWDDARAVHEDIAWATEPLfpggdisKFMPYSIQIDRAEFEAAGYiVPGPSRHPYg-tAPAAYLEGGAEVGRRWAGI 321 Nocardioides sp.
AAD09869  245 qtGDWRLAKELSDAMRRADATLfprgdfaEFSKYNIAIEKERMNAAGWlRAGPCRPPYh-iAPEEYLDGARQSGRAWAEL 323 Burkholderia sp. R...
BAA76332  243 rtKDWTDAHAFQGRLVKTAAPFped-sfkTFSIYNVALEKGRIDAAGWmNAGPVRPPYndiCPASYLDSWKASGQRWAEL 321 Alcaligenes faecalis
AAD45417  242 atGDWSAARAFMGRLGPTAAPLfpngsfkEFSTYNIALEKARMNAGGWmNAGPVRPPYh-lCPEPYLEGARLSGRMWAEL 320 Sphingomonas sp.
BAA94711  240 qrGDWTEAAAIADQMQAPMRSLglt--meEFQAMQSAWWKIAVDVAGYgRAGAARPPFv-hIPEAVVDSARRYGQRWAGL 316 Nocardioides sp. KP7
AAR05109  242 asGNLEAARHLTHRIDWTYEPFlartnfpEFSKYNVTLEKLRFDEAGYiNAGPARPPFl-tAPEAYAEGARENGRRWRHL 320 Rhodococcus sp. P400
AAT51742  244 raRRWDDCQALTDELEGALETLypggnfaEFLKYSIQIDNAQFQAAGFmRTGPTRPPYt-eVPESYLAGGREAGKNWAAL 322 Mycobacterium vanb...

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