1QMH


Conserved Protein Domain Family
RNA_Cyclase_Class_II
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cd00874: RNA_Cyclase_Class_II 
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RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine residue is found in all members of this subfamily.
Links
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Statistics
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PSSM-Id: 238446
Aligned: 24 rows
Threshold Bit Score: 396.589
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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putative activeadenylation
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:putative active site [active site]
Evidence:
  • Structure:1QMH_B charged pocket believed to be the active site of RNA cyclase activity
  • Comment:The putative location of the active site of cyclase is supported by mutagenesis experiments
  • Structure:1QMH_B binding citrate, which is believed to mimic the binding of the RNA backbone
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             ##   #                  #  # #     ##                                   
1QMH_B      8 LDGAQGEGGGQILRSALSLSMITGQPFTITSIRAGRAKPGLLRQHLTAVKAATEICGATVEGAELGSQRLLFRPGTVR-- 85  Escherichia coli
NP_868842   9 INGSEGEGGGQIVRSSLALAAVTGQPIRLTNIRGGRKKPGLLRQHLAGVRAIQQVCSGEVSGDQLGSGELTLVPGQLS-- 86  Pirellula sp. 1
Q8Y2V6     13 LDGAQGEGGGQILRTALTLSMLTGTPFRIERIRAGRSKPGLMRQHLTAVQAAAEVSGATVEGAEAGSQALAFAPGPIH-- 90  Ralstonia solanace...
O15746     38 IDGSILEGGGQILRNSVALASLFNKAISIEKIRYNRDQPGLKNQHKAGIDLMSRLFKAHLTGCSVGSCKLYYQPTQKTiq 117 Dictyostelium disc...
O77264      9 IDGSYLEGGGQALRNALSLSCILGKPVRVVKIRASRPSPGLSHQHLHGLNLLRDITNADVVGNYLLSSTVEFTPRTIL-- 86  fruit fly
Q8YVS3      4 IDGSYGEGGGQVLRTSLSLAAITGEPIRIAGIRAGRRKPGLAAQHLTAVRAAARICHGELQGDALGSTMLEFIPGGGVk- 82  Nostoc sp. PCC 7120
Q9HVJ9      6 IELDGSEGGGQILRSALSLSMTSGQPLRIRNIRGRRSRPGLLRQHLTAVRAAAEICAAEVEGAELGSRELAFRPGAIR-- 83  Pseudomonas aerugi...
O00442      8 VDGSIMEGGGQILRVSTALSCLLGLPLRVQKIRAGRSTPGLRPQHLSGLEMIRDLCDGQLEGAEIGSTEITFTPEKIK-- 85  human
NP_955830   8 MDGSVMEGGGQILRVSAALSCIQGASIKINKIRAGRSTPGLRPQHLSGLELLRDMCNGNLEGATVGSSEITLTPGKIK-- 85  zebrafish
Q9HRE8      2 HVLDGSSGGGQLVRTALTCAAVSGESFRMRYVRRARSNPGLQAQHCAAVNAVADICDAATDGVEVGSEAFSFEPEVAAee 81  Halobacterium sp. ...

Feature 1                                #                                                    
1QMH_B     86 -GGDYRFAIGSAG--------SCTLVLQTVLPALWFadGPSRVEVSGGTDNPSAPPADFIRRVLEPLLAKIGIHQQTTLL 156 Escherichia coli
NP_868842  87 -GGDHHFEVGSAG--------SAVLVAQTILPVLLHadAPSTITIGGGTHASWAPPFDFFLRCYLPLLAGMNAKVEAEIE 157 Pirellula sp. 1
Q8Y2V6     91 -GGDYRFAIGTAG--------SCTLVLQTVLPALWFadAPSTVAVSGGTHNRAAPPVDFLIRAWQPLLARMGVTQTLALK 161 Ralstonia solanace...
O15746    118 dDGVIEADTKTAG--------SICLMIQVSLPCLIFapHSTKMVLGGGTNCDFAPAADYIQNVFLPIATTMGFKCEMSID 189 Dictyostelium disc...
O77264     87 -DNTYRVETHTAA--------SITLIYQMALPVLLFagRPSRLIVSGGTNVDFAPPVEYMQEVLLPNLKHFGVSFDLKVQ 157 fruit fly
Q8YVS3     83 -AGNYIFDVSEVQqgg--sagAITLVLQTILLPLALadGDSHITLRGGTHVIFSPTVTYIERVYLPMLCRMGIKAQVKLG 159 Nostoc sp. PCC 7120
Q9HVJ9     84 -AGDYAFAIGSAG--------SCSLVLQTLLPALLAanGESRVRISGGTHNPLAPPADFLRDSWLPLLQRMGAEVDLELL 154 Pseudomonas aerugi...
O00442     86 -GGIHTADTKTAG--------SVCLLMQVSMPCVLFaaSPSELHLKGGTNAEMAPQIDYTVMVFKPIVEKFGFIFNCDIK 156 human
NP_955830  86 -GGNHIADTHTAG--------SVTLLMQVSLPCALFaqGPSELCLKGGTNAEMAPQIDYTVKVFKPIVERFGVQFDCDLR 156 zebrafish
Q9HRE8     82 aDDDEEPTLGGTTsvevgtagSIPLVFDSLLPLAGAldEPITATLTGGTDAKWAPPMDYFQHVKLPLLREHGIDATVSVD 161 Halobacterium sp. ...

