Conserved Protein Domain Family
ProRS_anticodon_short
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cd00861: ProRS_anticodon_short 
ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is transferred to a ribose 3' OH group of the appropriate tRNA only.
Links
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Statistics
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PSSM-Id: 238438
Aligned: 35 rows
Threshold Bit Score: 82.6374
Created: 24-Sep-2002
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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anticodon
Feature 1:anticodon binding site
Evidence:
  • Comment:based upon similarity with ProRS anticodon binding domain interaction with tRNA anticodon stem
  • Citation:PMID 9493271
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                       ##                                             #     #       #          
11134893            470 PYDLHILALNmk-ndGQRELAEKLYADLKAe------gYEVLYDDRAe-rAGVKFADSDLIGLPIRITVGKRAd------ 535 Bacillus...
REFGENOMES:NCgl1919 489 PYQVHVVAANkd--aAAIEAAERFAAELSAa------gLDVLFDDRPkvsPGVKFKDAELLGMPFALILGRGYa------ 554 Coryneba...
13633970            473 PFSITIAFNGgd--tVSQELAETIYHELQSq------gYEPLLDDRDe-rLGFKLKDSDLIGIPYKLILGKSYq-----s 538 Chlamydo...
2501040             485 PFDVHLVIANkd--aQARAGATALAADLDRl------gVEVLLDDRQa-sPGVKFKDAELLGMPWIVVVGRGWa------ 549 Mycobact...
NP_281727           473 PFVLEIIVSNlk-deKALEFANKLYRDLTNl------gLEVLLDDRNe-rFGVKMNDFELMGFPYALVIGKGLe------ 538 Campylob...
3687477             328 PWKVLVVPTSd----NHIQSAETVYDATANvv----gfDNVLLEDRQnraFGYKMRDAELIGYPFVIVVGSRFq-----e 394 fission ...
2501038             478 PFDVVIVVSNwk-deAQKKLAFEVYERLLQk------gVDALLDDRDa-rFGAKMRDFELIGERLALIIGKQTl-----e 544 Helicoba...
6686306             473 PFSITILYNGgd--tEGEATALQLYQSLNTe------gFEPLLDDRNe-rLGFKLKDSDLLGIPYKLIIGKSFq-----s 538 Chlamydi...
7292265             328 PYDVCLIGPKqg--sKEQPEAEVIENELLLnvgeicghQELLHDDRKeltIGKRLLEAKRLGHPLTIVVGAKSar---ld 402 fruit fly
CAB04884            322 PFDAVIIVKKslmsnVIVEMASSSASRYLK--------GGILLDDRVemsAGKRIHDANRLGIPFILVIANETerslatq 393 Caenorha...

Feature 1                   # #                          
11134893            536 EGIVEVKIRQt-GESTEISV-----DELSAFIS 562 Bacillus subtilis
REFGENOMES:NCgl1919 555 EGKVELRVRG--GEKSELDA-----DQAVAQIV 580 Corynebacterium glutamicum ATCC 13032
13633970            539 SGIFEIESRS--GEKYTVSP-----EAFPTWCQ 564 Chlamydophila pneumoniae
2501040             550 DGVVELRDRFsgQTRELVAGas-laTDIAAAVT 581 Mycobacterium tuberculosis
NP_281727           539 NNEIELIQREg-LVKELIKT-----DELMEILK 565 Campylobacter jejuni subsp. jejuni NCTC 11168
3687477             395 EGICEIIVRSs-GERYKLDK-----DSLHQVLL 421 fission yeast
2501038             545 SKEFECIKRAn-LEKQTIKD-----IELEEKIL 571 Helicobacter pylori
6686306             539 TGLLEIESRS--GEKCNVSP-----ENLLDWCS 564 Chlamydia trachomatis
7292265             403 SPKLEVHTSK--GETYELDF-----SETLKLVA 428 fruit fly
CAB04884            394 KPVIEVFTTHa-KSAEPMSQgsmslDRFVTFVQ 425 Caenorhabditis elegans

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