Conserved Protein Domain Family
GlyRS_RNA
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cd00935: GlyRS_RNA 
GlyRS_RNA binding domain. This short RNA-binding domain is found at the N-terminus of GlyRS in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). This domain consists of a helix-turn-helix structure , which is similar to other RNA-binding proteins. It is involved in both protein-RNA interactions by binding tRNA and protein-protein interactions, which are important for the formation of aaRSs into multienzyme complexes.
Links
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Statistics
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PSSM-Id: 238472
Aligned: 9 rows
Threshold Bit Score: 82.9194
Created: 24-Sep-2002
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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tRNA binding
Feature 1:tRNA binding site [nucleic acid binding site]
Evidence:
  • Comment:based on similarity to EPRS RNA binding domain
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                  # #  #    #    #   #       #       #     
P41250        64 LAPLRLAVRQQGDLVRKLKEDKAPQVDVDKAVAELKARKRVLEAKELALQP 114 human
AAK92837      10 LAPLRERVQEQGNLVRDLKAKGAPEIDVKKAVAELKARKKLLEDKELALTP 60  fruit fly
Q10039        74 LAPLRAAVKEYGDLIRDLKAKGAPKIDIDKAVVELKARKRLLEDTEIALAP 124 Caenorhabditis elegans
NP_001026681  10 LAPLRQAVRHQGELVRKLKEEKAPQVDIDRAVAELKARKRVLEAKELALQP 60  chicken
AAH77232      72 LAPLRLAVKEQGDLVRKLKEEKVPQVDVDRAVAELKARKRTLEAKELSLQP 122 African clawed frog
AAH96883      89 LAPLRLAVKEQGDLVRQLKAENAPDVDVSKAVAELKARKRFLEAKELSLQP 139 zebrafish
XP_784166     15 LAPLRASVKEQGDLVRQMKEGGTPAHDIKRAVVELKARKKALEEKELALTS 65  purple urchin
XP_391940     71 LSPFRDSVKEQGDYVRKLKFDGASELDIKKAVVELKLRKKLLEEKELSFLE 121 honey bee
AAX25703      57 IESLRAKVRDQGNLVRRLKEEKASDGALKEAVTILKSYKKALDDKEIELSP 107 Schistosoma japonicum

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