Feature 1                                                                                     
1QMH_B    157 RHGFYPAGGGVVATEVSPVASFNTLQLgerg-nivqMRGEVLLagv--prHVAEREIATLAGSFSL---HEQNIHNLPRD 230 Escherichia coli
NP_868842 158 SHGFYPAGGGRIVMKVEPSTGITGLALtdra-gslqPKVTALVs------RIPETVGQRECDVIARktgWGQKAFQVVDV 230 Pirellula sp. 1
Q8Y2V6    162 RHGFYPAGGGEVLATVTPCAGRLGALHltergalreLSGQGIVanv--rpGVARRELEALAARVPGv--VGSVRELSPAE 237 Ralstonia solanace...
O15746    190 KRGFYPKGGGAVTLTTQPLTQPLSPITivnkgevnrIVIKSYFtsprispLVAERMNNTAKKLIKKd-fKKVDVETELID 268 Dictyostelium disc...
O77264    158 RYGFYPRGQGRCQLDVQPVTKLNSGKLvafg-riksVSGVAYCagr-lpvNIAIDMQQTAQREIHRl-wPSQQCSIEPIK 234 fruit fly
Q8YVS3    160 AWGWYPRGGGEVNLQVKGGCQLCGLNLlerg-elkrVQGLAVAtel--paHIPQRMANRAENLLRTa-gLRVSMQALREK 235 Nostoc sp. PCC 7120
Q9HVJ9    155 RHGFVPAGGGELLARVRPARWRPLQLEhpga--alrRQARALLagi--pgHVGERELERVRQRLGWs-dEERQLEFLAED 229 Pseudomonas aerugi...
O00442    157 TRGYYPKGGGEVIVRMSPVKQLNPINLterg-cvtkIYGRAFVagv-lpfKVAKDMAAAAVRCIRKe-iRDLYVNIQPVQ 233 human
NP_955830 157 MRGYYPKGGGEVVLKVNPAKELSPINMterg-nitkIYGRAFVagv-lpfKLAKDMSTAAIRTIRKe-iKDLYINIQSLQ 233 zebrafish
Q9HRE8    162 RRGFYPRGGGEATLTVEPSTPTPITLTergd--reaLTAYSVAe-----sSLADDEVAEQQATAAA---PDAAHEIAYTD 231 Halobacterium sp. ...

Feature 1                                                                    #                
1QMH_B    231 q------GPGNTVSLEVEsen-itERFFVVGEKRVSAEVVAAQLVKEVKRYLASTAAVGEYLADQLVLPMALAg----AG 299 Escherichia coli
NP_868842 231 qq---sgGPGNVVMIELGfdn-isELIIGFGKVGVKAEQVARAALREARAYLASDVPVGVYLADQLLLPMGLAarnghRS 306 Pirellula sp. 1
Q8Y2V6    238 -------GPGNALVLDAVheh-vtEVFTGFGERGVPAEQVAHGVASAALRYLHSTAAVDEYLADQLVLPMALAg----AG 305 Ralstonia solanace...
O15746    269 vsk-fsfGDGTFIEIRAYtdqgciFGATGNGAIGVPAEKVAEDAANSLLKDLQDGGCMDEYLQDQLIIFMALAk---gKS 344 Dictyostelium disc...
O77264    235 hsrqkafHNGAGILMTVNttsdvvLGASALGKKRIDGHVLGSEASCQLGDYMRKQVCVDDYMQDQLIIYMALAv---gRS 311 fruit fly
Q8YVS3    236 g-----vAPGAGIFLTAEycn-slTGFGGFGRLRLSSEKVAEIACGQLLQFHETGAPVDEHLADQLLLPAVLAs---eSS 306 Nostoc sp. PCC 7120
Q9HVJ9    230 q------GPGNALLLRIDceh-icATFCAFGQAGVSAERVAEQVATQAIGWMESGCAADEHLADQLLLPMALAg----AG 298 Pseudomonas aerugi...
O00442    234 epkdqafGNGNGIIIIAEtstgclFAGSSLGKRGVNADKVGIEAAEMLLANLRHGGTVDEYLQDQLIVFMALAn---gVS 310 human
NP_955830 234 ekd-kacGNGNGIIIIAEsstgciFAGSSLGKKGVYADKVGIEAAEMLLRNIRHNGCVDEFLQDQLIIFMALAn---gTS 309 zebrafish
Q9HRE8    232 a-----dSAGSAVVLAAEyeh-srAGFAALGERGVSADAVGENAADALAAFESGPGAVDSHLADQLVPVVAVA-----GG 300 Halobacterium sp. ...

Feature 1              #                                      
1QMH_B    300 EFTVAHPSCHLLTNIAVV----------ERFLPV--------RFSLIE 329 Escherichia coli
NP_868842 307 EFRTGPLSLHSQTHIDVL----------RNFLEVn-------IQCVSN 337 Pirellula sp. 1
Q8Y2V6    306 CFTAVTASPHLTTNIAVIekf-----lpVHITVQaer--dasVVRVQV 346 Ralstonia solanacearum
O15746    345 QIKTGPISLHTQTSIHIT----------SLMTGA--------IFTITP 374 Dictyostelium discoideum
O77264    312 TMRTGKLTNHTRTAINVA----------EQMTGV--------KFDVAM 341 fruit fly
Q8YVS3    307 QYKVAEVSTHLTTNAAVIe---------KFGLGKitvnqaerVVAIAS 345 Nostoc sp. PCC 7120
Q9HVJ9    299 SFTTPRLSAHLQSNRRVIerflpvrigdQALDGGg------hRIVITS 340 Pseudomonas aeruginosa
O00442    311 RIKTGPVTLHTQTAIHFAeqi-----akAKFIVK--------KSEDEE 345 human
NP_955830 310 RMRTGPITLHTQTAIHVA----------EQLTNA--------KFAISK 339 zebrafish
Q9HRE8    301 EVRAPEVTTHIETCVDLLaefdy-didiEHTDDG--------AVVLSA 339 Halobacterium sp. NRC-1

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