1VLG,1IES,1MFR


Conserved Protein Domain Family
Ferritin

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cd00904: Ferritin 
Click on image for an interactive view with Cn3D
Ferritin iron storage proteins
Ferritins are the primary iron storage proteins of most living organisms and members of a broad superfamily of ferritin-like diiron-carboxylate proteins. The iron-free (apoferritin) ferritin molecule is a protein shell composed of 24 protein chains arranged in 432 symmetry. Iron storage involves the uptake of iron (II) at the protein shell, its oxidation by molecular oxygen at the dinuclear ferroxidase centers, and the movement of iron (III) into the cavity for deposition as ferrihydrite; the protein shell can hold up to 4500 iron atoms. In vertebrates, two types of chains (subunits) have been characterized, H or M (fast) and L (slow), which differ in rates of iron uptake and mineralization. Bacterial non-heme ferritins are composed only of H chains. Fe(II) oxidation in the H/M subunits take place initially at the ferroxidase center, a carboxylate-bridged diiron center, located within the subunit four-helix bundle. In a complementary role, negatively charged residues on the protein shell inner surface of the L subunits promote ferrihydrite nucleation. Most plant ferritins combine both oxidase and nucleation functions in one chain: they have four interior glutamate residues as well as seven ferroxidase center residues.
Statistics
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PSSM-Id: 153098
View PSSM: cd00904
Aligned: 3 rows
Threshold Bit Score: 229.07
Threshold Setting Gi: 52696195
Created: 24-Sep-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
ferroxidase
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:ferroxidase diiron center [ion binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                   #                                 ##  #                           
1VLG_A     17 SEKVRKALNDQLNREIYSSYLYLSMATYFDAe--GFKGFAHWMKKQAQEELTHAMKFYEYIYERGGrVELEAIEKPps-n 93  Thermotoga maritim...
1IES_A      9 STEVEAAVNRLVNLYLRASYTYLSLGFYFDRddvALEGVCHFFRELAEEKREGAERLLKMQNQRGGrALFQDLQKPsqde 88  Equus caballus
1MFR_D     10 HSDCEAAVNRMLNLELYASYTYSSMYAFFDRddvALHNVAEFFKEHSHEEREHAEKFMKYQNKRGGrVVLQDIKKPerde 89  bullfrog
Feature 1                   #                                #  ##                            
1VLG_A     94 WNGIKDAFEAALKHEEFVTQSIYNILELASeekDHATVSFLKw-FVDEQVEEEDQVREILDLLEKAngq--msVIFQLDR 170 Thermotoga maritim...
1IES_A     89 WGTTLDAMKAAIVLEKSLNQALLDLHALGSaqaDPHLCDFLEshFLDEEVKLIKKMGDHLTNIQRLvgsqaglGEYLFER 168 Equus caballus
1MFR_D     90 WGNTLEAMQAALQLEKTVNQALLDLHKLATdkvDPHLCDFLEseYLEEQVKDIKRIGDFITNLKRLglpengmGEYLFDK 169 bullfrog

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