Conserved Protein Domain Family
PI3Ka_II
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cd00869: PI3Ka_II 
Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases phosphorylate phosphoinositol (PtdIns), PtdIns(4)-phosphate, but not PtdIns(4,5)-bisphosphate. They are larger, having a C2 domain at the C-terminus.
Links
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Statistics
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PSSM-Id: 238441
Aligned: 5 rows
Threshold Bit Score: 260.852
Created: 4-Feb-2003
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
O00750     813 EEDQRKLKDIMQKEsLYWLTDADKKRLWEKRYYCHSEVSSLPLVLASAPSWEWACLPDIYVLLKQWTHMNHQDALGLLHA 892  human
T13801    1038 LDANLQEELLDTAElGYTGATERREVFWEKRLYLQSYPNALPKVLHAAHSWDYANLIDLHALLHSWAPLSPLQSLELLLP 1117 fruit fly
O75747     651 KECIKHIARLSQKQtPLLLSEEKKRYLWFYRFYCNNENCSLPLVLGSAPGWDERTVSEMHTILRRWTFSQPLEALGLLTS 730  human
T42642     841 SDIKGKLLDIIHRDsSFGLSKEDKVFLWENRYYCLKHPNCLPKILASAPNWKWANLAKTYSLLHQWPPLCPLAALELLDA 920  house mouse
NP_510529  784 IETQEYLLELIENQdTSTLETDDQDLIWQKRLHLTNQPEALPLVLSSLQDWSFGFVMRVYQILEEWAPLRPEIAMEFLLP 863  Caenorhabditis e...

O00750     893 TFPDQEVRRMAVQWIGSLSDAELLDYLPQLVQALKYEcyldSPLVRFLLKRAVSDLRVTHYFFWLLKDGLKDsqf-sirY 971  human
T13801    1118 RYPDAKVREKAVEWISKMPNDQLVDFLPQLVQSLKHDtyegSAMARFLLSKCLESPRFAHHMYWLLVHSLPDd-----pH 1192 fruit fly
O75747     731 SFPDQEIRKVAVQQLDNLLNDELLEYLPQLVQAVKFEwnleSPLVQLLLHRSLQSIQVAHRLYWLLKNAENEayf-kswY 809  human
T42642     921 KFADQGVRSLAVSWMEAISDDELADLLPQFVQALKYEiylnSSLVRFLLSRALGNIQIAHSLYWLLKDALHDthfgsryE 1000 house mouse
NP_510529  864 KYPDERIRAHAVQSLARGSTDFLYHTIPQFIEALRFElyekSALADFILELSFVSLDFTFEIYWQLQQRVDHc-----aV 938  Caenorhabditis e...

O00750     972 QYLLAALLCC 981  human
T13801    1193 NSIGAAMVDQ 1202 fruit fly
O75747     810 QKLLAALQFC 819  human
T42642    1001 HVLGALLSVG 1010 house mouse
NP_510529  939 DDLPYAIRCQ 948  Caenorhabditis elegans
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