Conserved Protein Domain Family
HisRS_RNA
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cd00938: HisRS_RNA 
HisRS_RNA binding domain. This short RNA-binding domain is found at the N-terminus of HisRS in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). This domain consists of a helix- turn- helix structure, which is similar to other RNA-binding proteins. It is involved in both protein-RNA interactions by binding tRNA and protein-protein interactions, which are important for the formation of aaRSs into multienzyme complexes.
Links
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Statistics
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PSSM-Id: 238474
Aligned: 7 rows
Threshold Bit Score: 72.117
Created: 24-Sep-2002
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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tRNA binding
Feature 1:tRNA binding site [nucleic acid binding site]
Evidence:
  • Comment:based on similarity to EPRS RNA-binding domain
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1               # #  #    #    #   #       #       #
P12081       5 AALEELVKLQGERVRGLKQQKASAELIEEEVAKLLKLKAQLGPDE 49   human
NP_728180    6 EQILEQIKVQGDLVRQLKAAKESKEKIDEEVARLLALKATLGGDA 50   fruit fly
XP_214237 1258 STQNIPILGQGSHVRGLKEEKASAEQIEEEVTKLLKLKAQLGHDE 1302 Norway rat
CAF92276     5 AKIQEAIKIQGEVVRKIKAEKASKEQIDKEVAKLLELKAHLGGDD 49   Tetraodon nigroviridis
AAH76748     8 AELEKALTLQGEKVRKLKQEKASSEAIAEEVAKLLELKAQLGTDD 52   African clawed frog
XP_394282    7 RKLLERVKEQEELVRKLKAAKANDVQIAEEVTKLSELKAQLGNKN 51   honey bee
CAG31857     1 MADEAAVRQQAEVVRRLKQDKAEPDEIAKEVAKLLEMKAHLGGDE 45   chicken

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