2ICY,2OEF,2I5K


Conserved Protein Domain Family
UGPase_euk

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cd00897: UGPase_euk 
Click on image for an interactive view with Cn3D
Eukaryotic UGPase catalyses the synthesis of UDP-Glucose.
UGPase (UDP-Glucose Pyrophosphorylase) catalyzes the reversible production of UDP-Glucose and pyrophosphate (PPi) from Glucose-1-phosphate and UTP. UDP-glucose plays pivotal roles in galactose utilization, in glycogen synthesis, and in the synthesis of the carbohydrate moieties of glycolipids, glycoproteins, and proteoglycans. UGPase is found in both prokaryotes and eukaryotes. Interestingly, while the prokaryotic and eukaryotic forms of UGPase catalyze the same reaction, they share low sequence similarity. This family consists of mainly eukaryotic UTP-glucose-1-phosphate uridylyltransferases.
Statistics
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PSSM-Id: 132998
View PSSM: cd00897
Aligned: 23 rows
Threshold Bit Score: 415.106
Threshold Setting Gi: 134105141
Created: 28-Oct-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
substrateactive site
Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:substrate binding site
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             ####          #                                  #                      
2ICY_A     77 LDKLVVLKLNGGLGTTMGCTGPKSVIEVRDGLTFLDLIVIQIENLNNkygcKVPLVLMNSFNTHDDTHKIVEkytn---- 152 thale cress
2OEF_A     73 LQSTVVLKLNGGLGTGXGLCDAKTLLEVKDGKTFLDFTALQVQYLRQhcseHLRFXLXDSFNTSASTKSFLKarypwlyq 152 Leishmania major
P78811    107 LNKLAVLKLNGGLGTTMGCVGPKSIIEVRDGNSFLDLSVRQIEHLNRkynvNVPFVLMNSFNTDEATAKVIKkyea---- 182 fission yeast
XP_761731 113 LNKLAVLKLNGGLGTTMGCTGPKSVIEVREGMTFLDLSVRQIEHLNSshnvNVPFILMNSFNTDDDTARVIQkyan---- 188 Ustilago maydis 521
AAD34028  106 ASKLAVLKLNGGLGTTMGCTGPKSVIEVRSEKTFLDLSVQQIKEMNEryniKVPLVLMNSFNTHQETGKIIQkyky---- 181 Dictyostelium disc...
CAD26174  102 LRKLAILKLNGGLGTTMGCVGPKSAITIKDGKNFIDLVVKQIRYLNSkykiDVPLILMNSFNTEGMTDKIIFry------ 175 Encephalitozoon cu...
NP_508277  75 LNKLAVIKLNGGLGTTMGCSKAKSLVEVREGYTFMDLAVLEHQKMCEahnvDTPLYLMNSFYTDEDTKKYLAekg----- 149 nematode
YP_055199  69 LDKTVIIKLNGGLGTSMGLDRAKSLLEVRDGKSFLDIIATQVLSARKtfgaRLPLMFMNSFNTREDTLKALEkypel--a 146 Propionibacterium ...
2I5K_A     90 LSKLAVLKLNGGLGTSMGCVGPKSVIEVREGNTFLDLSVRQIEYLNRqydsDVPLLLMNSFNTDKDTEHLIKkysa---- 165 baker's yeast
EAA35217  120 LNKLAVLKLNGGLGTSMGCVGPKSVIEVRDGMSFLDMSVRQVEHLNRtygsNVPILLMNSFNTDDDTAAIIKkyeg---- 195 Neurospora crassa ...
Feature 1              #                           # ##                           #           
2ICY_A    153 snvDIHTFNQSKYPRVvadefvpwp-skgktdkegWYPPGHGDVFPALMNSGKLDTFLSQGKEYVFVANSDNLGAIVDLT 231 thale cress
2OEF_A    153 vfdSEVELXQNQVPKIlqdtlepaa--waenpayeWAPPGHGDIYTALYGSGKLQELVEQGYRYXFVSNGDNLGATIDKR 230 Leishmania major
P78811    183 hkiDILTFNQSRYPRVhketllpvp-htadsaideWYPPGHGDVFEALTNSGIIDTLIAQGKEYLFVSNIDNLGAVVDLN 261 fission yeast
XP_761731 189 hnvEILTFNQSRYPRVnkesllpcp-rsatdnknlWYPPGHGDLFDAMNNSGLLDRLISAGKEYLFVSNVDNLGADVDLN 267 Ustilago maydis 521
AAD34028  182 sdvKIHSFNQSRFPRIlkdnlmpvp-dklfgsdseWYPPGHGDVFFALQNSGLLETLINEGKEYLFISNVDNLGAVVDFN 260 Dictyostelium disc...
CAD26174  176 --dGIKKFSQSKFPRIssetllpv---spshgdkgMYPPGHGDLFYSMKNSGMLEELLEGGYEYLFVSNIDNLASTVDLK 250 Encephalitozoon cu...
NP_508277 150 -ysNVKTFVQSKCPRLdaetklpiedenedwgddaWCPPGHGNIFQSLQNSGVLDQLLADGREIIFVSNIDNTGANTDLQ 228 nematode
