1B57,1DOS


Conserved Protein Domain Family
FBP_aldolase_IIA
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cd00946: FBP_aldolase_IIA 
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Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is homodimeric and used in gluconeogenesis and glycolysis. The type A and type B Class II FBPA's differ in the presence and absence of distinct indels in the sequence that result in differing loop lengths in the structures.
Links
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Statistics
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PSSM-Id: 238476
Aligned: 14 rows
Threshold Bit Score: 492.269
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:active site
Evidence:
  • Comment:substrate (phosphoglycolohydroxamate, PGH) binding causes a conformational change in the mobile loop of the enzyme.
  • Structure:1DOS_A; substrate free; open conformation
  • Comment:the mobile loop closes over the active site after substrate binding.
  • Structure:1B57_A; substrate bound ; closed conformation
  • Citation:PMID 9878448
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                            #                                                          
1B57_A       14 GDDVQKVFQVAKENNFALPAVNCVGTDSINAVLETAAKVKAPVIVQFSNGGASFIAGKGVKsdvpq-gaailGAISGAHH 92  Escherichia coli
AAM66752     56 GKALLDLLDSAKEQGYAIPGVNVVGSNSINACMEAAKKYGGPIMVTFSKGGGQFIAGKAADntddk--asiaGCVAAAKH 133 Odontella sinensis
AAO43262     71 GQAQMDLLNHAKEHGYAIPAVNCVSNSGINACLEAARKNDAPIIIQFSSGGSQFYGGKGLDnsnyr--aaiaGAVSGAFH 148 Phaeodactylum tr...
P36580       14 GDNVLKLFTYAREHGFAIPAINVTSSSTAIAALEAAREARSPIILQTSNGGAHFFAGKESSnegqk--asiaGSIAAAHY 91  fission yeast
P53444       16 GDDVLKLFQYAREKQFAIPACNVTSSSTAVAALEAARDQKAPIILQTSQGGAAFFAGKGIKdsaekreasvaGAIAAAHY 95  Neurospora crassa
P14540       16 GEDVHNLFTYAKEHKFAIPAINVTSSSTAVAALEAARDSKSPIILQTSNGGAAYFAGKGISnegqn--asikGAIAAAHY 93  baker's yeast
EAL22365     15 GDNVRKLFKYAKDNKFAIPAINVTSSSVVNAVLEAARDINSPIILQVSQGGAAFFAGKGLKngnqe--asiaGAVAAAHF 92  Cryptococcus neo...
1DOS_A       14 GDDVQKVFQVAKENNFALPAVNCVGTDSINAVLETAAKVKAPVIVQFSNGGASFIAGKGVKsdvpq-gaailGAISGAHH 92  Escherichia coli
ZP_00309381  16 GDQVQDLFAAAKKAKLAFPAVNVVSTGTVNAVLETAKLANSPVIVQFSNGGGQFYAGKSLPngkqe--asiaGAISGAHH 93  Cytophaga hutchi...
O51401       14 GKELHFLYEICKKEGFAIPSINCIGTNSINAVLEAAKEINSPIMIQFSNSGSAFISGKGLKmekpq-gvsivGAISGAMH 92  Lyme disease spi...

