1H4S


Conserved Protein Domain Family
ProRS_anticodon_zinc
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cd00862: ProRS_anticodon_zinc 
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ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is transferred to a ribose 3' OH group of the appropriate tRNA only, and an additional C-terminal zinc-binding domain specific to this subfamily of aaRSs.
Links
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Statistics
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PSSM-Id: 238439
Aligned: 22 rows
Threshold Bit Score: 198.29
Created: 24-Sep-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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anticodonzinc-binding
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:anticodon binding site
Evidence:
  • Structure:1H4S_B; T. thermophilus proRS bound to tRNA anticodon stem using 3.5A
  • Citation:PMID 9493271
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                      ##                                          #     #       #    
1H4S_B    278 GLVLPPRLAPIQVVIVPIYkd--eSRERVLEAAQGLRQALLAqGLRVHLDDRDqhTPGYKFHEWELKGVPFRVELGPKDL 355 Thermus thermophilus
6459012   293 GLMMPPRIAPIQVVVIPVGrk--dNFDQMVQEGEKLAAELRAqGLRVKVDGRDgvTNGFKYNDWELKGVPVRIELGPRDL 370 Deinococcus radiod...
3257420   277 GMVLPPTIAPIQVVIVPIPkk--gSEEEVYSYAKGIEEELRDaGIRVYLDLRDk-RPGWKFYDWELKGVPVRVEVGPIDV 353 Pyrococcus horikos...
3334356   285 GLCLPPDVAAHQVVIVPIIfk--kAAEEVMEACRELRSRLEAaGFRVHLDDRDi-RAGRKYYEWEMRGVPLRVEIGPRDL 361 Methanothermobacte...
NP_279476 247 GLVLPPTVAPKQVVIVPIWqe--dTKDDVEQYGAEIAAELEAqGVRVHFDDRDgrNPGFKFNEWELNGVPVRFEIGPNEV 324 Halobacterium sp. ...
5106029   281 GLVIPPSVAPIQVVVIPITpgdeeKRGKVLTYTAKAAEALEKaGLRVHVDDREweRPGAKFYYWEAKGVPIRVEIGLREA 360 Aeropyrum pernix K1
NP_111600 273 GLILPPAIAPIQVVIVPIP-----GEGVERYAKDIETTLNGI-GIRCHVDNRDnyTPGYKYNDWEMRGVPLRIEVGEREL 346 Thermoplasma volca...
BAB66508  279 GPVLNPVIAPIKVVIVPIPakdeeTTAKIINYAKEVGENLKNrGITVVIDDDKekTPGEKFYIWELKGVPLRIEIGPKEL 358 Sulfolobus tokodai...
NP_394395 273 GLVLPPDVAPIQVIIIPIP-----GAGVMEYARDVENTLNSI-NIRVKVDDREnyTPGYKFNDWEMRGVPLRIEIGEREV 346 Thermoplasma acido...
6015904   279 GPVLPPSVAPIKVVVIPIPakneeETQQVMKYSIEICEMFNKnNITCLTDQDTekTPGEKFYIWEIKGVPIRLEIGPREL 358 Sulfolobus solfata...

Feature 1          # #                                                                        
1H4S_B    356 EGGQAVLASRL-GGKETLPLAALPEALPGKLDAFHEELYRRALAFREdhTRKVd--tYEAFKEAVq-----eGFALAFHC 427 Thermus thermophilus
6459012   371 ESGVLVVKNRHsEDKETLPRAEAVSGMSARLDTIHDFLMKRATDFLLanTAEVd--sYDAFQREIea----gHWVRAYHC 444 Deinococcus radiod...
3257420   354 QNSTVVLARRDkLEKITVKREELVDKVRELFEDIMEFLYERANEWLEshIKRVd--tLEEAKAVFed---rrGIVEIPWC 428 Pyrococcus horikos...
3334356   362 EKGAAVISRRDtGEKVTADLQGIEETLRELMKDILENLRTRAWERMEseIREAe--tLEEASRIVde---krGIISFMWC 436 Methanothermobacte...
NP_279476 325 EDDEVTVVHRPdGESTVEDRAAIADRVHDHLDEVYDKLYDAAADRLAenVREAdn-rADILGTIGqh----gGYVKAPWC 399 Halobacterium sp. ...
5106029   361 EQDTLTIARRDtLEKTEVPLGEAGNRIRELMAQIESSMRERAKSFFG--ERLLr---TESLEEARdwvegrrGIAEIPWC 435 Aeropyrum pernix K1
NP_111600 347 KEKTVTLAARNiRGKKTVQREKLVYEVPDMLDLVKEKITEDAKKTFN--SLVVs---ASSLDDFKk-----eGLIKAFWC 416 Thermoplasma volca...
BAB66508  359 NNNTVYIKRRDtFEGKSVPKDKAVEEVNTLLEKIKNDLHEKALKFLK--ERIIy---TEDLNEAKkileeraGVVEVPWC 433 Sulfolobus tokodai...
NP_394395 347 KNRTLTISMRNiQGKLTIERSKLIYEVPDTLIRIREKMMENAQKVFK--DHVF----RATKLEEFnr----dGLITAFWC 416 Thermoplasma acido...
6015904   359 ISGTVFIKRRDnFKSYTVRKEEAINKIKELLNEIQEDLRRKAWEDLK--SRIEysndIEKAKKILgn---nsGIVEVPWC 433 Sulfolobus solfata...

Feature 1                                                                         
1H4S_B    428 GdkACERLIQEETt--ATTRCVPfeae------------------peeGFCVrCGrpsaYGKRVVFAK 475 Thermus thermophilus
6459012   445 GepACEKSIKEDTk--ATARNVPfddaef-------------faergeGQCVkCGqpsaYGKRVLFGR 497 Deinococcus radiodurans R1
3257420   429 GeeSCGLKMEEELe--AKMLGIPypeeka--------------kapegSKCPvCGreakFIARFARTY 480 Pyrococcus horikoshii OT3
3334356   437 GeeECGMDVEEKVr--VDILGIQee---------------------gsGTCInCG----REAPTGLTL 477 Methanothermobacter thermautot...
NP_279476 400 GdqDCEAEIKDQIa--AEIVMVPlgedsaaraaselegervpepdhdgEDCAiCGdeatRTAYFAKSY 465 Halobacterium sp. NRC-1
5106029   436 GreSCGLEMEERVn--GKVLGTPwpeep----------------veegKRCPlCGrpavAWIRLAKTY 485 Aeropyrum pernix K1
NP_111600 417 GskECSDKIENETeksALGFNLNnd---------------------etGKCIvCGk---AGKLAIFSR 460 Thermoplasma volcanium GSS1
BAB66508  434 GdnNCGLQLQDVTn--ARVLGIPldedk----------------dvsnAKCVmCKkpakSLLRLAKTY 483 Sulfolobus tokodaii str. 7
NP_394395 417 GskECSDKIEAETeksVLGFMVDss---------------------etGKCVvCGk---NGKMAVFSR 460 Thermoplasma acidophilum DSM 1728
6015904   434 GsnECGLKIEELTn--ARVLGYPiekr------------------evnDKCViCKmnakTVLRIAKTY 481 Sulfolobus solfataricus

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