YP_055199 147 vdgLELDFLQDQEPKLdaetlapve--wpkdssleWCPPGHGDLYTALLGSGVLDHLLEAGYQYASVSNGDNLGAVPDGR 224 Propionibacterium ...
2I5K_A    166 nriRIRSFNQSRFPRVykdsllpvp-teydspldaWYPPGHGDLFESLHVSGELDALIAQGREILFVSNGDNLGATVDLK 244 baker's yeast
EAA35217  196 hnvDILTFNQSRYPRIykdsllpvp-ksfdsplhdWYPPGHGDVFESLYNSGILDKLIERGIEIIFLSNADNLGAVVDLR 274 Neurospora crassa ...
Feature 1                             ###                          #                     #    
2ICY_A    232 ILKHLIQNknEYCMEVTPKTLADVKGGTLISye--------------gkVQLLEIAQVPDEHVNEFKSIEKFKIFNTNNL 297 thale cress
2OEF_A    231 VLAYXEKEkiDFLXEVCRRTESDKKGGHLARqtvyvkgkdgqpdaekrvLLLRESAQCPKADXESFQDINKYSFFNTNNL 310 Leishmania major
P78811    262 ILNHMVETnaEYLMELTNKTKADVKGGTLIDyd--------------gnVRLLEIAQVPPQHVEEFKSIKKFKYFNTNNL 327 fission yeast
XP_761731 268 IYQHMIDTqaEFISEVTDKTKADVKGGTLIDye--------------gtIRLLEIAQVPSEHVEDFKSVKKFKIFNTNNL 333 Ustilago maydis 521
AAD34028  261 ILEAMDKNkvEYIMEVTNKTRADVKGGTLIQye--------------gkAKLLEIAQVPSSKVEEFKSIKKFKIFNTNNI 326 Dictyostelium disc...
CAD26174  251 LLEYFATNelGFLMEVTDKTRADVKGGTLIEyk--------------gaLRLLEIAQVPSNKKSEFTSFKKFTIFNTNNL 316 Encephalitozoon cu...
NP_508277 229 IVQLMLDKnvDYIMECTPKTQVDVKGGTLIDig--------------grMMHLEMPQVPAENLPDFCSTKVFKIFNTNNI 294 nematode
YP_055199 225 LAGWFAASgaPYAAELCRRTINDKKGGHLAIrks------------ddqLILRDTAQTAEEEMDYFTDEHRHPFFHTNNL 292 Propionibacterium ...
2I5K_A    245 ILNHMIETgaEYIMELTDKTRADVKGGTLISyd--------------gqVRLLEVAQVPKEHIDEFKNIRKFTNFNTNNL 310 baker's yeast
EAA35217  275 ILQHMVETdaEYIMELTNKTKADVKGGTIIDye--------------gsVRLLEIAQVPKEHVNEFKSIKKFKYFNTNNI 340 Neurospora crassa ...
Feature 1                                                                            #        
2ICY_A    298 WVNLKAIKKLVEada--lkmEIIPNPKEvdg-------vkvLQLETAAGAAIRFFDNAIGVNVPRSRFLPVKASSDLLLV 368 thale cress
2OEF_A    311 WIRLPVLLETXQehggtlplPVIRNEKTvdssns--aspkvYQLETAXGAAIAXFESASAIVVPRSRFAPVKTCADLLAL 388 Leishmania major
P78811    328 WFHLPSVKRVVNnhe--lsmEIIPNKKTikhkg---eniniIQLETAAGAAIRHFKNAHGVNVPRRRFLPVKTCSDLLLV 402 fission yeast
XP_761731 334 WLNLRAVKRVLEnee--ldlEIIVNNKAldsg------eavIQLETAVGAAIKHFRGAKGVNVPRSRFLPVKSCSDLLLI 405 Ustilago maydis 521
AAD34028  327 WVNLKAMDRILKqnll-ddmDIIINPKVadg-------kniIQLEIAAGAAIEFFNNARGVNVPRSRFLPVKSTSDLFIV 398 Dictyostelium disc...
CAD26174  317 WINLKEMKKKLEegf--fdlDIIENKKAldd-------etvIQLETAIGSAIKYFPNSCGVVVPRSRFLPVKTCSDLFLV 387 Encephalitozoon cu...
NP_508277 295 YVNLKAVKKLLPdi----ksEIIVNKKTirs-------revLQLEFSIGGCIKNFDNALCVHVERKRFRPVKNLGDLLSL 363 nematode
YP_055199 293 WFDLEALKKVLDerhgvmglQIIRNEKTvdpkds--sstpvIQIESAMGGAIEVFEGATCICVDRSRFLPVKTTNELLLL 370 Propionibacterium ...
2I5K_A    311 WINLKAVKRLIEssn--lemEIIPNQKTitrdg---heinvLQLETACGAAIRHFDGAHGVVVPRSRFLPVKTCSDLLLV 385 baker's yeast
EAA35217  341 WMNVQAVKRVVEnne--lelEIIPNEKTipgdkkgesdisiVQLETAVGAAIKHFKGAHGVNVPRRRFLPVKTCSDLMLV 418 Neurospora crassa ...
Feature 1            
2ICY_A    369 QSDLYTL 375 thale cress
2OEF_A    389 RSDAYVV 395 Leishmania major
P78811    403 KSDLYSI 409 fission yeast
XP_761731 406 TSDLYSL 412 Ustilago maydis 521
AAD34028  399 QSNLYSL 405 Dictyostelium discoideum
CAD26174  388 ESNLFVE 394 Encephalitozoon cuniculi GB-M1
NP_508277 364 RSTLCDL 370 nematode
YP_055199 371 RSDVYDL 377 Propionibacterium acnes KPA171202
2I5K_A    386 KSDLFRL 392 baker's yeast
EAA35217  419 KSDLYTV 425 Neurospora crassa OR74A

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