Feature 1                       ##                                 #                            
1B57_A       93 VHQMAEhygVPVILHTDHCAKKlLPWIDGLLDAGEKHFaatgkPLFSSHMIDLSEESLQENIEICSKYLERMSKIGMTLE 172 Escherichia coli
AAM66752    134 VREVAAlygVPVVLHTDHCQKAwLPWFDGLMEANEEYYaqngePLFSSHMLDLSEEPLEENIAICKKYMERMAKIDMLLE 213 Odontella sinensis
AAO43262    149 VRTMAEqygVPVILHTDHCAKKlLPWIDGLLSASERYYeqhgePLFSSHMIDLSEEPIEENIEICKEYLTRMDKIGILLE 228 Phaeodactylum tr...
P36580       92 IRSIAPffgVPVVMHSDHCAKKlLPWMDGMFEADEAYFkihgePLFSSHMLDLSEEPKKENIAQVKEYCKRAVPMKIWIE 171 fission yeast
P53444       96 IRSIAPiygIPVVLHTDHCAKKlLPWLDGMLEEDEKFFkangvPLFSSHMIDLSEEPVEENISTCVKYLKRMAPMKQWLE 175 Neurospora crassa
P14540       94 IRSIAPaygIPVVLHSDHCAKKlLPWFDGMLEADEAYFkehgePLFSSHMLDLSEETDEENISTCVKYFKRMAAMDQWLE 173 baker's yeast
EAL22365     93 IRSVAPhygVPVVLHSDHCAKKlLPWFDGMLEADEAYFkehgePLFSSHMLDLSEESKEDNIKDCVFYFKRMAKVNLWLE 172 Cryptococcus neo...
1DOS_A       93 VHQMAEhygVPVILHTDHCAKKlLPWIDGLLDAGEKHFaatgkPLFSSHMIDLSEESLQENIEICSKYLERMSKIGMTLE 172 Escherichia coli
ZP_00309381  94 VHQVSElygVGVILHTDHAAKKlLPWIDGLLDAGEAFYkvhgkPLYSSHMLDLSEEPLHENIEVCKRYLERMSKIGMTLE 173 Cytophaga hutchi...
O51401       93 VHLMAEhygVPVVLHTDHCAKNlLPWVEGLLEYGEKYYsqhkkPLFSSHMLDLSEEPIKENIEISKKFLERMAKIEMFLE 172 Lyme disease spi...

Feature 1        # #  ####                                           ### #                      
1B57_A      173 IELGCTGGEEDGvdnshmdasaLYTQPEDVDYAYTELski-sprFTIAASFGNVHGVYkpgnVVLTPTILRDSQEYVSKK 251 Escherichia coli
AAM66752    214 FELGITGGEEDGvdntdvdsarLYTQPEEVWYSYQQLseipnamFTCAASFGNVHGVYapgnVDLQPVILHNSQKYIQEK 293 Odontella sinensis
AAO43262    229 MELGITGGEEDGvdnsdrpiedLYSKPEEIYQVYEELmki-sdkFTVAAAFGNVHGVYspgnVKLEPKILSRAQDYISEK 307 Phaeodactylum tr...
P36580      172 MEIGITGGEEDGvdnshvshteLYTQPEDIWDVYRELssv-tpyFSIAAAFGNVHGVYkpgnVKLQPALLGQHQAYVKEQ 250 fission yeast
P53444      176 MEIGITGGEEDGvdnsevdnasLYTQPEDIWQIEEAFrpi-spyFSIAAGFGNVHGVYapgnVKLHPELLGKHQAYVSEK 254 Neurospora crassa
P14540      174 MEIGITGGEEDGvnnenadkedLYTKPEQVYNVYKALhpi-spnFSIAAAFGNCHGLYag-dIALRPEILAEHQKYTREQ 251 baker's yeast
EAL22365    173 MEIGITGGEEDGvdntsvdnnsLYTQPEDIWDVYSALnai-spnFSIAAGFGNVHGVYkpgnVKLRPELLGKHQKYTHEK 251 Cryptococcus neo...
1DOS_A      173 IELGCTGGEEDGvdnshmdasaLYTQPEDVDYAYTELski-sprFTIAASFGNVHGVYkagnVVLTPTILRDSQEYVSKK 251 Escherichia coli
ZP_00309381 174 IELGVTGGEEDGvdnsgihqdeLYTKPEEVAYAYEELmkv-sdkFTIAAAFGNVHGVYtsgsVKLEPKILRKSQDFIKAN 252 Cytophaga hutchi...
O51401      173 IELGITGGEEDGvdnsdralheLFSTPEDIYYGYSELlkv-spnFQIAAAFGNVHGVYkpgnVKLTPKVLKDGQDYVISK 251 Lyme disease spi...

