1BCF,1JGC,1NF4,2FKZ,3BKN,3FVB


Conserved Protein Domain Family
Bacterioferritin

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cd00907: Bacterioferritin 
Click on image for an interactive view with Cn3D
Bacterioferritin, ferritin-like diiron-binding domain
Bacterioferritins, also known as cytochrome b1, are members of a broad superfamily of ferritin-like diiron-carboxylate proteins. Similar to ferritin in architecture, Bfr forms an oligomer of 24 subunits that assembles to form a hollow sphere with 432 symmetry. Up to 12 heme cofactor groups (iron protoporphyrin IX or coproporphyrin III) are bound between dimer pairs. The role of the heme is unknown, although it may be involved in mediating iron-core reduction and iron release. Each subunit is composed of a four-helix bundle which carries a diiron ferroxidase center; it is here that initial oxidation of ferrous iron by molecular oxygen occurs, facilitating the detoxification of iron, protection against dioxygen and radical products, and storage of ferric-hydroxyphosphate at the core. Some bacterioferritins are composed of two subunit types, one conferring heme-binding ability (alpha) and the other (beta) bestowing ferroxidase activity.
Statistics
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PSSM-Id: 153099
View PSSM: cd00907
Aligned: 73 rows
Threshold Bit Score: 150.389
Threshold Setting Gi: 148241925
Created: 24-Sep-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:ferroxidase diiron center [ion binding site]
Evidence:
  • Structure:1NF4; Desulfovibrio desulfuricans bacterioferritin: reduced diiron site
    View structure with Cn3D
  • Comment:Ferroxidase center where oxidation of ferrous iron by molecular oxygen takes place.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                        #      #                         #  #                           
1BCF_A         2 KGDTKVINYLNKLLGNELVAINQYFLHARMFKNWGLKRLNDVEYHESIDEMKHADRYIERILFLEGLPNLQdlGKLNIGe 81  Escherichia coli
1NF4_A         7 DRKAKVIEVLNKARAMELHAIHQYMNQHYSLDDMDYGELAANMKLIAIDEMRHAENFAERIKELGGEPTTQkeGKVVTGq 86  Desulfovibrio d...
NP_869858      1 MSKTQTIENLQKALAMELTATHQYQLHACVLDDWGMGLLASKMREELQEELGHSEDFLNRILFLKGNPNLTmqKTPVQAk 80  Pirellula sp.
ZP_00963552    1 MSNNKTVENLNKALQMEISASHQYQLHAHVLDDWGLDRLAAKMREEQAEEAGHSDLFIERILFLKGTPEIAfeKTPKRAe 80  Sulfitobacter s...
YP_001227082   7 QLHHRVLAALGQALSLELTAVQQYLTHAALLEAWGDPLTADRFRQETVEEMRHSERIIQRMVSLGLAPAASqlQPVATAt 86  Synechococcus s...
ZP_01871625    1 MNKQKSIELLNKAIAEELSAIHQYMYFHFILDDLGYDLLAGIFKKTAIDEMLHTEKFAERILFLGGEIEMKpaHEVEHIr 80  Caminibacter me...
ZP_01901084    2 TDRSTSIENLQTALAMELTAVNQYLLHAHTLEDWGLDKLAHRMRDEMHEELGHAGQFIERIMFLGGTPELKptKTPKMAt 81  Roseobacter sp....
ZP_02425620    8 NKYQKSIDLLNDALGKEIATSLQYMYFHVHFEDAGYEYLSKKMRMISIAEMRHSEELSDRILFLQGDVNMNpsFPTRQIt 87  Alistipes putre...
YP_001918242   8 QKKQKVIEVLNKARSMELQAIHQYMNQHYSLDDKDYGEFATKIRTIAIDEMRHAETFAERVKELDGEPTTElaGGVEKNq 87  Natranaerobius ...
ZP_03907688    3 KKFTKSIELLNKSVADEIAALHQYMYFHFHCDDQGYDLLAGLFRRIAIEEMMHVEKLAERILFLDGDVIMKaeSDVIPEk 82  Denitrovibrio a...
Feature 1                    #      #                         #  #                        
1BCF_A        82 DVEEMLRSDLALELDGAKNLREAIGYADSVHDYVSRDMMIEILRDEEGHIDWLETELDLIQKMGlqNYLQAQI 154 Escherichia coli
1NF4_A        87 AVPVIYESDADQEDATIEAYSQFLKVCKEQGDIVTARLFERIIEEEQAHLTYYENIGSHIKNLGd-TYLAKIA 158 Desulfovibrio desulfur...
NP_869858     81 SLKEMFESDLADEKEAIDFYTTASIQASEDRDIGTRQLFERIAVDEEGHAGWLELQLDLLERMGepAYIAKHM 153 Pirellula sp.
ZP_00963552   81 TLRDMFKADLADEEDAIAFYTRAAREAYEADDIGSRRLFETIVLDEEGHKAWLELQLDLIERIGeqAYSAKLI 153 Sulfitobacter sp. NAS-...
YP_001227082  87 DLRGLLEVNTLLEDQLVRHYAEAQRFCQLVGDAEQAAFFSELLGEETAHAQALAQWLRELNGPGv-NSIHSPD 158 Synechococcus sp. RCC307
ZP_01871625   81 DVNEMLKWAMKSEEEAMEMYNDFAIECANARDAGTKQIFEAVIADEERHFEGFEQEFENLKKFGd-RYLAQQA 152 Caminibacter mediatlan...
ZP_01901084   82 NLKEVFEADKAEEKGAIDFYSKAARDASDSNDIGTRTLFETIVLDEEGHWDWLDRQLGTLDRMGepAFMSIYM 154 Roseobacter sp. AzwK-3b
ZP_02425620   88 DPKEMFRFAMQLEQSTIDSYNDAARIAAEADDSVTHKMFQDLAVEEEEHLDYFRNELQNLLDYGdkEYLALQS 160 Alistipes putredinis D...
YP_001918242  88 DVEKIFPFDSEQEEEAIETYNEFAQICRENNDTISAKLFETIIEEEQQHQNYFDDIDDHIKNLGn-TYLARMV 159 Natranaerobius thermop...
ZP_03907688   83 DVKKMLDMAREMEDHASEMYNTFANECSKASDSVTKTLFESLVVDEERHYDNFDDELENMDRFGe-NYLTLQA 154 Denitrovibrio acetiphi...

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