1KN3,1B7A,1BEH,1WPX,2IQX,1QOU,1WKP,2R77


Conserved Protein Domain Family
PEBP_euk

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cd00866: PEBP_euk 
Click on image for an interactive view with Cn3D
PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes
PhosphatidylEthanolamine-Binding Proteins (PEBPs) are represented in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). The members in this subgroup are present in eukaryotes. Members here include those in plants such as Arabidopsis thaliana FLOWERING LOCUS (FT) and TERMINAL FLOWER1 (FT1) which function as a promoter and a repressor of the floral transitions, respectively as well as the mammalian Raf kinase inhibitory protein (RKIP) which inhibits MAP kinase (Raf-MEK-ERK), G protein-coupled receptor (GPCR) kinase and NFkappaB signaling cascades. Although their overall structures are similar, the members of the PEBP family have very different substrates and oligomerization states (monomer/dimer/tetramer).
Statistics
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PSSM-Id: 176644
View PSSM: cd00866
Aligned: 194 rows
Threshold Bit Score: 80.11
Threshold Setting Gi: 189207549
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
substrate
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:substrate binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                             #             # #          
1KN3_A        19 HLLRVTYte------aEVEelGQVLtptqvKHRPgSISWDGldpgKLYTLILTDPDAPsrkkpvyREWHHFLVVNMKgnd 92  house mouse
1BEH_A        23 HPLHVTYag------aAVDelGKVLtptqvKNRPtSISWDGldsgKLYTLVLTDPDAPsrkdpkyREWHHFLVVNMKgnd 96  human
NP_502042     24 QKLHLCWd-------gIQVepGMTMqvrnlKNAP-RWALPGadpeSIYTVLMIDPDNLsrknpsvAEWLHWLVCNIPasn 95  nematode
XP_001625919  44 VNLDIRYes-----gaKVHh-GNFLtpsqaLLEP-DVQYTSde-dTMWSLLLTTPDGNiwe--kdTELLHWLVVNIQgsr 113 starlet sea ane...
XP_001640505  79 KRLRVSFg-------gSEVncGEVKnyesvTETP-EISFPNaqesKLYTVMVIDPDAPspirhqyRSWLHYLKVNIPsde 150 starlet sea ane...
XP_001604304 136 VPLTIDYdfgsedklaRVHr-GNLIksyeaKNAP-SVTYKAep-dSLYTLLLTTPDGNfsd--psYEYCHWFIGNIPgnd 210 jewel wasp
XP_001746551 144 KNFAVSWad------tYTYr-GNLVapndtLVAP-AFHFEPea-nVQYTVALLDADGRldg--seGQVAHALTCNLTgp- 211 Monosiga brevic...
XP_002111463 118 VNFGVEYpn------yRVQw-GNLIspsktAARP-KISFAPkyndGLWTLIMINPDGVfienqqeSEILHWLLINMApst 189 Trichoplax adha...
XP_002125755 215 LRMEVGYkdgg-sfinPVHy-GNEIspseaSTQP-EVTYQSea-dGLWSLLLLNLDGNied--ndKEYLHWFVTNIEgdd 288 Ciona intestinalis
XP_002404277 143 MYLNVYYehda-ehvmPVYh-GNHIlpseaSQAP-SVSFDSep-dALWSLVLTSLDGHlld--ndKEYLHWFVVKYIpga 216 black-legged tick
Feature 1                                   ####     # #                                         
1KN3_A        93 ---------------isSGNVLSDYVGSGPPkgtGLHRYVWLVYQQdkplrcdepilt---nrsgdhrgkfkTAAFRKKY 154 house mouse
1BEH_A        97 ---------------isSGTVLSDYVGSGPPkgtGLHRYVWLVYEQdrplkcdepils---nrsgdhrgkfkVASFRKKY 158 human
NP_502042     96 ii-----------dginGGQHQMAYGSPAPGprtDLHRYVILMWEHagrrisvpk---------pssrakfnVKQFIEKN 155 nematode
XP_001625919 114 ---------------vsNGTVLCEYLPPIPPqgtGFHRYTFCLLRQeqqlkpytlpt-----frsltdrsisTSALISKV 173 starlet sea ane...
XP_001640505 151 laqrldiqsgmdtiqsgMDTELKSYRPPSPPsgsGLHRYKYYALEQtgkvrpsp----------iserrsfdAQEFAAKH 220 starlet sea ane...
XP_001604304 211 ---------------vaKGEQLVDYLRPIPPkgiGFCRYIFVLYKQdkkidfseykke--ipclkltdrdwkTYDFIRKH 273 jewel wasp
XP_001746551 212 ---------------taSGDEVLPYMPLTPFqgsGYHRVVAVLLQQsgaldaaalrdslpavssqnplsnryMKLQDWAR 276 Monosiga brevic...
XP_002111463 190 ---------------aiKGVEACKYLQPLPIrgtGYHRLIFLLCKQsreipvpdqi-------tdiadrsfsTYNFLIQH 247 Trichoplax adha...
XP_002125755 289 ---------------itTGETIIDYLQPLPPrgtGYHRMVFLLFKQtnklniqpheh-----pcplqdrsfrTRDFYRQH 348 Ciona intestinalis
XP_002404277 217 c-------------nvaNGEVVCDYMQPFLPrgtGYHRYVFVLYKQeglidyskfklp--pkctsleqrtfkTHNFYEEH 281 black-legged tick
Feature 1                      
1KN3_A       155 HLGap-vAGTCYQA 167 house mouse
1BEH_A       159 ELRap-vAGTCYQA 171 human
NP_502042    156 KLGdp-iAGNFFLA 168 nematode
XP_001625919 174 QDRltpvGLGFFQA 187 starlet sea anemone
XP_001640505 221 NLVv--kAYNEFKT 232 starlet sea anemone
XP_001604304 274 QDYmtpaGLAFFQC 287 jewel wasp
XP_001746551 277 QHNlqpvAFSFSQA 290 Monosiga brevicollis MX1
XP_002111463 248 QDSlkpvGLRFFQS 261 Trichoplax adhaerens
XP_002125755 349 EETiipmSLRFYQS 362 Ciona intestinalis
XP_002404277 282 EKVltpaGLAFFQC 295 black-legged tick

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