Feature 1                       ## #                  # ##                                      
1B57_A      252 hnl----phnSLNFVFHGGSGSTAQEIKDSVSYGVVKMNIDTDTQWATWEGVLNYYKANeaylqgqlGNPKGEDQPNKKy 327 Escherichia coli
AAM66752    294 lete---dtkPMKFVFHGGSGSSVEDIRYAIEAGVIKMNIDTDTQWAYWDGIRAYEAKNhdylqgqiGNPEGEDKPNKKy 370 Odontella sinensis
AAO43262    308 lgdkapadkkPVAFVFHGGSGSDVADIQEAIGYGVIKMNIDTDTQWSYWEGIKNFETKYhdylqtqiGNPDGPDKPNKKy 387 Phaeodactylum tr...
P36580      251 lktt---ndkPVFFVFHGGSGSSVNEFRTGIKCGVVKVNIDTDTQFAYVEGVRDYVLKYkdylmtpvGNPEGADKPNKKk 327 fission yeast
P53444      255 lggk---dkkPVFFVFHGGSGSSKEEYREAISNGVVKVNVDTDLQWSYLVGIRDYILNNidylrsqvGNPEGPNKPNKKk 331 Neurospora crassa
P14540      252 vgck---eekPLFLVFHGGSGSTVQEFHTGIDNGVVKVNLDTDCQYAYLTGIRDYVLNKkdyimspvGNPEGPEKPNKKf 328 baker's yeast
EAL22365    252 iggd---eekPLYLVFHGGSGSSKEEIREAVVNGVVKMNVDTDTQWAYLCGVRDFVLKKkdylmtqvGNPEGADKPNKKq 328 Cryptococcus neo...
1DOS_A      252 hnl----phnSLNFVFHGGSGSTAQEIKDSVSYGVVKMNIDTDTQWATWEGVLNYYKANeaylqgqlGNPKGEDQPNKKy 327 Escherichia coli
ZP_00309381 253 ygrt---eenPLDFVFHGGSGSSQEEIREAIGYGVVKMNLDTDLQWAFWEGVLNYYKANeaylqgqiGNPKGADQPNKKf 329 Cytophaga hutchi...
O51401      252 tgvn---makPVSYVFHGGSGSTIDEINEALSYGVVKMNIDTDTQWAAWEGVLNYYKKNesrlqgqlGDGKDIDIPNKKf 328 Lyme disease spi...

Feature 1                                      
1B57_A      328 YDPRVWLRAGQTSMIARLEKAFQELNAIDVL 358 Escherichia coli
AAM66752    371 YDPRMALRSGEEAMADRLVKAAEDLNCVNVL 401 Odontella sinensis
AAO43262    388 YDPRESMRAAEVNTVARLGKSYADLKCQNIL 418 Phaeodactylum tricornutum
P36580      328 FDPRVWIHEGEKTMTKRVLTALEDFYTVNTL 358 fission yeast
P53444      332 YDPRVWIREGEKTMKARVEEALKDFNAAGTV 362 Neurospora crassa
P14540      329 FDPRVWVREGEKTMGAKITKSLETFRTTNTL 359 baker's yeast
EAL22365    329 YDPRVWVREGEKTLVERVKEACVDLGNNNRN 359 Cryptococcus neoformans var. neoformans B-3501A
1DOS_A      328 YDPRVWLRAGQTSMIARLEKAFQELNAIDVL 358 Escherichia coli
ZP_00309381 330 YDPRVWLRKGEDTFVARLKKAFEDLNSFDAN 360 Cytophaga hutchinsonii
O51401      329 YDPRVWLREAEVSMKDRVKIACKNLNNINRN 359 Lyme disease spirochete

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